loading...| Preferred Name |
cortisol |
|
| Synonyms |
(1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one (11beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione 4-pregnen-11beta,17alpha,21-triol-3,20-dione Reichstein's substance M C21H30O5 Kendall's compound F hydrocortisone 11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione hydrocortisonum hidrocortisona 17-hydroxycorticosterone 11beta,17alpha,21-trihydroxy-4-pregnene-3,20-dione Cortisol Hydrocortisone 11beta-hydrocortisone cortisol 11beta,17,21-trihydroxypregn-4-ene-3,20-dione |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_17650 |
|
| activates | ||
| AHFScode |
84:06.00 52:08.08 68:04.00 |
|
| altId |
CHEBI:24633 CHEBI:58221 CHEBI:3893 CHEBI:14023 |
|
| ATCCode |
S02BA01 D07AC16 S01BA02 D07AB02 D07AB11 A01AC03 A07EA02 H02AB09 D07AA02 C05AA01 D07XA01 S01CB03 |
|
| CASRN |
50-23-7 |
|
| DBBrand |
hydro-colisona amberin nogenic hc nutracort micort-hc hycortole stie-cort cort-dome genacort cortolotion hytone lotion traumaide cutisol proctofoam sigmacort cortiment orabase hca texacort lotion 25 prepcort compound f lubricort vytone dermolate domolene-hc hytisone uniderm algicirtis aeroseb-hc aquanil hc schericur tarcortin alacort derm-aid cobadex cortifoam acticort lacticare-hc stiefcorcil lacticare hc aquacort foille insetti protocort cortenema hydro-adreson neosporin-h ear hydroskin hycort eldecort texacort drotic cortoxide polcort h prevex hc kyypakkaus cortisolonum flexicort ficortril preparation h hydrocortisone cream transderma h clear aid optef synacort lactisona dermocortal pandel hydrocortistab hemsol-hc maintasone dricort pediotic suspension cortef dermil hydracort systral hydrocort urocortisone westcort cortifan thyrotropic-releasing factor incortin-h h-cort scalpicin capilar epicort esiderm h locoid zenoxone efcortelan vosol hc signef anflam medicort cortonema anusol hc cortisporin otico ala-cort dermaspray hydrocortal tetrahydro e efcorbin locoid lipocream tetrahydrocompound e hi-cor balneol-hc hycortol permicort proctocort otobiotic cortef acetate heb cort aeroseb hc delacort basan-corti hytone milliderm epiderm h otosone-f hidro-colisona cortispray evacort otocort ef corlin kendall's compound f heb-cort cortril dioderm cremesone incortin-hydrogen hydrasson remederm hc hidalone timocort colocort cortisporin meusicort fiocortril penecort cetacort eldercort cortisol alcohol alphaderm cortanal gyno-cortisone hydrocortone dome-cort cleiton nystaform-hc cortesal glycort cortaid cremicort-h caldecort spray cortisol reichstein's substance m rectoid corticreme dermacort scheroson f ala-scalp beta-hc barseb hc sanatison mildison komed hc efcortelin hydrocortisyl |
|
| DBname |
hydrocortisone |
|
| DBSynonym |
hydrocortisone sodium phosphate hydrocortisone base hydrocortisonum [inn-latin] idrocortisone [dcit] hydrocortisone free alcohol 11beta-hydroxycortisone hydrocorticosterone hydrocortisone acetate hydroxycortisone dihydrocostisone hydrocortisone alcohol hydrocortisone valerate 17alpha-hydroxycorticosterone hidrocortisona [inn-spanish] anti-inflammatory hormone hydrocortisone butyrate |
|
| Definition |
Cortisol is a corticosteroid hormone or glucocorticoid produced by zona fasciculata of the adrenal cortex, which is a part of the adrenal gland. It is usually referred to as the "stress hormone" as it is involved in response to stress and anxiety, controlled by corticotropin-releasing hormone (CRH). It increases blood pressure and blood sugar, and reduces immune responses |
|
| has effect |
http://purl.obolibrary.org/obo/OAE_0000785 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000630 http://purl.obolibrary.org/obo/OAE_0000218 http://purl.obolibrary.org/obo/OAE_0000489 http://purl.obolibrary.org/obo/OAE_0001744 http://purl.obolibrary.org/obo/OAE_0000913 http://purl.obolibrary.org/obo/OAE_0001449 http://purl.obolibrary.org/obo/OAE_0001360 http://purl.obolibrary.org/obo/OAE_0000195 http://purl.obolibrary.org/obo/OAE_0000577 http://purl.obolibrary.org/obo/OAE_0000418 http://purl.obolibrary.org/obo/OAE_0000660 http://purl.obolibrary.org/obo/OAE_0000333 http://purl.obolibrary.org/obo/OAE_0000197 http://purl.obolibrary.org/obo/OAE_0001280 http://purl.obolibrary.org/obo/OAE_0001397 http://purl.obolibrary.org/obo/OAE_0000250 http://purl.obolibrary.org/obo/OAE_0001073 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000403 http://purl.obolibrary.org/obo/OAE_0000454 http://purl.obolibrary.org/obo/OAE_0001468 http://purl.obolibrary.org/obo/OAE_0001234 http://purl.obolibrary.org/obo/OAE_0001101 http://purl.obolibrary.org/obo/OAE_0001515 http://purl.obolibrary.org/obo/OAE_0001070 http://purl.obolibrary.org/obo/OAE_0001529 http://purl.obolibrary.org/obo/OAE_0000400 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0000894 http://purl.obolibrary.org/obo/OAE_0000243 http://purl.obolibrary.org/obo/OAE_0000469 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000525 http://purl.obolibrary.org/obo/OAE_0000789 http://purl.obolibrary.org/obo/OAE_0000038 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0001276 http://purl.obolibrary.org/obo/OAE_0000460 http://purl.obolibrary.org/obo/OAE_0000401 http://purl.obolibrary.org/obo/OAE_0000780 http://purl.obolibrary.org/obo/OAE_0000306 http://purl.obolibrary.org/obo/OAE_0000779 http://purl.obolibrary.org/obo/OAE_0000390 http://purl.obolibrary.org/obo/OAE_0001291 http://purl.obolibrary.org/obo/OAE_0000565 http://purl.obolibrary.org/obo/OAE_0001345 http://purl.obolibrary.org/obo/OAE_0000501 http://purl.obolibrary.org/obo/OAE_0000374 |
|
| has pharmacological target | ||
| has role |
http://purl.obolibrary.org/obo/CHEBI_35472 |
|
| InChI |
InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1 |
|
| InChIKey |
InChIKey=JYGXADMDTFJGBT-VWUMJDOOSA-N |
|
| induces | ||
| inhibits |
http://purl.obolibrary.org/obo/dinto_0883 http://purl.obolibrary.org/obo/dinto_1987 |
|
| is metabolised by |
http://purl.obolibrary.org/obo/dinto_2667 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_0901 |
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| is transported by | ||
| label |
cortisol |
|
| may interact with |
http://purl.obolibrary.org/obo/dinto_DB01401 http://purl.obolibrary.org/obo/CHEBI_102524 http://purl.obolibrary.org/obo/dinto_DB01399 http://purl.obolibrary.org/obo/CHEBI_8107 http://purl.obolibrary.org/obo/dinto_DB00794 http://purl.obolibrary.org/obo/CHEBI_9939 http://purl.obolibrary.org/obo/dinto_DB00306 http://purl.obolibrary.org/obo/CHEBI_4888 http://purl.obolibrary.org/obo/dinto_DB01355 http://purl.obolibrary.org/obo/dinto_DB01397 http://purl.obolibrary.org/obo/dinto_DB01294 http://purl.obolibrary.org/obo/dinto_DB01122 http://purl.obolibrary.org/obo/CHEBI_68610 http://purl.obolibrary.org/obo/CHEBI_102216 http://purl.obolibrary.org/obo/CHEBI_15365 http://purl.obolibrary.org/obo/dinto_DB00532 http://purl.obolibrary.org/obo/CHEBI_8069 http://purl.obolibrary.org/obo/dinto_DB00312 http://purl.obolibrary.org/obo/CHEBI_53766 http://purl.obolibrary.org/obo/dinto_DB01354 http://purl.obolibrary.org/obo/CHEBI_133809 http://purl.obolibrary.org/obo/dinto_DB00545 http://purl.obolibrary.org/obo/dinto_DB00237 http://purl.obolibrary.org/obo/dinto_DB01352 http://purl.obolibrary.org/obo/CHEBI_7514 http://purl.obolibrary.org/obo/CHEBI_6758 http://purl.obolibrary.org/obo/CHEBI_10033 http://purl.obolibrary.org/obo/dinto_DB01351 http://purl.obolibrary.org/obo/dinto_DB00382 http://purl.obolibrary.org/obo/CHEBI_6933 http://purl.obolibrary.org/obo/CHEBI_251408 http://purl.obolibrary.org/obo/CHEBI_4513 http://purl.obolibrary.org/obo/dinto_DB00072 http://purl.obolibrary.org/obo/dinto_DB01320 http://purl.obolibrary.org/obo/CHEBI_68575 http://purl.obolibrary.org/obo/CHEBI_28077 http://purl.obolibrary.org/obo/CHEBI_59602 http://purl.obolibrary.org/obo/dinto_DB01432 http://purl.obolibrary.org/obo/dinto_DB01346 http://purl.obolibrary.org/obo/dinto_DB01353 http://purl.obolibrary.org/obo/dinto_DB01341 |
|
| prefixIRI |
obo2:CHEBI_17650 |
|
| prefLabel |
cortisol |
|
| related with | ||
| SMILES |
[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]1(C)[C@@]2([H])CC[C@]1(O)C(=O)CO [H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C |
|
| Synonym |
(1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one (11beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione 4-pregnen-11beta,17alpha,21-triol-3,20-dione Reichstein's substance M C21H30O5 Kendall's compound F hydrocortisone 11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione hydrocortisonum hidrocortisona 17-hydroxycorticosterone 11beta,17alpha,21-trihydroxy-4-pregnene-3,20-dione Cortisol Hydrocortisone 11beta-hydrocortisone cortisol 11beta,17,21-trihydroxypregn-4-ene-3,20-dione |
|
| xref |
NIST Chemistry WebBook:50-23-7 Drugs Product Database (DPD):2242930 National Drug Code Directory:0009-0142-01 DrugBank:DB00741 PDB:PDN KEGG COMPOUND:C00735 LIPID MAPS:LMST02030001 Beilstein:1354819 Guide To Pharmacology:2868 ChemSpider:5551 KEGG DRUG:D00088 PubChem Substance:46505089 CASRN:50-23-7 ChEBI:17650 Drugs.com:http://www.drugs.com/cdi/hydrocortisone.html IUPHAR:2868 PubChem Compound:5754 PDRhealth:http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/hyd1199.shtml Wikipedia:http://en.wikipedia.org/wiki/Hydrocortisone PharmGKB:PA449905 RxList:http://www.rxlist.com/cgi/generic/hydrocortisone.htm ChEMBL:474052 CiteXplore:10438974 Patent:US2602769 Wikipedia:Hydrocortisone BindingDB:22476 |
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| subClassOf |