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Last uploaded: January 31, 2024

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Preferred Name	Sirolimus
Synonyms	Rapamune AY 22 989
Definitions	A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.
ID	http://purl.bioontology.org/ontology/MESH/D020123
altLabel	Rapamune I 2190A AY 22-989 AY 22989 Rapamycin I2190A I-2190A AY 22 989
AQL	AA AD AE AG AI AN BL CF CH CL CS EC HI IM IP ME PD PK PO RE SD ST TO TU UR
cui	C2350768 C0813828 C0072980 C0878382
DC	1
definition	A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.
DX	19990101
HN	99; use SIROLIMUS (NM) 1980-97
Inverse of AQ	http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000031 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000819 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000528
Inverse of RB	W36ZG6FT64 0
isa	http://purl.bioontology.org/ontology/MESH/D007166 http://purl.bioontology.org/ontology/MESH/D000900 http://purl.bioontology.org/ontology/MESH/D000903 http://purl.bioontology.org/ontology/MESH/D000935
LT	TRD
Machine permutation	99; RAPAMYCIN (now SIROLIMUS) was indexed under POLYENES 1976-98
Mapped from	http://purl.bioontology.org/ontology/MESH/C488301 http://purl.bioontology.org/ontology/MESH/C081453 http://purl.bioontology.org/ontology/MESH/C492085 http://purl.bioontology.org/ontology/MESH/C085325 http://purl.bioontology.org/ontology/MESH/C489443 http://purl.bioontology.org/ontology/MESH/C401859 http://purl.bioontology.org/ontology/MESH/C117998 http://purl.bioontology.org/ontology/MESH/C578609 http://purl.bioontology.org/ontology/MESH/C514512 http://purl.bioontology.org/ontology/MESH/C539629 http://purl.bioontology.org/ontology/MESH/C000634228 http://purl.bioontology.org/ontology/MESH/C518022 http://purl.bioontology.org/ontology/MESH/C038313 http://purl.bioontology.org/ontology/MESH/C558961 http://purl.bioontology.org/ontology/MESH/C558962 http://purl.bioontology.org/ontology/MESH/C558963 http://purl.bioontology.org/ontology/MESH/C476498 http://purl.bioontology.org/ontology/MESH/C515074
MDA	19980611
MMR	20160701
MN	D02.540.505.760
notation	D020123
PA	D000903 D007166 D000900 D000935
prefLabel	Sirolimus
RR	53123-88-9 (Sirolimus)
TERMUI	T059902 T059904 T059903 T059901 T707737
TH	US NLM (2009) UK NLM (1999) CA FDA SRS (2014) ES USAN (19XX) INN (19XX) DE BAN (19XX) FR
tui	T109 T195 T121
subClassOf	http://purl.bioontology.org/ontology/MESH/D018942

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Mapping To	Ontology	Source
http://purl.bioontology.org/ontology/MSHFRE/D020123	MSHFRE	CUI
http://purl.bioontology.org/ontology/RXNORM/258355	RXNORM	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/116109004	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/MSHFRE/D020123	MSHFRE	CUI
http://purl.bioontology.org/ontology/PDQ/CDR0000042555	PDQ	CUI
http://purl.bioontology.org/ontology/LNC/LP21368-3	LOINC	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000148624	NDFRT	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387014003	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/RXNORM/35302	RXNORM	CUI
http://purl.bioontology.org/ontology/ATC/L01EG04	ATC	CUI
http://purl.bioontology.org/ontology/ATC/L04AA10	ATC	CUI
http://purl.bioontology.org/ontology/CSP/4005-0055	CRISP	CUI
http://purl.bioontology.org/ontology/VANDF/4021176	VANDF	CUI
http://purl.bioontology.org/ontology/ATC/S01XA23	ATC	CUI
http://purl.bioontology.org/ontology/MSHFRE/D020123	MSHFRE	CUI
http://purl.bioontology.org/ontology/SCTSPA/116109004	SCTSPA	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000006605	NDFRT	CUI
http://purl.bioontology.org/ontology/LNC/LA31622-6	LOINC	CUI
http://purl.bioontology.org/ontology/PDQ/CDR0000042555	PDQ	CUI
http://purl.bioontology.org/ontology/LNC/MTHU013897	LOINC	CUI
http://purl.bioontology.org/ontology/SCTSPA/387014003	SCTSPA	CUI
http://purl.bioontology.org/ontology/NDDF/007885	NDDF	CUI
http://purl.bioontology.org/ontology/PDQ/CDR0000042555	PDQ	CUI
http://purl.obolibrary.org/obo/CHEBI_9168	FYPO	LOOM
http://purl.obolibrary.org/obo/DRON_00013476	INBANCIDO	LOOM
http://purl.obolibrary.org/obo/DRON_00013476	CIDO	LOOM
http://purl.obolibrary.org/obo/DRON_00013476	ODNAE	LOOM
http://purl.bioontology.org/ontology/LNC/LP21368-3	LOINC	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148624	NDFRT	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387014003	SNOMEDCT	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148624	ODAE	LOOM
http://purl.bioontology.org/ontology/RXNORM/35302	RXNORM	LOOM
http://www.drugbank.ca/drugs/DB00877	FTC	LOOM
http://purl.bioontology.org/ontology/ATC/L01EG04	ATC	LOOM
http://www.semanticweb.org/osnathakimi/ontologies/deb#Sirolimus	DEB	LOOM
http://purl.obolibrary.org/obo/OMIT_0020049	OMIT	LOOM
http://purl.bioontology.org/ontology/ATC/L04AA10	ATC	LOOM
http://purl.bioontology.org/ontology/CSP/4005-0055	CRISP	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D020123	RH-MESH	LOOM
http://purl.obolibrary.org/obo/MESH_D020123	BERO	LOOM
http://purl.bioontology.org/ontology/VANDF/4021176	VANDF	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.540.505.760	RH-MESH	LOOM
http://purl.bioontology.org/ontology/ATC/S01XA23	ATC	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0072980	OCHV	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017172	PMAPP-PMO	LOOM
http://bmi.utah.edu/ontologies/hfontology/C0072980	HFO	LOOM
http://purl.bioontology.org/ontology/LNC/LA31622-6	LOINC	LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000042555	PDQ	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU013897	LOINC	LOOM
http://purl.obolibrary.org/obo/CHEBI_9168	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_9168	FIDEO	LOOM
http://purl.obolibrary.org/obo/CHEBI_9168	INBANCIDO	LOOM
http://purl.obolibrary.org/obo/CHEBI_9168	DINTO	LOOM
http://purl.obolibrary.org/obo/CHEBI_9168	EFO	LOOM
http://purl.obolibrary.org/obo/CHEBI_9168	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_9168	GO-PLUS	LOOM
http://purl.obolibrary.org/obo/CHEBI_9168	COVID-19	LOOM
http://purl.obolibrary.org/obo/CHEBI_9168	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_9168	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_9168	FYPO	LOOM
http://purl.obolibrary.org/obo/CHEBI_9168	CIDO	LOOM
http://purl.obolibrary.org/obo/CHEBI_9168	PHIPO	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#14738	OCHV	LOOM
http://purl.obolibrary.org/obo/NCIT_C1212	BERO	LOOM
https://go.drugbank.com/drugs/DB00877	MDM	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1212	NCIT	LOOM
http://purl.bioontology.org/ontology/NDDF/007885	NDDF	LOOM
http://purl.bioontology.org/ontology/CPT/80195	CPT	LOOM