The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	linezolid
Synonyms	C16H20FN3O4 N-{[(5S)-3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide N-(((S)-3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl)methyl)acetamide N-({(5S)-3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamide linezolid Linezolid
ID	http://purl.obolibrary.org/obo/CHEBI_63607
AHFScode	08:12.28.24
altId	CHEBI:6477
ATCCode	J01XX08
CASRN	165800-03-3
DBBrand	zyvox zyvoxid linezlid
DBname	linezolid
Definition	An organofluorine compound that consists of 1,3-oxazolidin-2-one bearing an N-3-fluoro-4-(morpholin-4-yl)phenyl group as well as an acetamidomethyl group at position 5. A synthetic antibacterial agent that inhibits bacterial protein synthesis by binding to a site on 23S ribosomal RNA of the 50S subunit and prevents further formation of a functional 70S initiation complex.
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000599 http://purl.obolibrary.org/obo/OAE_0000497 http://purl.obolibrary.org/obo/OAE_0000453 http://purl.obolibrary.org/obo/OAE_0001373 http://purl.obolibrary.org/obo/OAE_0000303 http://purl.obolibrary.org/obo/OAE_0000823 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000391 http://purl.obolibrary.org/obo/OAE_0000630 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000825 http://purl.obolibrary.org/obo/OAE_0001509 http://purl.obolibrary.org/obo/OAE_0000308 http://purl.obolibrary.org/obo/OAE_0001449 http://purl.obolibrary.org/obo/OAE_0000195 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000577 http://purl.obolibrary.org/obo/OAE_0000418 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0000317 http://purl.obolibrary.org/obo/OAE_0000382 http://purl.obolibrary.org/obo/OAE_0001073 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0000984 http://purl.obolibrary.org/obo/OAE_0000920 http://purl.obolibrary.org/obo/OAE_0000608 http://purl.obolibrary.org/obo/OAE_0000403 http://purl.obolibrary.org/obo/OAE_0000103 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0001463 http://purl.obolibrary.org/obo/OAE_0000691 http://purl.obolibrary.org/obo/OAE_0001275 http://purl.obolibrary.org/obo/OAE_0000517 http://purl.obolibrary.org/obo/OAE_0000455 http://purl.obolibrary.org/obo/OAE_0001057 http://purl.obolibrary.org/obo/OAE_0001243 http://purl.obolibrary.org/obo/OAE_0001425 http://purl.obolibrary.org/obo/OAE_0000286 http://purl.obolibrary.org/obo/OAE_0000086 http://purl.obolibrary.org/obo/OAE_0000645 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0001106 http://purl.obolibrary.org/obo/OAE_0000607 http://purl.obolibrary.org/obo/OAE_0000968 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0000460 http://purl.obolibrary.org/obo/OAE_0001499 http://purl.obolibrary.org/obo/OAE_0000780 http://purl.obolibrary.org/obo/OAE_0000343 http://purl.obolibrary.org/obo/OAE_0000536 http://purl.obolibrary.org/obo/OAE_0000505 http://purl.obolibrary.org/obo/OAE_0000306 http://purl.obolibrary.org/obo/OAE_0000194 http://purl.obolibrary.org/obo/OAE_0000468 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0000779 http://purl.obolibrary.org/obo/OAE_0001217 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0000881 http://purl.obolibrary.org/obo/OAE_0000394 http://purl.obolibrary.org/obo/OAE_0000358 http://purl.obolibrary.org/obo/OAE_0000618 http://purl.obolibrary.org/obo/OAE_0001364 http://purl.obolibrary.org/obo/OAE_0000402
has pharmacological target	http://purl.obolibrary.org/obo/dinto_2857
has role	http://purl.obolibrary.org/obo/CHEBI_48001 http://purl.obolibrary.org/obo/CHEBI_36047
InChI	InChI=1S/C16H20FN3O4/c1-11(21)18-9-13-10-20(16(22)24-13)12-2-3-15(14(17)8-12)19-4-6-23-7-5-19/h2-3,8,13H,4-7,9-10H2,1H3,(H,18,21)/t13-/m0/s1
InChIKey	InChIKey=TYZROVQLWOKYKF-ZDUSSCGKSA-N
inhibits	http://purl.obolibrary.org/obo/dinto_3613 http://purl.obolibrary.org/obo/dinto_2857 http://purl.obolibrary.org/obo/dinto_3622
label	linezolid
prefixIRI	obo2:CHEBI_63607
prefLabel	linezolid
SMILES	CC(=O)NC[C@H]1CN(C(=O)O1)C1=CC(F)=C(C=C1)N1CCOCC1 CC(=O)NC[C@H]1CN(C(=O)O1)c1ccc(N2CCOCC2)c(F)c1
Synonym	C16H20FN3O4 N-{[(5S)-3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide N-(((S)-3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl)methyl)acetamide N-({(5S)-3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamide linezolid Linezolid
xref	CiteXplore:22214776 CiteXplore:21815204 BindingDB:50116067 ChEMBL:126280 CiteXplore:21899392 CiteXplore:22064542 CiteXplore:22134348 Patent:WO957271 DrugBank:DB00601 Patent:US5688792 PubChem Substance:46504452 PDB:ZLD CiteXplore:22110086 ChemSpider:390139 KEGG COMPOUND:C08146 CiteXplore:22037854 CiteXplore:22064533 CASRN:165800-03-3 National Drug Code Directory:0009-5137-01 CiteXplore:22247123 KEGG DRUG:D00947 CiteXplore:22139199 PubChem Compound:441401 PDRhealth:http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/zyv1556.shtml PharmGKB:PA450233 CiteXplore:21740298 Reaxys:7496939 Wikipedia:Linezolid Drugs.com:http://www.drugs.com/cdi/linezolid.html CiteXplore:22230331 Drugs Product Database (DPD):2243684 Wikipedia:http://en.wikipedia.org/wiki/Linezolid RxList:http://www.rxlist.com/cgi/generic3/linezolid.htm
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_63607	PHIPO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_63607	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_63607	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_63607	FIDEO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_63607	COVID-19	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_63607	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_63607	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_63607	GENEPIO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_63607	PHIPO	LOOM
http://purl.obolibrary.org/obo/CHEBI_63607	CHEBI	LOOM
http://purl.bioontology.org/ontology/MESH/D000069349	MESH	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0663241	OCHV	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29158	NCIT	LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000735710	PDQ	LOOM
http://www.co-ode.org/ontologies/galen#Linezolid	GALEN	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C098010	RH-MESH	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148664	NDFRT	LOOM
http://purl.bioontology.org/ontology/VANDF/4021218	VANDF	LOOM
http://stirdf.jst.go.jp/id/200907010611791815	IOBC	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00015807	PMAPP-PMO	LOOM
https://go.drugbank.com/drugs/DB00601	MDM	LOOM
http://purl.bioontology.org/ontology/ATC/J01XX08	ATC	LOOM
http://purl.obolibrary.org/obo/OMIT_0001419	OMIT	LOOM
http://purl.obolibrary.org/obo/DRON_00013028	ODNAE	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148664	ODAE	LOOM
http://purl.obolibrary.org/obo/CHEBI_63607	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_63607	FIDEO	LOOM
http://purl.obolibrary.org/obo/CHEBI_63607	COVID-19	LOOM
http://purl.obolibrary.org/obo/CHEBI_63607	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_63607	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_63607	GENEPIO	LOOM
http://purl.obolibrary.org/obo/MESH_D000069349	BERO	LOOM
http://purl.jp/bio/4/id/200906035877363982	IOBC	LOOM
http://purl.obolibrary.org/obo/NCIT_C29158	BERO	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387056004	SNOMEDCT	LOOM
http://purl.bioontology.org/ontology/LNC/LP21256-0	LOINC	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU013614	LOINC	LOOM
http://purl.bioontology.org/ontology/RXNORM/190376	RXNORM	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#42522	OCHV	LOOM
http://purl.obolibrary.org/obo/ARO_0000072	ARO	LOOM