loading...| Preferred Name |
hepatic stellate cell |
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| Synonyms |
perisinusoidal cell hepatic perisinusoidal cell Ito cell vitamin A-storing cells fat-storing cell lipocyte |
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| Definitions |
Hepatic stellate cells are CD271-positive, desmin-positive, DDR-2-positive, GFAP-positive, synamin-positive, synaptophysin-positive, vimentin-positive, They are capable of producing angiotensin II, fibronectin, laminin, MMP-1, MMP-2, MMP-3, MMP-9, MMP-11, TGF-beta1, TIMP-1, TIMP-2, type I collagen, type III collagen, type IV collagen, and type VI collagen. A cell that is found in the perisinusoidal space of the liver that is capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components that can contribute to liver fibrosis. This activated state has a myofibroblast-like phenotype, though it's not clear in the literature if this is terminally differentiated. This cell type comprises approximately 8-15% of total cells in the liver. |
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| ID |
http://purl.obolibrary.org/obo/CL_0000632 |
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| comment |
Hepatic stellate cells are CD271-positive, desmin-positive, DDR-2-positive, GFAP-positive, synamin-positive, synaptophysin-positive, vimentin-positive, They are capable of producing angiotensin II, fibronectin, laminin, MMP-1, MMP-2, MMP-3, MMP-9, MMP-11, TGF-beta1, TIMP-1, TIMP-2, type I collagen, type III collagen, type IV collagen, and type VI collagen. |
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| database_cross_reference |
BTO:0002741 CALOHA:TS-0452 FMA:67763 |
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| has exact synonym |
perisinusoidal cell hepatic perisinusoidal cell Ito cell |
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| has plasma membrane part | ||
| has_related_synonym |
vitamin A-storing cells fat-storing cell lipocyte |
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| in_subset |
http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas |
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| label |
hepatic stellate cell |
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| part_of | ||
| prefixIRI |
CL:0000632 |
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| prefLabel |
hepatic stellate cell |
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| present_in_taxon | ||
| textual definition |
A cell that is found in the perisinusoidal space of the liver that is capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components that can contribute to liver fibrosis. This activated state has a myofibroblast-like phenotype, though it's not clear in the literature if this is terminally differentiated. This cell type comprises approximately 8-15% of total cells in the liver. |
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| treeView | ||
| subClassOf |
http://purl.obolibrary.org/obo/CL_0000057 http://purl.obolibrary.org/obo/CL_0000327 |