loading...| Preferred Name |
Activation of Chaperones by ATF6-alpha |
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| Synonyms |
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| Definitions |
Reviewed: D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31 Reviewed: Urano, F, 2010-04-30 Edited: May, B, Gopinathrao, G, 2008-11-19 19:22:37 ATF6-alpha is a transmembrane protein that normally resides in the Endoplasmic Reticulum (ER) membrane. Here its luminal C-terminal domain is associated with BiP, shielding 2 Golgi-targeting regions and thus keeping ATF6-alpha in the ER. Upon interaction of BiP with unfolded proteins in the ER, ATF6-alpha dissociates and transits to the Golgi where it is cleaved by the S1P and S2P proteases that reside in the Golgi, releasing the N-terminal domain of ATF6-alpha into the cytosol. After transiting to the nucleus, the N-terminal domain acts as a transcription factor to activate genes encoding chaperones. Authored: May, B, 2009-06-02 00:51:49 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0016048 |
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| comment |
Reviewed: D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31 Reviewed: Urano, F, 2010-04-30 Edited: May, B, Gopinathrao, G, 2008-11-19 19:22:37 ATF6-alpha is a transmembrane protein that normally resides in the Endoplasmic Reticulum (ER) membrane. Here its luminal C-terminal domain is associated with BiP, shielding 2 Golgi-targeting regions and thus keeping ATF6-alpha in the ER. Upon interaction of BiP with unfolded proteins in the ER, ATF6-alpha dissociates and transits to the Golgi where it is cleaved by the S1P and S2P proteases that reside in the Golgi, releasing the N-terminal domain of ATF6-alpha into the cytosol. After transiting to the nucleus, the N-terminal domain acts as a transcription factor to activate genes encoding chaperones. Authored: May, B, 2009-06-02 00:51:49 |
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| definition source |
Pubmed18048764 Reactome, http://www.reactome.org Pubmed18038217 Pubmed18436705 |
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| label |
Activation of Chaperones by ATF6-alpha |
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| prefixIRI |
HINO:0016048 |
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| prefLabel |
Activation of Chaperones by ATF6-alpha |
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| seeAlso |
GENE ONTOLOGYGO:0006987 ReactomeREACT_18348 Reactome Database ID Release 43381033 |
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| has_part |
http://purl.obolibrary.org/obo/HINO_0016051 http://purl.obolibrary.org/obo/HINO_0008879 http://purl.obolibrary.org/obo/HINO_0008876 http://purl.obolibrary.org/obo/HINO_0008875 |