loading...| Preferred Name |
Abacavir metabolism |
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| Definitions |
Edited: D'Eustachio, P, 2012-03-16 Reviewed: Jassal, B, 2012-03-16 Authored: D'Eustachio, P, 2012-03-14 Abacavir activation proceeds steps of phosphorylation, deamination to yield carbovir monophosphate, and phosphorylation of the latter compound to yield the triphosphate. In addition, abacavir can be conjugated with glucuronide or oxidized to its 5'-carboxylate derivative, the two major forms in which it is excreted from the body (Yuen et al. 2008). |
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| ID |
http://purl.obolibrary.org/obo/HINO_0016388 |
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| comment |
Edited: D'Eustachio, P, 2012-03-16 Reviewed: Jassal, B, 2012-03-16 Authored: D'Eustachio, P, 2012-03-14 Abacavir activation proceeds steps of phosphorylation, deamination to yield carbovir monophosphate, and phosphorylation of the latter compound to yield the triphosphate. In addition, abacavir can be conjugated with glucuronide or oxidized to its 5'-carboxylate derivative, the two major forms in which it is excreted from the body (Yuen et al. 2008). |
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| definition source |
Pubmed18479171 Reactome, http://www.reactome.org |
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| label |
Abacavir metabolism |
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| prefixIRI |
HINO:0016388 |
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| prefLabel |
Abacavir metabolism |
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| seeAlso |
Reactome Database ID Release 432161541 ReactomeREACT_121388 GENE ONTOLOGYGO:0017144 |
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| has_part |
http://purl.obolibrary.org/obo/HINO_0025321 http://purl.obolibrary.org/obo/HINO_0025313 http://purl.obolibrary.org/obo/HINO_0025312 http://purl.obolibrary.org/obo/HINO_0025316 http://purl.obolibrary.org/obo/HINO_0025314 |