loading...| Preferred Name |
Cytosolic sensors of pathogen-associated DNA |
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| Definitions |
Reviewed: D'Eustachio, P, 2011-12-07 Reviewed: Upton, JW, Mocarski, ES, 2012--0-2- Edited: Shamovsky, V, 2012-02-23 Authored: Shamovsky, V, 2011-09-21 Presence of pathogen-associated DNA in cytosol induces type I IFN production. Several intracellular receptors have been implicated to some degree. These include DNA-dependent activator of interferon (IFN)-regulatory factors (DAI) (also called Z-DNA-binding protein 1, ZBP1), absent in melanoma 2 (AIM2), RNA polymerase III (Pol III), leucine-rich repeat flightless interacting protein-1 (Lrrfip1), DExD/H box helicases (DHX9 and DHX36), and the IFN-inducible protein IFI16.<p>Detection of cytosolic DNA requires multiple and possibly redundant sensors leading to activation of the transcription factor NF-kappaB and TBK1-mediated phosphorylation of the transcription factor IRF3. Cytosolic DNA also activates caspase-1-dependent maturation of the pro-inflammatory cytokines interleukin (IL)-1beta and IL-18. This pathway is mediated by AIM2. |
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| ID |
http://purl.obolibrary.org/obo/HINO_0022265 |
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Reviewed: D'Eustachio, P, 2011-12-07 Reviewed: Upton, JW, Mocarski, ES, 2012--0-2- Edited: Shamovsky, V, 2012-02-23 Authored: Shamovsky, V, 2011-09-21 Presence of pathogen-associated DNA in cytosol induces type I IFN production. Several intracellular receptors have been implicated to some degree. These include DNA-dependent activator of interferon (IFN)-regulatory factors (DAI) (also called Z-DNA-binding protein 1, ZBP1), absent in melanoma 2 (AIM2), RNA polymerase III (Pol III), leucine-rich repeat flightless interacting protein-1 (Lrrfip1), DExD/H box helicases (DHX9 and DHX36), and the IFN-inducible protein IFI16. Detection of cytosolic DNA requires multiple and possibly redundant sensors leading to activation of the transcription factor NF-kappaB and TBK1-mediated phosphorylation of the transcription factor IRF3. Cytosolic DNA also activates caspase-1-dependent maturation of the pro-inflammatory cytokines interleukin (IL)-1beta and IL-18. This pathway is mediated by AIM2. |
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| definition source |
Reactome, http://www.reactome.org Pubmed21533068 |
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Cytosolic sensors of pathogen-associated DNA |
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HINO:0022265 |
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Cytosolic sensors of pathogen-associated DNA |
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| seeAlso |
GENE ONTOLOGYGO:0032481 Reactome Database ID Release 431834949 ReactomeREACT_118823 |
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