loading...| Preferred Name |
D-cycloserine |
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| Synonyms |
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| Definitions |
A 4-amino-1,2-oxazolidin-3-one that has R configuration. It is an antibiotic produced by Streptomyces garyphalus or S. orchidaceus and is used as part of a multi-drug regimen for the treatment of tuberculosis when resistance to, or toxicity from, primary drugs has developed. An analogue of D-alanine, it interferes with bacterial cell wall synthesis in the cytoplasm by competitive inhibition of L-alanine racemase (which forms D-alanine from L-alanine) and D-alanine--D-alanine ligase (which incorporates D-alanine into the pentapeptide required for peptidoglycan formation and bacterial cell wall synthesis). |
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| ID |
http://purl.obolibrary.org/obo/CHEBI_40009 |
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| alternative label |
CYC Cs |
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| has_alternative_id |
CHEBI:4030 |
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| imported from | ||
| label |
D-cycloserine |
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| prefixIRI |
CHEBI:40009 |
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| prefLabel |
D-cycloserine |
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| textual definition |
A 4-amino-1,2-oxazolidin-3-one that has R configuration. It is an antibiotic produced by Streptomyces garyphalus or S. orchidaceus and is used as part of a multi-drug regimen for the treatment of tuberculosis when resistance to, or toxicity from, primary drugs has developed. An analogue of D-alanine, it interferes with bacterial cell wall synthesis in the cytoplasm by competitive inhibition of L-alanine racemase (which forms D-alanine from L-alanine) and D-alanine--D-alanine ligase (which incorporates D-alanine into the pentapeptide required for peptidoglycan formation and bacterial cell wall synthesis). |
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| subClassOf |
http://purl.obolibrary.org/obo/CHEBI_25807 http://purl.obolibrary.org/obo/CHEBI_25558 |