loading...| Preferred Name |
Cataplexy |
|
| Synonyms |
cataplexy 猝倒 |
|
| ID |
http://www.tcmkg.com/ISPO/ISPO_00002137 |
|
| database_cross_reference |
SYMP:0000408 |
|
| definition |
A condition characterized by transient weakness or paralysis of somatic musculature triggered by an emotional stimulus or physical exertion. Cataplexy is frequently associated with NARCOLEPSY. During a cataplectic attack, there is a marked reduction in muscle tone similar to the normal physiologic hypotonia that accompanies rapid eye movement sleep (SLEEP, REM). (From Adams et al., Principles of Neurology, 6th ed, p396) Cataplexy is a sudden and transient episode of muscle weakness accompanied by full conscious awareness, typically triggered by emotions such as laughing, crying, or terror. Cataplexy affects approximately 70% of people who have narcolepsy, and is caused by an autoimmune destruction of hypothalamic neurons that produce the neuropeptide hypocretin , which regulates arousal and has a role in stabilization of the transition between wake and sleep states. Cataplexy without narcolepsy is rare and the cause is unknown. 异相睡眠障碍。发作时全身肌肉张力突然消失，病人摔倒好像是从清醒状态突然进入异相睡眠阶段，持续几秒钟甚至几分钟。可以看作是发作性睡眠的一种表现形式，但又不同于发作性睡病。情绪变化是主要诱发因素，如生气、大笑，或突然完成某一动作，如试图抓住从身边飞过的物体等。有研究表明，它与宗族遗传有关。苯丙胺、丙咪嗪等精神药物有一定的治疗作用，说明此类病人需增强脑内单胺类神经递质功能。苯丙胺可促进单胺类递质的释放，丙咪嗪可抑制突触间隙中单胺类递质的浓度增高，从而提高神经信息的传递功能。两种药物的疗效说明，此病与异相睡眠脑化学机制障碍有关。 |
|
| has_exact_synonym |
cataplexy 猝倒 |
|
| has_obo_namespace |
symptoms |
|
| id |
ISPO:00002137 |
|
| label |
Cataplexy |
|
| notation |
ISPO:00002137 |
|
| prefLabel |
Cataplexy |
|
| subClassOf |