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Last uploaded: January 31, 2024

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Preferred Name	Fibroblast Growth Factor 1
Synonyms	Class I Heparin-Binding Growth Factor
Definitions	A 17-kDa single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. It binds to HEPARIN, which potentiates its biological activity and protects it from proteolysis. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages, and also has chemotactic and mitogenic activities. It was originally named acidic fibroblast growth factor based upon its chemical properties and to distinguish it from basic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 2).
ID	http://purl.bioontology.org/ontology/MESH/D016220
altLabel	Class I Heparin-Binding Growth Factor Heparin-Binding Growth Factor, Class I HBGF-1 FGF-1 Fibroblast growth factor (human brain acidic protein moiety reduced) Fibroblast Growth Factor-1 Heparin Binding Growth Factor, Class I Acidic Fibroblast Growth Factor Fibroblast Growth Factor, Acidic FGF1 Heparin-Binding Fibroblast Growth Factor Class I
AQL	AA AD AE AG AI AN BI BL CF CH CL CS DE DF EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UL UR
cui	C0079349
DC	1
definition	A 17-kDa single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. It binds to HEPARIN, which potentiates its biological activity and protects it from proteolysis. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages, and also has chemotactic and mitogenic activities. It was originally named acidic fibroblast growth factor based upon its chemical properties and to distinguish it from basic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 2).
DX	19910101
HN	2002(1991); for FIBROBLAST GROWTH FACTOR-1 use FIBROBLAST GROWTH FACTOR 1(NM) 1998-2001
Inverse of AQ	http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000096 http://purl.bioontology.org/ontology/MESH/Q000172 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000648 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000031 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000819 http://purl.bioontology.org/ontology/MESH/Q000502 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000187 http://purl.bioontology.org/ontology/MESH/Q000235 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000528
Inverse of RB	104781-85-3
Machine permutation	2002; FIBROBLAST GROWTH FACTOR-1 was indexed under FIBROBLAST GROWTH FACTOR ACIDIC 2001, FIBROBLAST GROWTH FACTOR 2000-2001 & under FIBROBLAST GROWTH FACTOR, BASIC 1998-2000
Mapped from	http://purl.bioontology.org/ontology/MESH/C557087 http://purl.bioontology.org/ontology/MESH/C103063 http://purl.bioontology.org/ontology/MESH/C554637 http://purl.bioontology.org/ontology/MESH/C480524 http://purl.bioontology.org/ontology/MESH/C121515 http://purl.bioontology.org/ontology/MESH/C422626 http://purl.bioontology.org/ontology/MESH/C083453
MDA	19900705
MMR	20060705
MN	D12.644.276.624.110 D23.529.624.110 D12.776.467.624.110
notation	D016220
prefLabel	Fibroblast Growth Factor 1
TERMUI	T048282 T048281 T048285 T326075 T326074 T440828 T326073 T048286 T048283 T048284
TH	NLM (2002) NLM (1991)
tui	T116 T123
subClassOf	http://purl.bioontology.org/ontology/MESH/D005346

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Mapping To	Ontology	Source
http://purl.bioontology.org/ontology/CSP/1354-9572	CRISP	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000171006	NDFRT	CUI
http://purl.bioontology.org/ontology/MSHFRE/D016220	MSHFRE	CUI
http://purl.bioontology.org/ontology/RXNORM/1591916	RXNORM	CUI
http://purl.obolibrary.org/obo/PR_000007479	OBA	LOOM
http://purl.bioontology.org/ontology/OMIM/131220	OMIM	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D23.529.624.110	RH-MESH	LOOM
http://purl.uniprot.org/uniprot/P05230	FTC	LOOM
http://id.nlm.nih.gov/mesh/D016220	MDM	LOOM
http://purl.obolibrary.org/obo/NCIT_C20548	BERO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.776.467.624.110	RH-MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D016220	RH-MESH	LOOM
http://www.ncbi.nlm.nih.gov/gene/14164	NIFSTD	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20548	NCIT	LOOM
http://purl.obolibrary.org/obo/OMIT_0016760	OMIT	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0079349	OCHV	LOOM
http://purl.obolibrary.org/obo/PR_000007479	PR	LOOM
http://purl.obolibrary.org/obo/dinto_3506	DINTO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.644.276.624.110	RH-MESH	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00021468	PMAPP-PMO	LOOM
http://purl.obolibrary.org/obo/MESH_D016220	BERO	LOOM
https://go.drugbank.com/drugs/DB05599	MDM	LOOM
http://purl.bioontology.org/ontology/RXNORM/1591916	RXNORM	LOOM