The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Preferred Name

miglitol

Synonyms

(2R,3R,4R,5S)-1-(2-hydroxyethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol

C8H17NO5

ID

http://purl.obolibrary.org/obo/dinto_DB00491

ATCCode

A10BF02

blocks

http://purl.obolibrary.org/obo/dinto_4315

http://purl.obolibrary.org/obo/dinto_2209

http://purl.obolibrary.org/obo/dinto_1687

http://purl.obolibrary.org/obo/dinto_1709

CASRN

72432-03-2

DBBrand

glyset

Definition

Miglitol is an oral anti-diabetic drug that acts by inhibiting the ability of the patient to breakdown complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the body. Miglitol inhibits glycoside hydrolase enzymes called alpha-glucosidases. Since miglitol works by preventing digestion of carbohydrates, it lowers the degree of postprandial hyperglycemia. It must be taken at the start of main meals to have maximal effect. Its effect will depend on the amount of non-monosaccharide carbohydrates in a person s diet. In contrast to acarbose (another alpha-glucosidase inhibitor), miglitol is systemically absorbed; however, it is not metabolized and is excreted by the kidneys.

has effect

http://purl.obolibrary.org/obo/OAE_0000374

http://purl.obolibrary.org/obo/OAE_0000402

http://purl.obolibrary.org/obo/OAE_0000536

http://purl.obolibrary.org/obo/OAE_0000362

has pharmacological target

http://purl.obolibrary.org/obo/dinto_4315

http://purl.obolibrary.org/obo/dinto_2209

http://purl.obolibrary.org/obo/dinto_1687

http://purl.obolibrary.org/obo/dinto_1709

InChI

InChI=1S/C8H17NO5/c10-2-1-9-3-6(12)8(14)7(13)5(9)4-11/h5-8,10-14H,1-4H2/t5-,6+,7-,8-/m1/s1

InChIKey

InChIKey=IBAQFPQHRJAVAV-ULAWRXDQSA-N

inhibits

http://purl.obolibrary.org/obo/dinto_2209

label

miglitol

may interact with

http://purl.obolibrary.org/obo/dinto_DB01296

http://purl.obolibrary.org/obo/dinto_DB00052

prefixIRI

obo2:dinto_DB00491

prefLabel

miglitol

related with

http://purl.obolibrary.org/obo/dinto_0900

SMILES

OCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO

Synonym

(2R,3R,4R,5S)-1-(2-hydroxyethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol

C8H17NO5

xref

RxList:http://www.rxlist.com/cgi/generic2/miglitol.htm

PubChem Substance:46504492

Wikipedia:http://en.wikipedia.org/wiki/Miglitol

National Drug Code Directory:0009-5012-01

Drugs.com:http://www.drugs.com/cdi/miglitol.html

ChemSpider:390074

PharmGKB:PA164776726

PubChem Compound:441314

subClassOf

http://purl.obolibrary.org/obo/dinto_000055

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http://mimi.case.edu/ontologies/2009/9/DrugOntology#miglitol SDO LOOM
http://purl.bioontology.org/ontology/MESH/C045621 MESH LOOM
http://www.drugbank.ca/drugs/DB00491 FTC LOOM
http://purl.jp/bio/4/id/200906081347613823 IOBC LOOM
http://purl.bioontology.org/ontology/RXNORM/30009 RXNORM LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/109071007 SNOMEDCT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C045621 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386046009 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/CHEBI_6935 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_6935 NBO LOOM
http://purl.bioontology.org/ontology/UATC/A10BF02 ATC LOOM
http://purl.bioontology.org/ontology/VANDF/4021063 VANDF LOOM
https://bioportal.bioontology.org/ontologies/DMTO.owl#DMTO_0000922 DMTO LOOM
http://purl.obolibrary.org/obo/DRON_00011113 DRON LOOM
http://purl.obolibrary.org/obo/DRON_00011113 DRON LOOM
https://bioportal.bioontology.org/ontologies/FTDM.owl#DMTO_0000922 FASTO LOOM
https://bioportal.bioontology.org/ontologies/DMTO.owl#DMTO_0001537 DMTO LOOM
https://bioportal.bioontology.org/ontologies/FTDM.owl#DMTO_0001537 FASTO LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61847 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61847 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61847 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61847 NCIT LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148526 NDFRT LOOM