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Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 |
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| Definitions |
has a Stoichiometric coefficient of 2 Authored: Heldin, CH, Moustakas, A, Huminiecki, L, Jassal, B, 2006-02-02 Reviewed: Heldin, CH, 2006-04-18 14:26:12 Reviewed: Chen, Ye-Guang, 2012-11-14 Reviewed: Huang, Tao, 2012-05-14 The phosphorylated C-terminal tail of R-SMAD induces a conformational change in the MH2 domain (Qin et al. 2001, Chacko et al. 2004), which now acquires high affinity towards Co-SMAD i.e. SMAD4 (common mediator of signal transduction in TGF-beta/BMP signaling). The R-SMAD:Co-SMAD complex (Nakao et al. 1997) most likely is a trimer of two R-SMADs with one Co-SMAD (Kawabata et al. 1998). It is important to note that the Co-SMAD itself cannot be phosphorylated as it lacks the C-terminal serine motif. Edited: Jassal, B, 2012-04-10 Edited: Jassal, B, 2006-01-18 10:19:52 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0019761 |
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| comment |
has a Stoichiometric coefficient of 2 Authored: Heldin, CH, Moustakas, A, Huminiecki, L, Jassal, B, 2006-02-02 Reviewed: Heldin, CH, 2006-04-18 14:26:12 Reviewed: Chen, Ye-Guang, 2012-11-14 Reviewed: Huang, Tao, 2012-05-14 The phosphorylated C-terminal tail of R-SMAD induces a conformational change in the MH2 domain (Qin et al. 2001, Chacko et al. 2004), which now acquires high affinity towards Co-SMAD i.e. SMAD4 (common mediator of signal transduction in TGF-beta/BMP signaling). The R-SMAD:Co-SMAD complex (Nakao et al. 1997) most likely is a trimer of two R-SMADs with one Co-SMAD (Kawabata et al. 1998). It is important to note that the Co-SMAD itself cannot be phosphorylated as it lacks the C-terminal serine motif. Edited: Jassal, B, 2012-04-10 Edited: Jassal, B, 2006-01-18 10:19:52 |
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| definition source |
Pubmed11779503 Pubmed9670020 Pubmed15350224 Reactome, http://www.reactome.org Pubmed11779505 Pubmed9311995 |
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Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 |
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| prefixIRI |
HINO:0019761 |
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| prefLabel |
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 |
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| seeAlso |
Reactome Database ID Release 43170847 ReactomeREACT_6760 |
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