The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	tramadol hydrochloride
Synonyms	(1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexan-1-ol (+-)-tramadol hydrochloride C16H25NO2 tramadol monohydrochloride C16H25NO2.HCl Tramadol HCl racemic tramadol hydrochloride (+-)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol hydrochloride rac-(1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol hydrochloride
ID	http://purl.obolibrary.org/obo/CHEBI_32250
activates	http://purl.obolibrary.org/obo/dinto_0760 http://purl.obolibrary.org/obo/dinto_2787 http://purl.obolibrary.org/obo/dinto_3960
AHFScode	28:08.08
altId	CHEBI:75732
ATCCode	N02AX02
binds	http://purl.obolibrary.org/obo/dinto_2714 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_0068 http://purl.obolibrary.org/obo/dinto_2787 http://purl.obolibrary.org/obo/dinto_2150 http://purl.obolibrary.org/obo/dinto_0510 http://purl.obolibrary.org/obo/dinto_3364 http://purl.obolibrary.org/obo/dinto_1005 http://purl.obolibrary.org/obo/dinto_0760 http://purl.obolibrary.org/obo/dinto_3960 http://purl.obolibrary.org/obo/dinto_0465
blocks	http://purl.obolibrary.org/obo/dinto_2150 http://purl.obolibrary.org/obo/dinto_0510 http://purl.obolibrary.org/obo/dinto_3364 http://purl.obolibrary.org/obo/dinto_1005
CASRN	27203-92-5
DBBrand	tridural durela tramal zytram xl ralivia flashtab ultram crispin ralivia er conzip tramadol hcl bp/ep rybix ultram er
DBname	tramadol
DBSalt	tramadol hydrochloride
Definition	A racemate consisting of equal amounts of (R,R)- and (S,S)-tramadol hydrochloride. A centrally acting synthetic opioid analgesic, used to treat moderately severe pain. The (R,R)-enantiomer exhibits ten-fold higher analgesic potency than the (S,S)-enantiomer.
has pharmacological target	http://purl.obolibrary.org/obo/dinto_2714 http://purl.obolibrary.org/obo/dinto_0068 http://purl.obolibrary.org/obo/dinto_2787
has role	http://purl.obolibrary.org/obo/CHEBI_64054 http://purl.obolibrary.org/obo/CHEBI_50949 http://purl.obolibrary.org/obo/CHEBI_48878 http://purl.obolibrary.org/obo/CHEBI_48876 http://purl.obolibrary.org/obo/CHEBI_60797 http://purl.obolibrary.org/obo/CHEBI_55322 http://purl.obolibrary.org/obo/CHEBI_48279 http://purl.obolibrary.org/obo/CHEBI_70774 http://purl.obolibrary.org/obo/CHEBI_35640 http://purl.obolibrary.org/obo/CHEBI_59282 http://purl.obolibrary.org/obo/CHEBI_51177 http://purl.obolibrary.org/obo/CHEBI_35482
InChI	InChI=1S/C16H25NO2/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3/t14-,16+/m1/s1
InChIKey	InChIKey=TVYLLZQTGLZFBW-ZBFHGGJFSA-N
inhibits	http://purl.obolibrary.org/obo/dinto_2714 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_0068
is metabolised by	http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_0465
is substrate of	http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_0465
label	tramadol hydrochloride
modulates	http://purl.obolibrary.org/obo/dinto_2150 http://purl.obolibrary.org/obo/dinto_0510 http://purl.obolibrary.org/obo/dinto_3364 http://purl.obolibrary.org/obo/dinto_1005 http://purl.obolibrary.org/obo/dinto_0760 http://purl.obolibrary.org/obo/dinto_2787 http://purl.obolibrary.org/obo/dinto_3960
prefixIRI	obo2:CHEBI_32250
prefLabel	tramadol hydrochloride
SMILES	COC1=CC=CC(=C1)[C@@]1(O)CCCC[C@@H]1CN(C)C
Synonym	(1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexan-1-ol (+-)-tramadol hydrochloride C16H25NO2 tramadol monohydrochloride C16H25NO2.HCl Tramadol HCl racemic tramadol hydrochloride (+-)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol hydrochloride rac-(1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol hydrochloride
xref	PubChem Compound:33741 CiteXplore:23029946 CiteXplore:22918011 DrugBank:DB00193 CiteXplore:24028179 CiteXplore:23521170 National Drug Code Directory:0045-0659-60 CiteXplore:23724656 CiteXplore:22871232 CASRN:36282-47-0 CiteXplore:23786206 CiteXplore:22849674 PubChem Substance:46506256 CiteXplore:23103596 CiteXplore:23031839 PharmGKB:PA451735 KEGG DRUG:D01355 CiteXplore:23428887 CiteXplore:23789213 CiteXplore:21950732 Reaxys:9237274 Reaxys:6640634 CiteXplore:23802666 CiteXplore:23668411 CiteXplore:23363343 CiteXplore:22959557 CiteXplore:23203185 CiteXplore:24019801 CiteXplore:22674657 Wikipedia:Tramadol CiteXplore:23066205 Wikipedia:http://en.wikipedia.org/wiki/Tramadol Reaxys:6579261 Patent:US2013011444 CiteXplore:23351340 Drugs.com:http://www.drugs.com/tramadol.html CiteXplore:23071920 CiteXplore:22896821 ChemSpider:31105 CiteXplore:23249424 RxList:http://www.rxlist.com/cgi/generic/tramadol.htm BindingDB:50176262
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_32250	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_32250	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_32250	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_32250	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_32250	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_32250	BERO	LOOM
http://www.co-ode.org/ontologies/galen#TramadolHydrochloride	GALEN	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29508	NCIT	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#27572	OCHV	LOOM
http://purl.bioontology.org/ontology/RXNORM/82110	RXNORM	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148400	NDFRT	LOOM
http://purl.obolibrary.org/obo/NCIT_C29508	BERO	LOOM
http://purl.bioontology.org/ontology/VANDF/4020912	VANDF	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/108505002	SNOMEDCT	LOOM