IGF2BP1 Binds Specific RNA Molecules

Reviewed: Chao, JA, 2010-05-30 Insulin-like Growth Factor mRNA Binding Factor-1 (IGF2BP1, also known as ZBP1, CRD-BP, IMP1, and VICKZ1) binds several specific RNAs containing the sequence motif CAUH (where H is A, C, or U). Binding causes stabilization and subcellular localization of the RNA.<br>Isoforms of IGF2 mRNA containing leader-3 are bound by IGF2BP1 at the 5' UTR, repressing translation (other isoforms of IGF2 are constitutive).<br>ZBP1 (IGF2BP1) uses its third and fourth KH domains to recognize the first 28 nts of the 3? UTR of Beta?actin mRNA. The KH domains are arranged as an anti-parallel pseudo-dimer that specifically recognize a bipartite element located in this RNA sequence.<br>MYC (c-MYC) and Beta-TRCP1 mRNAs are bound at sites termed Coding Region Determinants (CDRs) in the open reading frame of the message. Binding of the MYC mRNA shields it from degradation and increases its half-life<br> The CD44 mRNA is bound at the 3' UTR.<br>IGF2BP1 also binds the non-coding, imprinted H19 RNA. Edited: May, B, 2009-07-04 Authored: May, B, 2009-07-04 Reviewed: Singer, RH, 2010-05-30

http://purl.obolibrary.org/obo/HINO_0008761

Reviewed: Chao, JA, 2010-05-30

Insulin-like Growth Factor mRNA Binding Factor-1 (IGF2BP1, also known as ZBP1, CRD-BP, IMP1, and VICKZ1) binds several specific RNAs containing the sequence motif CAUH (where H is A, C, or U). Binding causes stabilization and subcellular localization of the RNA.
Isoforms of IGF2 mRNA containing leader-3 are bound by IGF2BP1 at the 5' UTR, repressing translation (other isoforms of IGF2 are constitutive).
ZBP1 (IGF2BP1) uses its third and fourth KH domains to recognize the first 28 nts of the 3? UTR of Beta?actin mRNA. The KH domains are arranged as an anti-parallel pseudo-dimer that specifically recognize a bipartite element located in this RNA sequence.
MYC (c-MYC) and Beta-TRCP1 mRNAs are bound at sites termed Coding Region Determinants (CDRs) in the open reading frame of the message. Binding of the MYC mRNA shields it from degradation and increases its half-life
The CD44 mRNA is bound at the 3' UTR.
IGF2BP1 also binds the non-coding, imprinted H19 RNA.

Edited: May, B, 2009-07-04

Authored: May, B, 2009-07-04

Reviewed: Singer, RH, 2010-05-30

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http://purl.obolibrary.org/obo/UniProt_Q9NZI8

http://purl.obolibrary.org/obo/HINO_0025379

http://purl.obolibrary.org/obo/HINO_0017487

IGF2BP1 Binds Specific RNA Molecules

HINO:0008761

IGF2BP1 Binds Specific RNA Molecules

ReactomeREACT_22241

Reactome Database ID Release 43428296

http://purl.obolibrary.org/obo/INO_0000040