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Last uploaded: January 31, 2024

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Preferred Name	Dactinomycin
Synonyms	Actinomycin D Cosmegen Lyovac, Cosmegen Meractinomycin LyovacCosmegen Lyovac-Cosmegen Cosmegen Lyovac Lyovac Cosmegen Actinomycin
Definitions	A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
ID	http://purl.bioontology.org/ontology/MESH/D003609
altLabel	Actinomycin D Cosmegen Lyovac, Cosmegen Meractinomycin LyovacCosmegen Lyovac-Cosmegen Cosmegen Lyovac Lyovac Cosmegen Actinomycin
AQL	AA AD AE AG AI AN BI BL CF CH CL CS EC HI IM IP ME PD PK PO RE SD ST TO TU UR
cui	C0701095 C0010934 C0001259
DC	1
definition	A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
DX	19660101
HN	66; ACTINOMYCIN was heading 1963-95
Inverse of AQ	http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000096 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000031 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000819 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000528
Inverse of RB	1CC1JFE158 0
isa	http://purl.bioontology.org/ontology/MESH/D011500 http://purl.bioontology.org/ontology/MESH/D000900 http://purl.bioontology.org/ontology/MESH/D000903 http://purl.bioontology.org/ontology/MESH/D019384
LT	TRD
Machine permutation	66; ACTINOMYCIN was heading 1963-95
Mapped from	http://purl.bioontology.org/ontology/MESH/C491688 http://purl.bioontology.org/ontology/MESH/C079337 http://purl.bioontology.org/ontology/MESH/C090021 http://purl.bioontology.org/ontology/MESH/C585829 http://purl.bioontology.org/ontology/MESH/C034904 http://purl.bioontology.org/ontology/MESH/C118278 http://purl.bioontology.org/ontology/MESH/C034859 http://purl.bioontology.org/ontology/MESH/C045936 http://purl.bioontology.org/ontology/MESH/C043207 http://purl.bioontology.org/ontology/MESH/C053038 http://purl.bioontology.org/ontology/MESH/C044144 http://purl.bioontology.org/ontology/MESH/C416122 http://purl.bioontology.org/ontology/MESH/C059346 http://purl.bioontology.org/ontology/MESH/C040943 http://purl.bioontology.org/ontology/MESH/C012204 http://purl.bioontology.org/ontology/MESH/C048014 http://purl.bioontology.org/ontology/MESH/C027847 http://purl.bioontology.org/ontology/MESH/C047851 http://purl.bioontology.org/ontology/MESH/C000717539 http://purl.bioontology.org/ontology/MESH/C064227 http://purl.bioontology.org/ontology/MESH/C080659 http://purl.bioontology.org/ontology/MESH/C080658 http://purl.bioontology.org/ontology/MESH/C586385 http://purl.bioontology.org/ontology/MESH/C037755 http://purl.bioontology.org/ontology/MESH/C038120 http://purl.bioontology.org/ontology/MESH/C002040 http://purl.bioontology.org/ontology/MESH/C003860 http://purl.bioontology.org/ontology/MESH/C010306 http://purl.bioontology.org/ontology/MESH/C041783 http://purl.bioontology.org/ontology/MESH/C033439 http://purl.bioontology.org/ontology/MESH/C037916 http://purl.bioontology.org/ontology/MESH/C053519 http://purl.bioontology.org/ontology/MESH/C015118 http://purl.bioontology.org/ontology/MESH/C044409 http://purl.bioontology.org/ontology/MESH/C052686 http://purl.bioontology.org/ontology/MESH/C052687 http://purl.bioontology.org/ontology/MESH/C054345 http://purl.bioontology.org/ontology/MESH/C038536 http://purl.bioontology.org/ontology/MESH/C004826 http://purl.bioontology.org/ontology/MESH/C090194 http://purl.bioontology.org/ontology/MESH/C041675 http://purl.bioontology.org/ontology/MESH/C051571 http://purl.bioontology.org/ontology/MESH/C096142 http://purl.bioontology.org/ontology/MESH/C025942 http://purl.bioontology.org/ontology/MESH/C110641 http://purl.bioontology.org/ontology/MESH/C107360 http://purl.bioontology.org/ontology/MESH/C039696 http://purl.bioontology.org/ontology/MESH/C049845 http://purl.bioontology.org/ontology/MESH/C010008 http://purl.bioontology.org/ontology/MESH/C010007 http://purl.bioontology.org/ontology/MESH/C008276 http://purl.bioontology.org/ontology/MESH/C036985 http://purl.bioontology.org/ontology/MESH/C074841 http://purl.bioontology.org/ontology/MESH/C072926 http://purl.bioontology.org/ontology/MESH/C042897 http://purl.bioontology.org/ontology/MESH/C077131 http://purl.bioontology.org/ontology/MESH/C033233 http://purl.bioontology.org/ontology/MESH/C033234 http://purl.bioontology.org/ontology/MESH/C034768 http://purl.bioontology.org/ontology/MESH/C533670 http://purl.bioontology.org/ontology/MESH/C056903 http://purl.bioontology.org/ontology/MESH/C069450 http://purl.bioontology.org/ontology/MESH/C000608363 http://purl.bioontology.org/ontology/MESH/C030013 http://purl.bioontology.org/ontology/MESH/C070420 http://purl.bioontology.org/ontology/MESH/C060752 http://purl.bioontology.org/ontology/MESH/C060751 http://purl.bioontology.org/ontology/MESH/C532166 http://purl.bioontology.org/ontology/MESH/C094496 http://purl.bioontology.org/ontology/MESH/C116800 http://purl.bioontology.org/ontology/MESH/C116801 http://purl.bioontology.org/ontology/MESH/C461384 http://purl.bioontology.org/ontology/MESH/C000278
MDA	19990101
MMR	20170524
MN	D03.633.300.200 D12.644.641.252 D04.345.566.252
notation	D003609
PA	D019384 D000903 D011500 D000900
prefLabel	Dactinomycin
RR	50-76-0 (Dactinomycin)
TERMUI	T010510 T010512 T010511 T010509 T605889 T010513 T641278
TH	USAN (1964) NLM (1996) US UK NL CA FDA SRS (2014) UNK (19XX) INN (19XX) DE AU USP (19XX) BAN (19XX)
tui	T195 T116
subClassOf	http://purl.bioontology.org/ontology/MESH/D010456 http://purl.bioontology.org/ontology/MESH/D006575

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Mapping To	Ontology	Source
http://purl.bioontology.org/ontology/RCD/x02YB	RCD	CUI
http://purl.bioontology.org/ontology/ATC/L01DA01	ATC	CUI
http://purl.bioontology.org/ontology/RXNORM/203599	RXNORM	CUI
http://purl.bioontology.org/ontology/PDQ/CDR0000039675	PDQ	CUI
http://purl.bioontology.org/ontology/CSP/0190-4841	CRISP	CUI
http://purl.bioontology.org/ontology/MSHFRE/D003609	MSHFRE	CUI
http://purl.bioontology.org/ontology/RXNORM/3100	RXNORM	CUI
http://purl.bioontology.org/ontology/SNMI/C-780A0	SNMI	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000146314	NDFRT	CUI
http://purl.bioontology.org/ontology/VANDF/4017964	VANDF	CUI
http://purl.bioontology.org/ontology/RCD/h21..	RCD	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387353003	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/NDDF/002657	NDDF	CUI
http://purl.bioontology.org/ontology/SCTSPA/64127001	SCTSPA	CUI
http://purl.bioontology.org/ontology/PDQ/CDR0000039675	PDQ	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/64127001	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/SCTSPA/387353003	SCTSPA	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000006852	NDFRT	CUI
http://purl.bioontology.org/ontology/CSP/0190-4841	CRISP	CUI
http://purl.bioontology.org/ontology/MSHFRE/D003609	MSHFRE	CUI
http://purl.bioontology.org/ontology/SNMI/C-780A0	SNMI	CUI
http://purl.bioontology.org/ontology/ATC/L01DA	ATC	CUI
http://purl.bioontology.org/ontology/HOIP/HOIP_0005146	HOIP	LOOM
http://purl.obolibrary.org/obo/MESH_D003609	BERO	LOOM
http://purl.bioontology.org/ontology/ATC/L01DA01	ATC	LOOM
http://purl.bioontology.org/ontology/RXNORM/3100	RXNORM	LOOM
http://purl.obolibrary.org/obo/dinto_DB00970	DINTO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D003609	RH-MESH	LOOM
http://doe-generated-ontology.com/OntoAD#C0010934	ONTOAD	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.644.641.252	RH-MESH	LOOM
http://purl.bioontology.org/ontology/SNMI/C-780A0	SNMI	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146314	NDFRT	LOOM
http://www.co-ode.org/ontologies/galen#Dactinomycin	GALEN	LOOM
http://purl.bioontology.org/ontology/VANDF/4017964	VANDF	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017960	PMAPP-PMO	LOOM
http://purl.obolibrary.org/obo/ARO_3000696	ARO	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#3600	OCHV	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387353003	SNOMEDCT	LOOM
http://purl.bioontology.org/ontology/NDDF/002657	NDDF	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.494.200	RH-MESH	LOOM
https://go.drugbank.com/drugs/DB00970	MDM	LOOM
http://purl.obolibrary.org/obo/TXPO_0005146	TXPO	LOOM
http://purl.jp/bio/4/id/200906027372813310	IOBC	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0010934	OCHV	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C412	NCIT	LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000039675	PDQ	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.345.566.252	RH-MESH	LOOM
http://purl.obolibrary.org/obo/NCIT_C412	COVID-19	LOOM
http://purl.obolibrary.org/obo/NCIT_C412	BERO	LOOM
http://purl.obolibrary.org/obo/OMIT_0004893	OMIT	LOOM