loading...| Preferred Name |
Octanoylation of Proghrelin by Ghrelin O-acyltransferase |
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| Definitions |
Proghrelin is octanoylated by ghrelin O-acyltransferase (GOAT/MBOAT4), an enzyme present in the endoplasmic reticulum membrane which both transports the octanoic acid substrate and condenses it on the hydroxyl group of serine-3 of the mature protein. The most common acylated form of ghrelin is octanoyl ghrelin but decanoyl ghrelin is also detected. Ghrelin is the only protein known to undergo such a modification. Edited: May, B, 2009-06-10 Reviewed: Zhang, Weizhen, 2009-08-29 Authored: May, B, 2009-06-10 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0008758 |
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| comment |
Proghrelin is octanoylated by ghrelin O-acyltransferase (GOAT/MBOAT4), an enzyme present in the endoplasmic reticulum membrane which both transports the octanoic acid substrate and condenses it on the hydroxyl group of serine-3 of the mature protein. The most common acylated form of ghrelin is octanoyl ghrelin but decanoyl ghrelin is also detected. Ghrelin is the only protein known to undergo such a modification. Edited: May, B, 2009-06-10 Reviewed: Zhang, Weizhen, 2009-08-29 Authored: May, B, 2009-06-10 |
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| definition source |
Pubmed19628676 Reactome, http://www.reactome.org Pubmed19280057 Pubmed12414809 Pubmed18443287 Pubmed18396350 |
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| label |
Octanoylation of Proghrelin by Ghrelin O-acyltransferase |
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| prefixIRI |
HINO:0008758 |
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| prefLabel |
Octanoylation of Proghrelin by Ghrelin O-acyltransferase |
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| seeAlso |
Reactome Database ID Release 43422104 ReactomeREACT_19318 |
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