The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Jump to:
loading...
Preferred Name

roflumilast
Synonyms

C17H14Cl2F2N2O3

roflumilast

Daliresp

3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide

roflumilastum
ID

http://purl.obolibrary.org/obo/CHEBI_47657
AHFScode

48:32
ATCCode

R03DX07
binds

http://purl.obolibrary.org/obo/dinto_4063

http://purl.obolibrary.org/obo/dinto_3125

http://purl.obolibrary.org/obo/dinto_0074

http://purl.obolibrary.org/obo/dinto_2945
CASRN

162401-32-3
DBBrand

daliresp

daxas
DBSynonym

rof
Definition

Roflumilast is a phosphodiesterase-4 (PDE-4) inhibitor. Due to its selective inhibition of the PDE4 isoenzyme in lung cells, roflumilast is indicated for the management of chronic obstrtuctive pulmonary disease (COPD) exacerbations. Treatment with Roflumilast is associated with an increase in psychiatric adverse reactions, including suicide and suicidal attempts.

A benzamide obtained by formal condensation of the carboxy group of 3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid with the amino group of 3,5-dichloropyridin-4-amine. Used for treatment of bronchial asthma and chronic obstructive pulmonary disease.
has effect

http://purl.obolibrary.org/obo/OAE_0000388

http://purl.obolibrary.org/obo/OAE_0000453

http://purl.obolibrary.org/obo/OAE_0000377

http://purl.obolibrary.org/obo/OAE_0001327

http://purl.obolibrary.org/obo/OAE_0001273

http://purl.obolibrary.org/obo/OAE_0000839

http://purl.obolibrary.org/obo/OAE_0000659

http://purl.obolibrary.org/obo/OAE_0000567

http://purl.obolibrary.org/obo/OAE_0000195

http://purl.obolibrary.org/obo/OAE_0000319

http://purl.obolibrary.org/obo/OAE_0000600

http://purl.obolibrary.org/obo/OAE_0001365

http://purl.obolibrary.org/obo/OAE_0000601

http://purl.obolibrary.org/obo/OAE_0000300

http://purl.obolibrary.org/obo/OAE_0000455

http://purl.obolibrary.org/obo/OAE_0000498

http://purl.obolibrary.org/obo/OAE_0002206

http://purl.obolibrary.org/obo/OAE_0000414

http://purl.obolibrary.org/obo/OAE_0000968

http://purl.obolibrary.org/obo/OAE_0000166

http://purl.obolibrary.org/obo/OAE_0001205

http://purl.obolibrary.org/obo/OAE_0000374

http://purl.obolibrary.org/obo/OAE_0001364

http://purl.obolibrary.org/obo/OAE_0000402

http://purl.obolibrary.org/obo/OAE_0000350
has role

http://purl.obolibrary.org/obo/CHEBI_68844

http://purl.obolibrary.org/obo/CHEBI_49167
InChI

InChI=1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24)
InChIKey

InChIKey=MNDBXUUTURYVHR-UHFFFAOYSA-N
inhibits

http://purl.obolibrary.org/obo/dinto_4063

http://purl.obolibrary.org/obo/dinto_3125

http://purl.obolibrary.org/obo/dinto_0074

http://purl.obolibrary.org/obo/dinto_2945
label

roflumilast
may interact with

http://purl.obolibrary.org/obo/CHEBI_119486

http://purl.obolibrary.org/obo/CHEBI_41879

http://purl.obolibrary.org/obo/CHEBI_10100

http://purl.obolibrary.org/obo/dinto_DB00794

http://purl.obolibrary.org/obo/CHEBI_681569

http://purl.obolibrary.org/obo/dinto_DB00745

http://purl.obolibrary.org/obo/CHEBI_45304

http://purl.obolibrary.org/obo/dinto_DB00291

http://purl.obolibrary.org/obo/CHEBI_8069

http://purl.obolibrary.org/obo/dinto_DB00312

http://purl.obolibrary.org/obo/CHEBI_3699

http://purl.obolibrary.org/obo/dinto_DB01601

http://purl.obolibrary.org/obo/dinto_DB01323

http://purl.obolibrary.org/obo/CHEBI_7824

http://purl.obolibrary.org/obo/dinto_DB00290

http://purl.obolibrary.org/obo/CHEBI_567361

http://purl.obolibrary.org/obo/CHEBI_5138

http://purl.obolibrary.org/obo/CHEBI_3387

http://purl.obolibrary.org/obo/CHEBI_3423

http://purl.obolibrary.org/obo/CHEBI_45367

http://purl.obolibrary.org/obo/dinto_DB01118

http://purl.obolibrary.org/obo/dinto_DB00199

http://purl.obolibrary.org/obo/CHEBI_7447

http://purl.obolibrary.org/obo/CHEBI_7772

http://purl.obolibrary.org/obo/CHEBI_51450

http://purl.obolibrary.org/obo/dinto_DB00503

http://purl.obolibrary.org/obo/dinto_DB01320

http://purl.obolibrary.org/obo/CHEBI_27899

http://purl.obolibrary.org/obo/dinto_DB01026

http://purl.obolibrary.org/obo/CHEBI_28077

http://purl.obolibrary.org/obo/CHEBI_63613

http://purl.obolibrary.org/obo/CHEBI_31355
prefixIRI

obo2:CHEBI_47657
prefLabel

roflumilast
SMILES

FC(F)OC1=C(OCC2CC2)C=C(C=C1)C(=O)NC1=C(Cl)C=NC=C1Cl

FC(F)Oc1ccc(cc1OCC1CC1)C(=O)Nc1c(Cl)cncc1Cl
Synonym

C17H14Cl2F2N2O3

roflumilast

Daliresp

3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide

roflumilastum
xref

CiteXplore:22452977

Patent:US2008221111

PDBeChem:ROF

CiteXplore:22833385

BindingDB:14774

CiteXplore:22500119

CiteXplore:21778965

PDB:ROF

ChEBI:47657

PubChem Compound:449193

KEGG DRUG:D05744

Wikipedia:http://en.wikipedia.org/wiki/Roflumilast

CASRN:162401-32-3

Drugs.com:http://www.drugs.com/mtm/roflumilast.html

CiteXplore:22041526

CiteXplore:21965226

CiteXplore:22952743

CiteXplore:22790061

Patent:US2008181876

CiteXplore:22723325

CiteXplore:22605906

CiteXplore:22955248

Wikipedia:Roflumilast

CiteXplore:22421519

Reaxys:9802592

CiteXplore:22284994

ChemSpider:395793

CiteXplore:22306235

CiteXplore:21913898

CiteXplore:22425388

CiteXplore:22433610

CiteXplore:22364166

Patent:WO2008090355

Patent:WO2008017827

PubChem Substance:10300323

National Drug Code Directory:0456-0095-30

ChEMBL:421696

CiteXplore:22385203

CiteXplore:22258322

CiteXplore:22791991

CiteXplore:22997924
subClassOf

http://purl.obolibrary.org/obo/dinto_000055
Add comment
Add proposal
Delete Subject Author Type Created
No notes to display
Create mapping

Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_47657 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_47657 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_47657 PDRO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_47657 BERO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_47657 DRON SAME_URI
http://purl.obolibrary.org/obo/CHEBI_47657 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_47657 CHEBI LOOM
http://purl.bioontology.org/ontology/NDDF/013499 NDDF LOOM
http://www.phoc.org.cn/pmo/class/PMO_00026761 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/ATC/R03DX07 ATC LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000750521 PDQ LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0965618 OCHV LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/448971002 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/VANDF/4030722 VANDF LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C76890 NCIT LOOM
http://purl.obolibrary.org/obo/CHEBI_47657 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_47657 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_47657 DRON LOOM
http://purl.bioontology.org/ontology/RXNORM/1091836 RXNORM LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000182732 NDFRT LOOM
http://purl.bioontology.org/ontology/MESH/C424423 MESH LOOM
http://purl.obolibrary.org/obo/NCIT_C76890 BERO LOOM
https://go.drugbank.com/drugs/DB01656 MDM LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#53590 OCHV LOOM
http://www.drugbank.ca/drugs/DB01656 FTC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C424423 RH-MESH LOOM