The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	amifostine
Synonyms	amifostina Amifostine ({2-[(3-aminopropyl)amino]ethyl}sulfanyl)phosphonic acid S-{2-[(3-aminopropyl)amino]ethyl} dihydrogen thiophosphate amifostine amifostinum C5H15N2O3PS Ethyol
ID	http://purl.obolibrary.org/obo/CHEBI_2636
AHFScode	92:00.00
ATCCode	V03AF05
binds	http://purl.obolibrary.org/obo/dinto_0272 http://purl.obolibrary.org/obo/dinto_4071 http://purl.obolibrary.org/obo/dinto_0383
CASRN	20537-88-6
DBBrand	ethyol
DBname	amifostine
DBSynonym	sapep gammaphos aminopropylaminoethyl thiophosphate amifostine ethiofos ethiofos apaetp wr-1065
Definition	A thiophosphate that is the S-phospho derivative of 2-[(3-aminopropyl)amino]ethanethiol. A prodrug for the free thiol, WR-1065, which is used as a cytoprotectant in cancer chemotherapy and radiotherapy.
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000449 http://purl.obolibrary.org/obo/OAE_0001437 http://purl.obolibrary.org/obo/OAE_0000391 http://purl.obolibrary.org/obo/OAE_0000218 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000659 http://purl.obolibrary.org/obo/OAE_0000617 http://purl.obolibrary.org/obo/OAE_0000198 http://purl.obolibrary.org/obo/OAE_0000406 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000021 http://purl.obolibrary.org/obo/OAE_0000660 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0000403 http://purl.obolibrary.org/obo/OAE_0001055 http://purl.obolibrary.org/obo/OAE_0000454 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0001200 http://purl.obolibrary.org/obo/OAE_0000400 http://purl.obolibrary.org/obo/OAE_0000086 http://purl.obolibrary.org/obo/OAE_0000645 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000038 http://purl.obolibrary.org/obo/OAE_0000866 http://purl.obolibrary.org/obo/OAE_0000306 http://purl.obolibrary.org/obo/OAE_0000390 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0000394 http://purl.obolibrary.org/obo/OAE_0001364
has pharmacological target	http://purl.obolibrary.org/obo/dinto_4071
has role	http://purl.obolibrary.org/obo/CHEBI_22586 http://purl.obolibrary.org/obo/CHEBI_66987 http://purl.obolibrary.org/obo/CHEBI_50266
InChI	InChI=1S/C5H15N2O3PS/c6-2-1-3-7-4-5-12-11(8,9)10/h7H,1-6H2,(H2,8,9,10)
InChIKey	InChIKey=JKOQGQFVAUAYPM-UHFFFAOYSA-N
induces	http://purl.obolibrary.org/obo/dinto_4071 http://purl.obolibrary.org/obo/dinto_0383
label	amifostine
may interact with	http://purl.obolibrary.org/obo/dinto_DB00519 http://purl.obolibrary.org/obo/CHEBI_9948 http://purl.obolibrary.org/obo/dinto_DB00839 http://purl.obolibrary.org/obo/CHEBI_9434 http://purl.obolibrary.org/obo/CHEBI_3640 http://purl.obolibrary.org/obo/CHEBI_9927 http://purl.obolibrary.org/obo/dinto_DB01021 http://purl.obolibrary.org/obo/dinto_DB00214 http://purl.obolibrary.org/obo/CHEBI_9445 http://purl.obolibrary.org/obo/CHEBI_68845
prefixIRI	obo2:CHEBI_2636
prefLabel	amifostine
related with	http://purl.obolibrary.org/obo/dinto_0272
SMILES	NCCCNCCSP(O)(O)=O
Synonym	amifostina Amifostine ({2-[(3-aminopropyl)amino]ethyl}sulfanyl)phosphonic acid S-{2-[(3-aminopropyl)amino]ethyl} dihydrogen thiophosphate amifostine amifostinum C5H15N2O3PS Ethyol
xref	CiteXplore:22402174 CiteXplore:12005544 RxList:http://www.rxlist.com/cgi/generic/amifostine.htm CiteXplore:22643562 PharmGKB:PA448365 CiteXplore:23052919 CiteXplore:22267539 CiteXplore:21646919 CiteXplore:20334641 CiteXplore:15875769 CiteXplore:12751907 CiteXplore:16465691 PubChem Substance:46505305 PubChem Compound:2141 Beilstein:2088122 CiteXplore:12561384 CiteXplore:22989457 Wikipedia:Amifostine CiteXplore:21347716 CiteXplore:15698860 CiteXplore:18549666 Drugs Product Database (DPD):2218054 HMDB:HMDB15274 Wikipedia:http://en.wikipedia.org/wiki/Amifostine CiteXplore:14980067 ChemSpider:2056 KEGG COMPOUND:C06819 CiteXplore:11984063 Patent:US3892824 CiteXplore:8612469 CiteXplore:22885239 CiteXplore:22456378 CiteXplore:22496587 CiteXplore:18072151 ChEMBL:212480 CiteXplore:23092832 Reaxys:2088122 CiteXplore:19712749 CiteXplore:8683243 CiteXplore:11013273 CiteXplore:15380592 CiteXplore:12499421 CiteXplore:17602063 DrugBank:DB01143 CASRN:20537-88-6 National Drug Code Directory:58178-017-01 ChEBI:2636 CiteXplore:22844290 CiteXplore:10942928 CiteXplore:11201306 CiteXplore:22878481 CiteXplore:12433814 Drugs.com:http://www.drugs.com/cdi/amifostine.html CiteXplore:23401928 CiteXplore:10553165 CiteXplore:23040218 CiteXplore:22440042
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_2636	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_2636	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_2636	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_2636	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_2636	BIOMODELS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_2636	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_2636	NIFSTD	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_2636	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_2636	CHEBI	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148443	NDFRT	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C488	NCIT	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D004999	RH-MESH	LOOM
http://purl.bioontology.org/ontology/ATC/V03AF05	ATC	LOOM
http://purl.bioontology.org/ontology/RCD/h95..	RCD	LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000039741	PDQ	LOOM
http://purl.jp/bio/4/id/200906085160389070	IOBC	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.705.400.625.050	RH-MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.300.692.050	RH-MESH	LOOM
http://purl.obolibrary.org/obo/OMIT_0006228	OMIT	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.705.539.345.050	RH-MESH	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0015020	OCHV	LOOM
http://purl.bioontology.org/ontology/MESH/D004999	MESH	LOOM
http://purl.bioontology.org/ontology/VANDF/4020970	VANDF	LOOM
http://www.drugbank.ca/drugs/DB01143	FTC	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017307	PMAPP-PMO	LOOM
http://purl.bioontology.org/ontology/NDDF/005536	NDDF	LOOM
http://purl.bioontology.org/ontology/RXNORM/4126	RXNORM	LOOM
http://www.co-ode.org/ontologies/galen#Amifostine	GALEN	LOOM
http://stirdf.jst.go.jp/id/200907083247191839	IOBC	LOOM
http://purl.obolibrary.org/obo/CHEBI_2636	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_2636	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_2636	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_2636	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_2636	NIFSTD	LOOM
http://purl.obolibrary.org/obo/NCIT_C488	BERO	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386923005	SNOMEDCT	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#4699	OCHV	LOOM
https://go.drugbank.com/drugs/DB01143	MDM	LOOM
http://purl.obolibrary.org/obo/MESH_D004999	BERO	LOOM