loading...| Preferred Name |
dITP + H2O => dIMP + PPi |
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| Definitions |
Reviewed: Ito, Riyoko, 2012-10-05 Authored: D'Eustachio, P, 2012-10-05 Edited: D'Eustachio, P, 2012-10-05 Cytosolic ITPA dimer catalyzes the reaction of dITP and water to form dIMP and PPi (pyrophosphate). Mg++ is required for enzymatic activity. The hydrolysis of dITP is thought to prevent its incorporation into DNA, which would be mutagenic (Lin et al. 2001; Abolhassani et al. 2010). |
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| ID |
http://purl.obolibrary.org/obo/HINO_0003555 |
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| comment |
Reviewed: Ito, Riyoko, 2012-10-05 Authored: D'Eustachio, P, 2012-10-05 Edited: D'Eustachio, P, 2012-10-05 Cytosolic ITPA dimer catalyzes the reaction of dITP and water to form dIMP and PPi (pyrophosphate). Mg++ is required for enzymatic activity. The hydrolysis of dITP is thought to prevent its incorporation into DNA, which would be mutagenic (Lin et al. 2001; Abolhassani et al. 2010). |
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| definition source |
Pubmed20081199 Reactome, http://www.reactome.org Pubmed11278832 |
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| has input | ||
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| label |
dITP + H2O => dIMP + PPi |
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| name |
ITPA hydrolyses dITP to dIMP |
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| prefixIRI |
HINO:0003555 |
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| prefLabel |
dITP + H2O => dIMP + PPi |
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| seeAlso |
ReactomeREACT_150247 Reactome Database ID Release 432509838 |
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