loading...| Preferred Name |
nimodipine |
|
| Synonyms |
Nimodipine 2-methoxyethyl propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate nimodipinum 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-beta-methoxyethyl ester 5-isopropyl ester BAY e 9736 isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate nimodipine nimodipino Periplum Nimotop |
|
| Definitions |
A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm. |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_7575 |
|
| charge |
0 |
|
| database_cross_reference |
KEGG DRUG:D00438 ChEMBL:465248 CiteXplore:17110283 KEGG COMPOUND:C07267 CiteXplore:8519001 CiteXplore:21869451 SNOMEDCT:87285001 CiteXplore:12137606 MeSH:D009553 Reaxys:459792 KEGG COMPOUND:66085-59-4 ChemIDplus:66085-59-4 CiteXplore:22300914 CiteXplore:22262041 NIST Chemistry WebBook:66085-59-4 SNOMEDCT:387502003 CiteXplore:16180362 NCIt:C692 LINCS:LSM-1659 PMID:8519001 PMID:22262041 PMID:17110283 KEGG:C07267 DrugBank:DB00393 Patent:US3799934 KEGG:D00438 Patent:DE2117571 PMID:21869451 Drug_Central:1937 PMID:22300914 CAS:66085-59-4 PMID:12137606 PMID:16180362 Wikipedia:Nimodipine |
|
| definition |
A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm. |
|
| formula |
C21H26N2O7 |
|
| has_exact_synonym |
Nimodipine 2-methoxyethyl propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate |
|
| has_obo_namespace |
chebi_ontology |
|
| has_related_synonym |
nimodipinum 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-beta-methoxyethyl ester 5-isopropyl ester BAY e 9736 isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate nimodipine nimodipino Periplum Nimotop |
|
| has_role | ||
| id |
CHEBI:7575 |
|
| in_subset | ||
| inchi |
InChI=1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3 |
|
| inchikey |
UIAGMCDKSXEBJQ-UHFFFAOYSA-N |
|
| label |
nimodipine |
|
| mass |
418.44030 |
|
| monoisotopicmass |
418.17400 |
|
| notation |
CHEBI:7575 |
|
| prefLabel |
nimodipine |
|
| smiles |
COCCOC(=O)C1=C(C)NC(C)=C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OC(C)C |
|
| subClassOf |