The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

Details
Visualization
Notes ( 0 )
Class Mappings ( )

Preferred Name	grepafloxacin
Synonyms	C19H22FN3O3 1-cyclopropyl-6-fluoro-5-methyl-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
ID	http://purl.obolibrary.org/obo/dinto_DB00365
ATCCode	J01MA11
CASRN	119914-60-2
DBBrand	raxar
Definition	Grepafloxacin hydrochloride (Raxar and reg;, Glaxo Wellcome) is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Grepafloxacin was withdrawn in the United States due to its side effect of lengthening the QT interval on the electrocardiogram, leading to cardiac events and sudden death. [Wikipedia]
has pharmacological target	http://purl.obolibrary.org/obo/dinto_0551 http://purl.obolibrary.org/obo/dinto_1028
InChI	InChI=1S/C19H22FN3O3/c1-10-8-22(6-5-21-10)15-7-14-16(11(2)17(15)20)18(24)13(19(25)26)9-23(14)12-3-4-12/h7,9-10,12,21H,3-6,8H2,1-2H3,(H,25,26)
InChIKey	InChIKey=AIJTTZAVMXIJGM-UHFFFAOYSA-N
inhibits	http://purl.obolibrary.org/obo/dinto_0551 http://purl.obolibrary.org/obo/dinto_1979 http://purl.obolibrary.org/obo/dinto_0887 http://purl.obolibrary.org/obo/dinto_1440 http://purl.obolibrary.org/obo/dinto_2789 http://purl.obolibrary.org/obo/dinto_1028
is metabolised by	http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_0901
is transported by	http://purl.obolibrary.org/obo/dinto_1440 http://purl.obolibrary.org/obo/dinto_2828 http://purl.obolibrary.org/obo/dinto_0520
label	grepafloxacin
may interact with	http://purl.obolibrary.org/obo/dinto_DB01303 http://purl.obolibrary.org/obo/dinto_DB01142 http://purl.obolibrary.org/obo/CHEBI_6838 http://purl.obolibrary.org/obo/CHEBI_8028 http://purl.obolibrary.org/obo/CHEBI_3647 http://purl.obolibrary.org/obo/CHEBI_8491 http://purl.obolibrary.org/obo/dinto_DB00344 http://purl.obolibrary.org/obo/CHEBI_9711 http://purl.obolibrary.org/obo/dinto_DB00540 http://purl.obolibrary.org/obo/dinto_DB01223 http://purl.obolibrary.org/obo/CHEBI_45951 http://purl.obolibrary.org/obo/CHEBI_47499 http://purl.obolibrary.org/obo/dinto_DB00726 http://purl.obolibrary.org/obo/dinto_DB00893 http://purl.obolibrary.org/obo/CHEBI_47780 http://purl.obolibrary.org/obo/CHEBI_63622 http://purl.obolibrary.org/obo/dinto_DB00342 http://purl.obolibrary.org/obo/CHEBI_3172 http://purl.obolibrary.org/obo/CHEBI_6780 http://purl.obolibrary.org/obo/dinto_DB01370 http://purl.obolibrary.org/obo/CHEBI_9566 http://purl.obolibrary.org/obo/CHEBI_31794 http://purl.obolibrary.org/obo/dinto_DB00364 http://purl.obolibrary.org/obo/CHEBI_8459 http://purl.obolibrary.org/obo/CHEBI_5123 http://purl.obolibrary.org/obo/CHEBI_27732 http://purl.obolibrary.org/obo/dinto_DB01593 http://purl.obolibrary.org/obo/CHEBI_4728 http://purl.obolibrary.org/obo/CHEBI_8461 http://purl.obolibrary.org/obo/CHEBI_8435 http://purl.obolibrary.org/obo/dinto_DB01378 http://purl.obolibrary.org/obo/CHEBI_28593 http://purl.obolibrary.org/obo/dinto_DB01118 http://purl.obolibrary.org/obo/dinto_DB00199 http://purl.obolibrary.org/obo/dinto_DB01369 http://purl.obolibrary.org/obo/CHEBI_31739 http://purl.obolibrary.org/obo/dinto_DB01373 http://purl.obolibrary.org/obo/CHEBI_9544 http://purl.obolibrary.org/obo/CHEBI_3061 http://purl.obolibrary.org/obo/CHEBI_4657 http://purl.obolibrary.org/obo/CHEBI_2896 http://purl.obolibrary.org/obo/CHEBI_28177 http://purl.obolibrary.org/obo/dinto_DB01592 http://purl.obolibrary.org/obo/CHEBI_47781 http://purl.obolibrary.org/obo/dinto_DB01346 http://purl.obolibrary.org/obo/dinto_DB06210 http://purl.obolibrary.org/obo/dinto_DB01341 http://purl.obolibrary.org/obo/CHEBI_2675 http://purl.obolibrary.org/obo/CHEBI_2666
prefixIRI	obo2:dinto_DB00365
prefLabel	grepafloxacin
SMILES	CC1CN(CCN1)C1=C(F)C(C)=C2C(=O)C(=CN(C3CC3)C2=C1)C(O)=O
Synonym	C19H22FN3O3 1-cyclopropyl-6-fluoro-5-methyl-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
xref	RxList:http://www.rxlist.com/cgi/generic2/grepa.htm ChemSpider:65391 BindingDB:50117924 Drugs Product Database (DPD):2237735 PharmGKB:PA449812 PubChem Compound:72474 Wikipedia:http://en.wikipedia.org/wiki/Grepafloxacin PubChem Substance:46507253 Drugs.com:http://www.drugs.com/mtm/grepafloxacin.html
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

Add comment

Add proposal

Subscribe to notes emails

Delete	Subject	Author	Type	Created
No notes to display

Create mapping

Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/ARO_3000665	ARO	LOOM
http://purl.bioontology.org/ontology/LNC/LP19489-1	LOINC	LOOM
http://purl.bioontology.org/ontology/VANDF/4024097	VANDF	LOOM
http://purl.jp/bio/4/id/200906044042057030	IOBC	LOOM
http://purl.bioontology.org/ontology/MESH/C075375	MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C075375	RH-MESH	LOOM
http://purl.obolibrary.org/obo/CHEBI_5543	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_5543	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_5543	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_5543	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_5543	GENEPIO	LOOM
http://purl.bioontology.org/ontology/RXNORM/83719	RXNORM	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C65817	NCIT	LOOM
http://purl.bioontology.org/ontology/ATC/J01MA11	ATC	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386892006	SNOMEDCT	LOOM
http://www.co-ode.org/ontologies/galen#Grepafloxacin	GALEN	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000022102	NDFRT	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00026064	PMAPP-PMO	LOOM
http://purl.bioontology.org/ontology/NDDF/007022	NDDF	LOOM
http://stirdf.jst.go.jp/id/200907096717096581	IOBC	LOOM
https://go.drugbank.com/drugs/DB00365	MDM	LOOM
http://purl.obolibrary.org/obo/NCIT_C65817	BERO	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU009696	LOINC	LOOM