loading...| Preferred Name |
phenylalanine + oxaloacetate => phenylpyruvate + aspartate [CCBL1] |
|
| Synonyms |
|
|
| Definitions |
Edited: D'Eustachio, P, 2012-03-16 Reviewed: Jassal, B, 2012-03-16 CCBL1 (KAT1) catalyzes the reaction of phenylalanine and oxaloacetate to form keto-phenylpyruvate and aspartate. The active form of CCBL1 is a homodimer with one molecule of pyridoxal phosphate bound to each monomer (Rossi et al. 2004). CCBL1 (KAT1) acts on phenylalanine and kynurenine with comparable efficiencies (Han et al. 2004), consistent with the idea that when phenylalanine levels are elevated CCBL1 (KAT1) activity could be a major source of phenylpyruvate. Oxaloacetate is one of several 2-oxoacids that function efficiently in CCBL1-mediated transamination (Han et al. 2004). Notably, neither tyrosine aminotransferase (Sivaraman and Kirsch 2006) nor glutamate-oxaloacetate aminotransferase (Cammarata and Cohen 1951) acts on phenylalanine. Authored: D'Eustachio, P, 2012-03-04 |
|
| ID |
http://purl.obolibrary.org/obo/HINO_0008199 |
|
| comment |
Edited: D'Eustachio, P, 2012-03-16 Reviewed: Jassal, B, 2012-03-16 CCBL1 (KAT1) catalyzes the reaction of phenylalanine and oxaloacetate to form keto-phenylpyruvate and aspartate. The active form of CCBL1 is a homodimer with one molecule of pyridoxal phosphate bound to each monomer (Rossi et al. 2004). CCBL1 (KAT1) acts on phenylalanine and kynurenine with comparable efficiencies (Han et al. 2004), consistent with the idea that when phenylalanine levels are elevated CCBL1 (KAT1) activity could be a major source of phenylpyruvate. Oxaloacetate is one of several 2-oxoacids that function efficiently in CCBL1-mediated transamination (Han et al. 2004). Notably, neither tyrosine aminotransferase (Sivaraman and Kirsch 2006) nor glutamate-oxaloacetate aminotransferase (Cammarata and Cohen 1951) acts on phenylalanine. Authored: D'Eustachio, P, 2012-03-04 |
|
| definition source |
Pubmed15364907 Reactome, http://www.reactome.org Pubmed15606768 Pubmed14907689 Pubmed16640556 |
|
| has input | ||
| has output | ||
| label |
phenylalanine + oxaloacetate => phenylpyruvate + aspartate [CCBL1] |
|
| prefixIRI |
HINO:0008199 |
|
| prefLabel |
phenylalanine + oxaloacetate => phenylpyruvate + aspartate [CCBL1] |
|
| seeAlso |
ReactomeREACT_121130 Reactome Database ID Release 432160461 |
|
| subClassOf |