loading...| Preferred Name |
Pentostatin |
|
| Synonyms |
CI 825 |
|
| Definitions |
A potent inhibitor of ADENOSINE DEAMINASE. The drug induces APOPTOSIS of LYMPHOCYTES, and is used in the treatment of many lymphoproliferative malignancies, particularly HAIRY CELL LEUKEMIA. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity. |
|
| ID |
http://purl.bioontology.org/ontology/MESH/D015649 |
|
| altLabel |
CI 825 Nipent Imidazo(4,5-d)(1,3)diazepin-8-ol, 3-(2-deoxy-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydro-, (8R)- 2' Deoxycoformycin 2'-Deoxycoformycin CI-825 NSC 218321 Imidazo(4,5-d)(1,3)diazepin-8-ol, 3-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydro-, (R)- NSC218321 NSC-218321 CI825 Co-Vidarabine Deoxycoformycin |
|
| AQL |
AA AD AE AG AI AN BI BL CF CH CL CS EC HI IM IP ME PD PK PO RE SD ST TO TU UR |
|
| cui |
C0733529 C0733531 C0591865 C0733530 C0030896 |
|
| DC |
1 |
|
| definition |
A potent inhibitor of ADENOSINE DEAMINASE. The drug induces APOPTOSIS of LYMPHOCYTES, and is used in the treatment of many lymphoproliferative malignancies, particularly HAIRY CELL LEUKEMIA. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity. |
|
| DX |
19900101 |
|
| HN |
1997 (1990); for CO-VIDARABINE use PENTOSTATIN 1982-1997 |
|
| Inverse of AQ |
http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000096 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000031 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000819 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 |
|
| Inverse of RB |
395575MZO7 0 |
|
| isa | ||
| LT |
TRD |
|
| Machine permutation |
1997; CO-VIDARABINE (now PENTOSTATIN) was indexed under VIDARABINE/*analogs & derivatives 1976-97 |
|
| Mapped from |
http://purl.bioontology.org/ontology/MESH/C022803 http://purl.bioontology.org/ontology/MESH/C046686 |
|
| MDA |
19890525 |
|
| MMR |
20190701 |
|
| MN |
D13.570.685.350.200.700 D13.570.230.677 D03.383.742.680.350.200.700 |
|
| notation |
D015649 |
|
| PA |
D000970 D058892 |
|
| prefLabel |
Pentostatin |
|
| RR |
53910-25-1 (Pentostatin) |
|
| TERMUI |
T046288 T046291 T000942550 T046290 T046289 T614059 T770716 T046287 |
|
| TH |
US UK NL NLM (1990) FDA SRS (2014) NLM (2019) ES INN (19XX) DE NLM (2011) USAN (1977) BAN (19XX) FR |
|
| tui |
T195 T114 T121 |
|
| subClassOf |