Preferred Name |
interleukin-12 |
|
Synonyms |
interleukin 12 interleukin-12 natural killer cell stimulatory factor cytotoxic lymphocyte maturation factor clmf il-12 il-12 p70 il-12p70 il12 nksf |
|
Definitions |
Exhibiting a broad range of biological activities on T and natural killer cells, Interleukin-12 is a disulfide-bonded heterodimeric cytokine composed of a 35-kD IL12A subunit (IL-6 Superfamily) and a 40-kDa IL12B subunit (Type I Cytokine Receptor 3 Family). IL12 stimulates T-cell-independent production of IFN-gamma by PBMCs, enhances NK cell lytic activity, acts as a growth factor for T- and NK-cells, and is important for Th1 and Th2 cell differentiation. Lymphocyte responses to IL12 require NOS2A and are mediated by STAT4 activator of transcription. (NCI) [url:http://purl.obolibrary.org/obo/NCIT_C20514] |
|
ID |
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02472 |
|
definition |
Exhibiting a broad range of biological activities on T and natural killer cells, Interleukin-12 is a disulfide-bonded heterodimeric cytokine composed of a 35-kD IL12A subunit (IL-6 Superfamily) and a 40-kDa IL12B subunit (Type I Cytokine Receptor 3 Family). IL12 stimulates T-cell-independent production of IFN-gamma by PBMCs, enhances NK cell lytic activity, acts as a growth factor for T- and NK-cells, and is important for Th1 and Th2 cell differentiation. Lymphocyte responses to IL12 require NOS2A and are mediated by STAT4 activator of transcription. (NCI) [url:http://purl.obolibrary.org/obo/NCIT_C20514] |
|
label |
interleukin-12 |
|
MIO_ID |
MIO:02472 |
|
prefLabel |
interleukin-12 |
|
reference |
NCIT:C20514 |
|
synonyms |
interleukin 12 interleukin-12 natural killer cell stimulatory factor cytotoxic lymphocyte maturation factor clmf il-12 il-12 p70 il-12p70 il12 nksf |
|
subClassOf |
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:01462 |