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Last uploaded: January 31, 2024

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Preferred Name	Histamine H1 Antagonists
Synonyms	Histamine H1 Blockers H1 Receptor Blockaders
Definitions	Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.
ID	http://purl.bioontology.org/ontology/MESH/D006634
altLabel	Histamine H1 Blockers Histamine H1 Receptor Antagonist H1 Antihistaminics Antagonist, Histamine H1 Antihistamines, Sedating Antihistamines, Classical H1 Antagonists, Histamine Antihistaminics, H1 Histamine H1 Antagonist Sedating Antihistamines H1 Antagonist, Histamine Antagonists, Histamine H1 Receptor Histamine H1 Receptor Blockaders Receptor Blockaders, H1 Antihistaminics, Classical Classical Antihistaminics Histamine H1 Receptor Antagonists Blockaders, Histamine H1 Receptor First Generation H1 Antagonists Antagonists, Histamine H1 Classical Antihistamines H1 Receptor Blockaders
AN	HISTAMINE H1 ANTAGONISTS, NON-SEDATING is also available
AQL	AD AE AN BL CF CH CL CS EC HI IM IP ME PD PK PO RE SD ST TO TU UR
cui	C1955826 C0019592
DC	1
definition	Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.
DX	19770101
FX	D001993 D006969 D018926
HN	95; was HISTAMINE H1 RECEPTOR BLOCKADERS 1977-94; was ANTIHISTAMINICS 1963-76; ANTIHISTAMINICS, CLASSICAL was ANTIHISTAMINICS see HISTAMINE H1 RECEPTOR BLOCKADERS 1977-90
Inverse of AQ	http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000528
Inverse of isa	http://purl.bioontology.org/ontology/MESH/C043345 http://purl.bioontology.org/ontology/MESH/C009093 http://purl.bioontology.org/ontology/MESH/D000865 http://purl.bioontology.org/ontology/MESH/C004664 http://purl.bioontology.org/ontology/MESH/C006069 http://purl.bioontology.org/ontology/MESH/D004111 http://purl.bioontology.org/ontology/MESH/D004115 http://purl.bioontology.org/ontology/MESH/D002936 http://purl.bioontology.org/ontology/MESH/D008803 http://purl.bioontology.org/ontology/MESH/C031242 http://purl.bioontology.org/ontology/MESH/D008701 http://purl.bioontology.org/ontology/MESH/D000078785 http://purl.bioontology.org/ontology/MESH/D007665 http://purl.bioontology.org/ontology/MESH/D001977 http://purl.bioontology.org/ontology/MESH/D006919 http://purl.bioontology.org/ontology/MESH/C005430 http://purl.bioontology.org/ontology/MESH/C006399 http://purl.bioontology.org/ontology/MESH/C035385 http://purl.bioontology.org/ontology/MESH/D011738 http://purl.bioontology.org/ontology/MESH/C053090 http://purl.bioontology.org/ontology/MESH/C004649 http://purl.bioontology.org/ontology/MESH/C020486 http://purl.bioontology.org/ontology/MESH/D014309 http://purl.bioontology.org/ontology/MESH/D004319 http://purl.bioontology.org/ontology/MESH/C004454 http://purl.bioontology.org/ontology/MESH/C058249 http://purl.bioontology.org/ontology/MESH/C049111 http://purl.bioontology.org/ontology/MESH/C015408 http://purl.bioontology.org/ontology/MESH/D003533 http://purl.bioontology.org/ontology/MESH/C049054 http://purl.bioontology.org/ontology/MESH/C027172 http://purl.bioontology.org/ontology/MESH/C058251 http://purl.bioontology.org/ontology/MESH/D005444 http://purl.bioontology.org/ontology/MESH/C015121 http://purl.bioontology.org/ontology/MESH/C022028 http://purl.bioontology.org/ontology/MESH/C500082 http://purl.bioontology.org/ontology/MESH/C100220 http://purl.bioontology.org/ontology/MESH/D004155 http://purl.bioontology.org/ontology/MESH/C001941 http://purl.bioontology.org/ontology/MESH/C003722 http://purl.bioontology.org/ontology/MESH/D003501 http://purl.bioontology.org/ontology/MESH/C013373 http://purl.bioontology.org/ontology/MESH/C018904 http://purl.bioontology.org/ontology/MESH/D011398 http://purl.bioontology.org/ontology/MESH/D014311 http://purl.bioontology.org/ontology/MESH/C005715 http://purl.bioontology.org/ontology/MESH/C100113 http://purl.bioontology.org/ontology/MESH/D010632 http://purl.bioontology.org/ontology/MESH/C042395 http://purl.bioontology.org/ontology/MESH/D002744 http://purl.bioontology.org/ontology/MESH/C557708 http://purl.bioontology.org/ontology/MESH/D002974 http://purl.bioontology.org/ontology/MESH/C480616 http://purl.bioontology.org/ontology/MESH/C480617 http://purl.bioontology.org/ontology/MESH/D008468 http://purl.bioontology.org/ontology/MESH/C012293 http://purl.bioontology.org/ontology/MESH/C038303 http://purl.bioontology.org/ontology/MESH/C006656
Inverse of RB	0
Inverse of RO	http://purl.bioontology.org/ontology/MESH/D006969 http://purl.bioontology.org/ontology/MESH/D018926 http://purl.bioontology.org/ontology/MESH/D001993 http://purl.bioontology.org/ontology/MESH/D006993
Machine permutation	95; was HISTAMINE H1 RECEPTOR BLOCKADERS 1977-94; was ANTIHISTAMINICS 1963-76; ANTIHISTAMINICS, CLASSICAL was ANTIHISTAMINICS see HISTAMINE H1 RECEPTOR BLOCKADERS 1977-90
MDA	19760505
MMR	20210630
MN	D27.505.519.625.375.425.400 D27.505.696.577.375.425.400
notation	D006634
OL	use HISTAMINE H1 ANTAGONISTS to search HISTAMINE H1 RECEPTOR BLOCKADERS 1977-94 and ANTIHISTAMINICS 1966-76
prefLabel	Histamine H1 Antagonists
TERMUI	T019976 T721916 T019974 T019970 T019979 T686140 T019971 T001089189 T019968 T019978 T019972 T019977 T001089188 T019973 T019975 T019969
TH	NLM (2009) NLM (1993) NLM (1977) NLM (1991) NLM (1995) NLM (2008) NLM (1990) UNK (19XX) NLM (2022)
tui	T109 T121
subClassOf	http://purl.bioontology.org/ontology/MESH/D006633

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Mapping To	Ontology	Source
http://purl.bioontology.org/ontology/MSHFRE/D006634	MSHFRE	CUI
http://purl.bioontology.org/ontology/MSHFRE/D006634	MSHFRE	CUI
http://purl.bioontology.org/ontology/RCD/x01Dr	RCD	CUI
http://purl.bioontology.org/ontology/SCTSPA/373228009	SCTSPA	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/349955005	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/RCD/x01Dn	RCD	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/373228009	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/SCTSPA/349955005	SCTSPA	CUI
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D006634	RH-MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D27.505.519.625.375.425.400	RH-MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D27.505.696.577.375.425.400	RH-MESH	LOOM
http://doe-generated-ontology.com/OntoAD#C0019592	ONTOAD	LOOM
http://purl.obolibrary.org/obo/MESH_D006634	BERO	LOOM
http://purl.obolibrary.org/obo/OMIT_0007793	OMIT	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00024662	PMAPP-PMO	LOOM