loading...| Preferred Name |
Phosphate bond hydrolysis by NUDT proteins |
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| Synonyms |
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| Definitions |
Enzymes that belong to the NUDT (Nudix) superfamily catalyze the hydrolysis of phosphodiester bonds in molecules including nucleoside triphosphates and diphosphates and nucleotide sugars. Family members are defined by the presence of an amino acid sequence motif shared with the E. coli MutT gene product, and are involved in diverse physiological processes (Mildvan et al. 2005; McLennan 2006). The hydrolysis of nucleoside di and triphosphates whose purine bases have been oxidized or deaminated may protect the cell from the mutational damage that would occur if modified deoxyribonucleotides were incorporated into DNA and from the aberrant protein synthesis that would occur if modified ribonucleotides were incorporated into mRNA (Iyama et al. 2010; Takagi et al. 2012). The hydrolysis of ADP ribose may prevent the aberrant spontaneous ADP ribosylation of cellular proteins that could occur were this molecule to accumulate to high levels in the cell (Perraud et al. 2003; Shen et al. 2003). Reviewed: Ito, Riyoko, 2012-10-05 Edited: D'Eustachio, P, 2012-07-06 Authored: D'Eustachio, P, 2012-07-06 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0014450 |
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| comment |
Enzymes that belong to the NUDT (Nudix) superfamily catalyze the hydrolysis of phosphodiester bonds in molecules including nucleoside triphosphates and diphosphates and nucleotide sugars. Family members are defined by the presence of an amino acid sequence motif shared with the E. coli MutT gene product, and are involved in diverse physiological processes (Mildvan et al. 2005; McLennan 2006). The hydrolysis of nucleoside di and triphosphates whose purine bases have been oxidized or deaminated may protect the cell from the mutational damage that would occur if modified deoxyribonucleotides were incorporated into DNA and from the aberrant protein synthesis that would occur if modified ribonucleotides were incorporated into mRNA (Iyama et al. 2010; Takagi et al. 2012). The hydrolysis of ADP ribose may prevent the aberrant spontaneous ADP ribosylation of cellular proteins that could occur were this molecule to accumulate to high levels in the cell (Perraud et al. 2003; Shen et al. 2003). Reviewed: Ito, Riyoko, 2012-10-05 Edited: D'Eustachio, P, 2012-07-06 Authored: D'Eustachio, P, 2012-07-06 |
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| definition source |
Pubmed20385596 Reactome, http://www.reactome.org Pubmed15581572 Pubmed16378245 Pubmed12948489 Pubmed22556419 Pubmed12427752 |
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| label |
Phosphate bond hydrolysis by NUDT proteins |
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| located_in | ||
| prefixIRI |
HINO:0014450 |
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| prefLabel |
Phosphate bond hydrolysis by NUDT proteins |
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| seeAlso |
GENE ONTOLOGYGO:0034656 Reactome Database ID Release 432393930 ReactomeREACT_150237 |
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| subClassOf | ||
| has_part |
http://purl.obolibrary.org/obo/HINO_0003615 http://purl.obolibrary.org/obo/HINO_0003616 http://purl.obolibrary.org/obo/HINO_0003613 http://purl.obolibrary.org/obo/HINO_0003607 http://purl.obolibrary.org/obo/HINO_0003602 http://purl.obolibrary.org/obo/HINO_0003604 http://purl.obolibrary.org/obo/HINO_0003608 http://purl.obolibrary.org/obo/HINO_0003605 http://purl.obolibrary.org/obo/HINO_0003603 http://purl.obolibrary.org/obo/HINO_0003606 |