The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Preferred Name

tramadol

Synonyms

(+-)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol

rac-(1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol

U-26225A

CG-315E

tramadol

(1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexan-1-ol

tramadolum

E-265

C16H25NO2

ID

http://purl.obolibrary.org/obo/CHEBI_9648

activates

http://purl.obolibrary.org/obo/dinto_3960

http://purl.obolibrary.org/obo/dinto_0760

http://purl.obolibrary.org/obo/dinto_2787

AHFScode

28:08.08

ATCCode

N02AX02

blocks

http://purl.obolibrary.org/obo/dinto_2150

http://purl.obolibrary.org/obo/dinto_3364

http://purl.obolibrary.org/obo/dinto_1005

http://purl.obolibrary.org/obo/dinto_0510

CASRN

27203-92-5

DBBrand

ralivia er

ultram er

rybix

ralivia flashtab

tramadol hcl bp/ep

tridural

crispin

conzip

durela

ultram

tramal

zytram xl

DBname

tramadol

DBSalt

tramadol hydrochloride

Definition

A racemate consisting of equal amounts of (R,R)- and (S,S)-tramadol. A centrally acting synthetic opioid analgesic, used (as the hydrochloride salt) to treat moderately severe pain. The (R,R)-enantiomer exhibits ten-fold higher analgesic potency than the (S,S)-enantiomer. Subsequently isolated from the root bark of Nauclea latifolia

has effect

http://purl.obolibrary.org/obo/OAE_0000426

http://purl.obolibrary.org/obo/OAE_0000100

http://purl.obolibrary.org/obo/OAE_0000599

http://purl.obolibrary.org/obo/OAE_0000081

http://purl.obolibrary.org/obo/OAE_0001044

http://purl.obolibrary.org/obo/OAE_0000505

http://purl.obolibrary.org/obo/OAE_0000355

http://purl.obolibrary.org/obo/OAE_0000573

http://purl.obolibrary.org/obo/OAE_0000411

http://purl.obolibrary.org/obo/OAE_0000400

http://purl.obolibrary.org/obo/OAE_0000770

http://purl.obolibrary.org/obo/OAE_0000421

http://purl.obolibrary.org/obo/OAE_0000356

http://purl.obolibrary.org/obo/OAE_0000727

http://purl.obolibrary.org/obo/OAE_0000390

http://purl.obolibrary.org/obo/OAE_0000401

http://purl.obolibrary.org/obo/OAE_0000412

http://purl.obolibrary.org/obo/OAE_0000185

http://purl.obolibrary.org/obo/OAE_0000377

http://purl.obolibrary.org/obo/OAE_0001345

http://purl.obolibrary.org/obo/OAE_0000632

http://purl.obolibrary.org/obo/OAE_0000968

http://purl.obolibrary.org/obo/OAE_0001205

http://purl.obolibrary.org/obo/OAE_0000608

http://purl.obolibrary.org/obo/OAE_0000567

http://purl.obolibrary.org/obo/OAE_0000842

http://purl.obolibrary.org/obo/OAE_0000218

http://purl.obolibrary.org/obo/OAE_0001509

http://purl.obolibrary.org/obo/OAE_0001105

http://purl.obolibrary.org/obo/OAE_0000462

http://purl.obolibrary.org/obo/OAE_0000473

http://purl.obolibrary.org/obo/OAE_0001001

http://purl.obolibrary.org/obo/OAE_0000496

http://purl.obolibrary.org/obo/OAE_0000888

http://purl.obolibrary.org/obo/OAE_0001461

http://purl.obolibrary.org/obo/OAE_0001403

http://purl.obolibrary.org/obo/OAE_0000659

http://purl.obolibrary.org/obo/OAE_0000495

http://purl.obolibrary.org/obo/OAE_0000344

http://purl.obolibrary.org/obo/OAE_0000333

http://purl.obolibrary.org/obo/OAE_0000391

http://purl.obolibrary.org/obo/OAE_0001448

http://purl.obolibrary.org/obo/OAE_0000898

http://purl.obolibrary.org/obo/OAE_0000281

http://purl.obolibrary.org/obo/OAE_0001025

http://purl.obolibrary.org/obo/OAE_0000335

http://purl.obolibrary.org/obo/OAE_0000300

http://purl.obolibrary.org/obo/OAE_0001046

http://purl.obolibrary.org/obo/OAE_0000716

http://purl.obolibrary.org/obo/OAE_0001280

http://purl.obolibrary.org/obo/OAE_0000600

http://purl.obolibrary.org/obo/OAE_0000611

http://purl.obolibrary.org/obo/OAE_0000902

http://purl.obolibrary.org/obo/OAE_0000533

http://purl.obolibrary.org/obo/OAE_0000242

http://purl.obolibrary.org/obo/OAE_0001052

http://purl.obolibrary.org/obo/OAE_0000545

http://purl.obolibrary.org/obo/OAE_0000385

http://purl.obolibrary.org/obo/OAE_0001489

http://purl.obolibrary.org/obo/OAE_0000198

http://purl.obolibrary.org/obo/OAE_0000557

http://purl.obolibrary.org/obo/OAE_0000406

http://purl.obolibrary.org/obo/OAE_0000050

http://purl.obolibrary.org/obo/OAE_0000789

http://purl.obolibrary.org/obo/OAE_0001164

http://purl.obolibrary.org/obo/OAE_0001013

http://purl.obolibrary.org/obo/OAE_0000301

http://purl.obolibrary.org/obo/OAE_0000650

http://purl.obolibrary.org/obo/OAE_0001405

http://purl.obolibrary.org/obo/OAE_0000396

http://purl.obolibrary.org/obo/OAE_0001340

http://purl.obolibrary.org/obo/OAE_0001003

http://purl.obolibrary.org/obo/OAE_0000604

http://purl.obolibrary.org/obo/OAE_0001755

http://purl.obolibrary.org/obo/OAE_0001373

http://purl.obolibrary.org/obo/OAE_0001200

http://purl.obolibrary.org/obo/OAE_0000246

http://purl.obolibrary.org/obo/OAE_0000596

http://purl.obolibrary.org/obo/OAE_0000491

http://purl.obolibrary.org/obo/OAE_0000502

http://purl.obolibrary.org/obo/OAE_0001457

http://purl.obolibrary.org/obo/OAE_0000513

http://purl.obolibrary.org/obo/OAE_0000883

http://purl.obolibrary.org/obo/OAE_0000894

http://purl.obolibrary.org/obo/OAE_0001169

http://purl.obolibrary.org/obo/OAE_0000501

http://purl.obolibrary.org/obo/OAE_0000512

http://purl.obolibrary.org/obo/OAE_0000329

http://purl.obolibrary.org/obo/OAE_0001053

http://purl.obolibrary.org/obo/OAE_0001098

http://purl.obolibrary.org/obo/OAE_0001063

http://purl.obolibrary.org/obo/OAE_0000317

http://purl.obolibrary.org/obo/OAE_0000375

http://purl.obolibrary.org/obo/OAE_0000353

http://purl.obolibrary.org/obo/OAE_0000306

http://purl.obolibrary.org/obo/OAE_0000479

http://purl.obolibrary.org/obo/OAE_0000630

http://purl.obolibrary.org/obo/OAE_0000250

http://purl.obolibrary.org/obo/OAE_0000606

http://purl.obolibrary.org/obo/OAE_0001744

http://purl.obolibrary.org/obo/OAE_0001285

http://purl.obolibrary.org/obo/OAE_0002206

http://purl.obolibrary.org/obo/OAE_0000586

http://purl.obolibrary.org/obo/OAE_0000517

http://purl.obolibrary.org/obo/OAE_0000919

http://purl.obolibrary.org/obo/OAE_0000470

http://purl.obolibrary.org/obo/OAE_0001505

http://purl.obolibrary.org/obo/OAE_0000839

http://purl.obolibrary.org/obo/OAE_0000022

http://purl.obolibrary.org/obo/OAE_0000482

http://purl.obolibrary.org/obo/OAE_0000493

http://purl.obolibrary.org/obo/OAE_0000424

http://purl.obolibrary.org/obo/OAE_0000885

http://purl.obolibrary.org/obo/OAE_0000861

http://purl.obolibrary.org/obo/OAE_0001147

http://purl.obolibrary.org/obo/OAE_0000597

http://purl.obolibrary.org/obo/OAE_0000492

http://purl.obolibrary.org/obo/OAE_0000365

http://purl.obolibrary.org/obo/OAE_0000469

http://purl.obolibrary.org/obo/OAE_0000343

http://purl.obolibrary.org/obo/OAE_0000447

http://purl.obolibrary.org/obo/OAE_0001393

http://purl.obolibrary.org/obo/OAE_0000308

http://purl.obolibrary.org/obo/OAE_0000319

http://purl.obolibrary.org/obo/OAE_0000691

http://purl.obolibrary.org/obo/OAE_0001369

http://purl.obolibrary.org/obo/OAE_0000376

http://purl.obolibrary.org/obo/OAE_0000299

http://purl.obolibrary.org/obo/OAE_0000922

http://purl.obolibrary.org/obo/OAE_0000194

http://purl.obolibrary.org/obo/OAE_0000084

http://purl.obolibrary.org/obo/OAE_0001463

http://purl.obolibrary.org/obo/OAE_0000487

http://purl.obolibrary.org/obo/OAE_0000103

http://purl.obolibrary.org/obo/OAE_0000542

http://purl.obolibrary.org/obo/OAE_0000945

http://purl.obolibrary.org/obo/OAE_0000497

http://purl.obolibrary.org/obo/OAE_0000508

http://purl.obolibrary.org/obo/OAE_0000195

http://purl.obolibrary.org/obo/OAE_0000921

http://purl.obolibrary.org/obo/OAE_0000382

http://purl.obolibrary.org/obo/OAE_0000403

http://purl.obolibrary.org/obo/OAE_0000414

http://purl.obolibrary.org/obo/OAE_0000518

http://purl.obolibrary.org/obo/OAE_0000358

http://purl.obolibrary.org/obo/OAE_0000762

http://purl.obolibrary.org/obo/OAE_0000460

http://purl.obolibrary.org/obo/OAE_0000402

http://purl.obolibrary.org/obo/OAE_0000034

http://purl.obolibrary.org/obo/OAE_0001751

http://purl.obolibrary.org/obo/OAE_0000021

http://purl.obolibrary.org/obo/OAE_0001360

http://purl.obolibrary.org/obo/OAE_0000601

http://purl.obolibrary.org/obo/OAE_0000310

http://purl.obolibrary.org/obo/OAE_0000646

http://purl.obolibrary.org/obo/OAE_0000243

http://purl.obolibrary.org/obo/OAE_0000645

http://purl.obolibrary.org/obo/OAE_0001580

http://purl.obolibrary.org/obo/OAE_0000453

http://purl.obolibrary.org/obo/OAE_0000647

http://purl.obolibrary.org/obo/OAE_0000881

http://purl.obolibrary.org/obo/OAE_0001166

http://purl.obolibrary.org/obo/OAE_0000475

http://purl.obolibrary.org/obo/OAE_0001050

http://purl.obolibrary.org/obo/OAE_0000038

http://purl.obolibrary.org/obo/OAE_0001026

http://purl.obolibrary.org/obo/OAE_0000498

http://purl.obolibrary.org/obo/OAE_0000336

http://purl.obolibrary.org/obo/OAE_0000394

http://purl.obolibrary.org/obo/OAE_0000086

http://purl.obolibrary.org/obo/OAE_0000350

http://purl.obolibrary.org/obo/OAE_0001062

http://purl.obolibrary.org/obo/OAE_0000327

http://purl.obolibrary.org/obo/OAE_0000476

http://purl.obolibrary.org/obo/OAE_0000303

http://purl.obolibrary.org/obo/OAE_0000395

http://purl.obolibrary.org/obo/OAE_0000905

http://purl.obolibrary.org/obo/OAE_0000166

http://purl.obolibrary.org/obo/OAE_0000211

http://purl.obolibrary.org/obo/OAE_0001361

http://purl.obolibrary.org/obo/OAE_0000660

http://purl.obolibrary.org/obo/OAE_0000602

http://purl.obolibrary.org/obo/OAE_0000525

http://purl.obolibrary.org/obo/OAE_0000536

http://purl.obolibrary.org/obo/OAE_0000210

http://purl.obolibrary.org/obo/OAE_0000975

http://purl.obolibrary.org/obo/OAE_0001055

http://purl.obolibrary.org/obo/OAE_0000514

http://purl.obolibrary.org/obo/OAE_0001458

http://purl.obolibrary.org/obo/OAE_0000561

http://purl.obolibrary.org/obo/OAE_0000388

http://purl.obolibrary.org/obo/OAE_0000526

http://purl.obolibrary.org/obo/OAE_0000584

http://purl.obolibrary.org/obo/OAE_0000443

http://purl.obolibrary.org/obo/OAE_0002122

http://purl.obolibrary.org/obo/OAE_0000455

http://purl.obolibrary.org/obo/OAE_0000466

http://purl.obolibrary.org/obo/OAE_0000362

http://purl.obolibrary.org/obo/OAE_0000304

http://purl.obolibrary.org/obo/OAE_0000340

http://purl.obolibrary.org/obo/OAE_0001309

http://purl.obolibrary.org/obo/OAE_0001366

http://purl.obolibrary.org/obo/OAE_0000607

http://purl.obolibrary.org/obo/OAE_0000296

http://purl.obolibrary.org/obo/OAE_0000720

http://purl.obolibrary.org/obo/OAE_0001529

http://purl.obolibrary.org/obo/OAE_0000373

http://purl.obolibrary.org/obo/OAE_0001597

http://purl.obolibrary.org/obo/OAE_0000551

has pharmacological target

http://purl.obolibrary.org/obo/dinto_0068

http://purl.obolibrary.org/obo/dinto_2714

http://purl.obolibrary.org/obo/dinto_2787

has role

http://purl.obolibrary.org/obo/CHEBI_70774

http://purl.obolibrary.org/obo/CHEBI_48279

http://purl.obolibrary.org/obo/CHEBI_60797

http://purl.obolibrary.org/obo/CHEBI_50949

http://purl.obolibrary.org/obo/CHEBI_26619

http://purl.obolibrary.org/obo/CHEBI_51177

http://purl.obolibrary.org/obo/CHEBI_35640

http://purl.obolibrary.org/obo/CHEBI_55322

http://purl.obolibrary.org/obo/CHEBI_48876

http://purl.obolibrary.org/obo/CHEBI_64054

http://purl.obolibrary.org/obo/CHEBI_35482

http://purl.obolibrary.org/obo/CHEBI_48878

http://purl.obolibrary.org/obo/CHEBI_59282

InChI

InChI=1S/C16H25NO2/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3/t14-,16+/m1/s1

InChIKey

InChIKey=TVYLLZQTGLZFBW-ZBFHGGJFSA-N

inhibits

http://purl.obolibrary.org/obo/dinto_0068

http://purl.obolibrary.org/obo/dinto_0901

http://purl.obolibrary.org/obo/dinto_2993

http://purl.obolibrary.org/obo/dinto_2714

is metabolised by

http://purl.obolibrary.org/obo/dinto_0901

http://purl.obolibrary.org/obo/dinto_2993

http://purl.obolibrary.org/obo/dinto_0465

label

tramadol

prefixIRI

obo2:CHEBI_9648

prefLabel

tramadol

SMILES

COC1=CC=CC(=C1)[C@@]1(O)CCCC[C@@H]1CN(C)C

Synonym

(+-)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol

rac-(1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol

U-26225A

CG-315E

tramadol

(1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexan-1-ol

tramadolum

E-265

C16H25NO2

xref

CiteXplore:23102445

CiteXplore:23825758

BindingDB:50176262

CiteXplore:23962470

CiteXplore:23907474

HMDB:HMDB14339

ChemSpider:31105

CiteXplore:23292128

CASRN:27203-92-5

CiteXplore:23061925

CiteXplore:23755929

CiteXplore:23668411

PubChem Compound:33741

CiteXplore:23843224

Wikipedia:Tramadol

CiteXplore:23328338

CiteXplore:23543914

CiteXplore:23099620

Reaxys:2943832

Wikipedia:http://en.wikipedia.org/wiki/Tramadol

CiteXplore:22943675

CiteXplore:23098678

CiteXplore:23031839

CiteXplore:23840975

KEGG COMPOUND:C07153

CiteXplore:22674657

PubChem Substance:46506256

CiteXplore:23822079

CiteXplore:23145962

CiteXplore:23433451

RxList:http://www.rxlist.com/cgi/generic/tramadol.htm

CiteXplore:23095734

Patent:US3652589

DrugBank:DB00193

Patent:GB997399

National Drug Code Directory:0045-0659-60

KEGG DRUG:D08623

Drugs.com:http://www.drugs.com/tramadol.html

PharmGKB:PA451735

CiteXplore:22964800

CiteXplore:23872384

CiteXplore:23773348

CiteXplore:23756535

subClassOf

http://purl.obolibrary.org/obo/dinto_000055

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Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/NDFRT/N0000021990 NDFRT LOOM
http://purl.jp/bio/4/id/200906018832596810 IOBC LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Tramadol APAONTO LOOM
http://www.co-ode.org/ontologies/galen#Tramadol GALEN LOOM
http://purl.bioontology.org/ontology/RCD/dji.. RCD LOOM
http://purl.bioontology.org/ontology/RXNORM/10689 RXNORM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.092.668.387.750 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386858008 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/LNC/MTHU003394 LOINC LOOM
http://purl.bioontology.org/ontology/LNC/LP18112-0 LOINC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/108507005 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/DRON_00017838 DRON LOOM
http://purl.obolibrary.org/obo/DRON_00017838 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_9648 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_9648 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9648 NBO LOOM
http://purl.obolibrary.org/obo/CHEBI_9648 NBO SAME_URI
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29507 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29507 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29507 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29507 NCIT LOOM
http://bmi.utah.edu/ontologies/peontology/C0040610 RAO LOOM
http://purl.bioontology.org/ontology/CPT/80373 CPT LOOM
http://purl.bioontology.org/ontology/VANDF/4023985 VANDF LOOM
http://purl.bioontology.org/ontology/MESH/D014147 MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.033.480.300.802 RH-MESH LOOM
http://purl.bioontology.org/ontology/UATC/N02AX02 ATC LOOM
http://www.drugbank.ca/drugs/DB00193 FTC LOOM
http://www.limics.fr/ontologies/ontoparonmed#Tramadol ONTOPARON LOOM
http://www.limics.fr/ontologies/ontoparonmed#Tramadol ONTOPARON LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D014147 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDDF/004180 NDDF LOOM