loading...| Preferred Name |
finasteride |
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| Synonyms |
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| Definitions |
A synthetic 4-azasteroid compound. Finasteride competitively binds to and inhibits steroid type II 5-alpha-reductase in the prostate gland, liver, and skin, thereby interfering with the enzymatic conversion of testosterone to 5-dihydrotestosterone (DHT) and reducing serum DHT levels. The reduction in serum DHT levels results in diminished stimulation of androgen receptors in the nuclei of prostate cells and, so, diminished prostate cell proliferation. |
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| ID |
http://purl.obolibrary.org/obo/CHEBI_5062 |
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| ATC Code |
D11AX10 G04CB01 |
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| ChEBI ID | ||
| definition |
A synthetic 4-azasteroid compound. Finasteride competitively binds to and inhibits steroid type II 5-alpha-reductase in the prostate gland, liver, and skin, thereby interfering with the enzymatic conversion of testosterone to 5-dihydrotestosterone (DHT) and reducing serum DHT levels. The reduction in serum DHT levels results in diminished stimulation of androgen receptors in the nuclei of prostate cells and, so, diminished prostate cell proliferation. An orally active 3-oxo-5-alpha-steroid 4-dehydrogenase inhibitor. It is used as a surgical alternative for treatment of benign prostatic hyperplasia. A medication used mainly to treat an enlarged prostate or hair loss in men. It can also be used to treat excessive hair growth in women and as a part of hormone therapy for transgender women. An aza-steroid that is a synthetic drug for the treatment of benign prostatic hyperplasia. |
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| has database cross reference | ||
| label |
finasteride |
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| MeSH Descriptor ID | ||
| NCI Thesaurus ID | ||
| prefixIRI |
CHEBI:5062 |
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| prefLabel |
finasteride |
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| RxNorm ID | ||
| SNOMED CT Identifier | ||
| subClassOf |
http://purl.obolibrary.org/obo/CHEBI_35726 |