loading...| Preferred Name |
trandolapril |
|
| Synonyms |
Mavik |
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| Definitions |
A non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, trandolapril is converted by de-esterification in the liver into its active form trandolaprilat. Trandolaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Trandolaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. [url:http://purl.obolibrary.org/obo/NCIT_C61978] |
|
| ID |
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02627 |
|
| definition |
A non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, trandolapril is converted by de-esterification in the liver into its active form trandolaprilat. Trandolaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Trandolaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. [url:http://purl.obolibrary.org/obo/NCIT_C61978] |
|
| label |
trandolapril |
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| MIO_ID |
MIO:02627 |
|
| prefLabel |
trandolapril |
|
| reference |
NCIT:C61978 |
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| synonyms |
Mavik |
|
| subClassOf |
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02115 |