Human Interaction Network Ontology

Last uploaded: June 27, 2014
Preferred Name

Proteolysis of the IGF:IGFBP-3:ALS Complex by Prostate-specific Antigen

Synonyms
Definitions

Reviewed: D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31 Edited: May, B, Gopinathrao, G, 2008-11-19 20:02:07 Prostate specific Antigen (PSA) cleaves IGFBP-3 in the IGF:IGFBP-3:ALS Complex between amino acids 186 and 187. Other cleavage sites were observed but not reproducibly. These may have been caused by impurities in the PSA preparation.

ID

http://purl.obolibrary.org/obo/HINO_0008765

comment

Reviewed: D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31

Edited: May, B, Gopinathrao, G, 2008-11-19 20:02:07

Prostate specific Antigen (PSA) cleaves IGFBP-3 in the IGF:IGFBP-3:ALS Complex between amino acids 186 and 187. Other cleavage sites were observed but not reproducibly. These may have been caused by impurities in the PSA preparation.

definition source

Pubmed7525824

Pubmed11751371

Pubmed7525634

Pubmed1383255

Pubmed12379487

Reactome, http://www.reactome.org

Pubmed12466191

Pubmed8817670

Pubmed7538844

Pubmed10218588

Pubmed17047378

has input

http://purl.obolibrary.org/obo/HINO_0017493

has output

http://purl.obolibrary.org/obo/UniProt_P17936

http://purl.obolibrary.org/obo/UniProt_P35858

http://purl.obolibrary.org/obo/HINO_0026720

label

Proteolysis of the IGF:IGFBP-3:ALS Complex by Prostate-specific Antigen

prefixIRI

HINO:0008765

prefLabel

Proteolysis of the IGF:IGFBP-3:ALS Complex by Prostate-specific Antigen

seeAlso

ReactomeREACT_15465

EC Number: 3.4.21

Reactome Database ID Release 43381466

subClassOf

http://purl.obolibrary.org/obo/INO_0000040

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