loading...| Preferred Name |
Class I MHC mediated antigen processing & presentation |
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| Synonyms |
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| Definitions |
Major histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular bacteria or tumor-associated antigens. They bind peptide fragments of these proteins and presenting them to CD8+ T cells at the cell surface. This enables cytotoxic T cells to identify and eliminate cells that are synthesizing abnormal or foreign proteins. MHC class I is a trimeric complex composed of a polymorphic heavy chain (HC or alpha chain) and an invariable light chain, known as beta2-microglobulin (B2M) plus an 8-10 residue peptide ligand. Represented here are the events in the biosynthesis of MHC class I molecules, including generation of antigenic peptides by the ubiquitin/26S-proteasome system, delivery of these peptides to the endoplasmic reticulum (ER), loading of peptides to MHC class I molecules and display of MHC class I complexes on the cell surface. Reviewed: Elliott, T, 2011-02-10 Authored: Garapati, P V, 2010-10-29 Edited: Garapati, P V, 2010-10-29 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0022374 |
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| comment |
Major histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular bacteria or tumor-associated antigens. They bind peptide fragments of these proteins and presenting them to CD8+ T cells at the cell surface. This enables cytotoxic T cells to identify and eliminate cells that are synthesizing abnormal or foreign proteins. MHC class I is a trimeric complex composed of a polymorphic heavy chain (HC or alpha chain) and an invariable light chain, known as beta2-microglobulin (B2M) plus an 8-10 residue peptide ligand. Represented here are the events in the biosynthesis of MHC class I molecules, including generation of antigenic peptides by the ubiquitin/26S-proteasome system, delivery of these peptides to the endoplasmic reticulum (ER), loading of peptides to MHC class I molecules and display of MHC class I complexes on the cell surface. Reviewed: Elliott, T, 2011-02-10 Authored: Garapati, P V, 2010-10-29 Edited: Garapati, P V, 2010-10-29 |
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| definition source |
Pubmed17055423 Pubmed12495737 Pubmed18641646 Pubmed18926908 Reactome, http://www.reactome.org Pubmed18243674 Pubmed19261456 Pubmed17145306 Pubmed8717519 |
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| label |
Class I MHC mediated antigen processing & presentation |
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| located_in | ||
| prefixIRI |
HINO:0022374 |
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| prefLabel |
Class I MHC mediated antigen processing & presentation |
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| seeAlso |
Reactome Database ID Release 43983169 ReactomeREACT_75820 GENE ONTOLOGYGO:0002474 |
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| subClassOf | ||
| has_part |
http://purl.obolibrary.org/obo/HINO_0022372 |