loading...| Preferred Name |
cilazapril monohydrate |
|
| Synonyms |
(1S,9S)-9-(((S)-1-Carboxy-3-phenylpropyl)amino)octahydro-10-oxo-6H-pyridazino(1,2-a)(1,2)diazepine-1-carboxylic acid 9-ethyl ester monohydrate Ro 31-2848 monohydrate cilazapril |
|
| Definitions |
A pyridazine angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, cilazapril is rapidly metabolized in the liver to cilazaprilat; cilazaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II, resulting in vasodilation. Cilazaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. [url:http://purl.obolibrary.org/obo/NCIT_C76133] |
|
| ID |
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02620 |
|
| definition |
A pyridazine angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, cilazapril is rapidly metabolized in the liver to cilazaprilat; cilazaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II, resulting in vasodilation. Cilazaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. [url:http://purl.obolibrary.org/obo/NCIT_C76133] |
|
| label |
cilazapril monohydrate |
|
| MIO_ID |
MIO:02620 |
|
| prefLabel |
cilazapril monohydrate |
|
| reference |
UMLS:C0055723 NCIT:C76133 |
|
| synonyms |
(1S,9S)-9-(((S)-1-Carboxy-3-phenylpropyl)amino)octahydro-10-oxo-6H-pyridazino(1,2-a)(1,2)diazepine-1-carboxylic acid 9-ethyl ester monohydrate Ro 31-2848 monohydrate cilazapril |
|
| subClassOf |
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02115 |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C76133 | NCIT | LOOM | |
| http://purl.bioontology.org/ontology/SNOMEDCT/725786001 | SNOMEDCT | LOOM | |
| http://purl.obolibrary.org/obo/NCIT_C76133 | BERO | LOOM | |
| http://purl.obolibrary.org/obo/CHEBI_145568 | CHEBI | LOOM | |
| http://purl.obolibrary.org/obo/CHEBI_145568 | BERO | LOOM |