The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Preferred Name

cortisol

Synonyms

11beta,17,21-trihydroxypregn-4-ene-3,20-dione

(1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one

hydrocortisone

Reichstein's substance M

C21H30O5

11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione

hidrocortisona

11beta,17alpha,21-trihydroxy-4-pregnene-3,20-dione

Cortisol

17-hydroxycorticosterone

Hydrocortisone

(11beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione

cortisol

Kendall's compound F

hydrocortisonum

4-pregnen-11beta,17alpha,21-triol-3,20-dione

11beta-hydrocortisone

ID

http://purl.obolibrary.org/obo/CHEBI_17650

activates

http://purl.obolibrary.org/obo/dinto_0764

http://purl.obolibrary.org/obo/dinto_2874

AHFScode

84:06.00

52:08.08

68:04.00

altId

CHEBI:58221

CHEBI:24633

CHEBI:14023

CHEBI:3893

ATCCode

S01CB03

D07AB11

D07AC16

S01BA02

H02AB09

A01AC03

A07EA02

D07AA02

C05AA01

S02BA01

D07XA01

D07AB02

CASRN

50-23-7

DBBrand

cortef acetate

aquanil hc

cremicort-h

clear aid

cleiton

hi-cor

efcortelan

drotic

hydrasson

anflam

signef

lubricort

nystaform-hc

hytisone

beta-hc

lacticare hc

traumaide

cortenema

cortisol alcohol

cortisporin

gyno-cortisone

sigmacort

pediotic suspension

otobiotic

colocort

aquacort

cortisolonum

mildison

alphaderm

hydrocortone

stie-cort

timocort

dioderm

proctofoam

milliderm

meusicort

dricort

cortifoam

lacticare-hc

micort-hc

balneol-hc

kendall's compound f

uniderm

permicort

protocort

polcort h

tarcortin

komed hc

hemsol-hc

ef corlin

cort-dome

cortoxide

eldercort

lactisona

hidro-colisona

alacort

incortin-hydrogen

cortesal

kyypakkaus

hydro-adreson

schericur

dermil

incortin-h

hydrocortistab

dermocortal

scheroson f

dermacort

genacort

foille insetti

cortanal

optef

cobadex

locoid

hycortol

sanatison

dome-cort

penecort

vosol hc

aeroseb hc

maintasone

remederm hc

hydro-colisona

algicirtis

basan-corti

cortaid

dermaspray

compound f

fiocortril

nogenic hc

cortispray

locoid lipocream

amberin

rectoid

caldecort spray

epicort

hydracort

h-cort

westcort

hytone

anusol hc

otocort

pandel

cortril

prepcort

hydrocortal

hidalone

prevex hc

delacort

domolene-hc

derm-aid

hycortole

barseb hc

neosporin-h ear

cortisporin otico

zenoxone

cortiment

tetrahydro e

acticort

cutisol

proctocort

orabase hca

cetacort

texacort lotion 25

ala-scalp

heb-cort

cortifan

hycort

medicort

stiefcorcil

epiderm h

texacort

dermolate

urocortisone

synacort

transderma h

cortisol

cortonema

flexicort

cortef

vytone

esiderm h

aeroseb-hc

heb cort

systral hydrocort

reichstein's substance m

hydrocortisyl

ficortril

glycort

nutracort

tetrahydrocompound e

efcortelin

efcorbin

cremesone

evacort

cortolotion

corticreme

hytone lotion

thyrotropic-releasing factor

otosone-f

hydroskin

eldecort

scalpicin capilar

preparation h hydrocortisone cream

ala-cort

DBname

hydrocortisone

DBSynonym

hydrocortisonum [inn-latin]

anti-inflammatory hormone

hydrocortisone base

hidrocortisona [inn-spanish]

hydrocortisone alcohol

hydrocortisone free alcohol

hydrocortisone sodium phosphate

hydrocortisone acetate

17alpha-hydroxycorticosterone

11beta-hydroxycortisone

dihydrocostisone

idrocortisone [dcit]

hydrocortisone valerate

hydroxycortisone

hydrocorticosterone

hydrocortisone butyrate

Definition

Cortisol is a corticosteroid hormone or glucocorticoid produced by zona fasciculata of the adrenal cortex, which is a part of the adrenal gland. It is usually referred to as the "stress hormone" as it is involved in response to stress and anxiety, controlled by corticotropin-releasing hormone (CRH). It increases blood pressure and blood sugar, and reduces immune responses

has effect

http://purl.obolibrary.org/obo/OAE_0000355

http://purl.obolibrary.org/obo/OAE_0001101

http://purl.obolibrary.org/obo/OAE_0000400

http://purl.obolibrary.org/obo/OAE_0000390

http://purl.obolibrary.org/obo/OAE_0000401

http://purl.obolibrary.org/obo/OAE_0000377

http://purl.obolibrary.org/obo/OAE_0001345

http://purl.obolibrary.org/obo/OAE_0000218

http://purl.obolibrary.org/obo/OAE_0000577

http://purl.obolibrary.org/obo/OAE_0001035

http://purl.obolibrary.org/obo/OAE_0000333

http://purl.obolibrary.org/obo/OAE_0001070

http://purl.obolibrary.org/obo/OAE_0001280

http://purl.obolibrary.org/obo/OAE_0001291

http://purl.obolibrary.org/obo/OAE_0001449

http://purl.obolibrary.org/obo/OAE_0000600

http://purl.obolibrary.org/obo/OAE_0000197

http://purl.obolibrary.org/obo/OAE_0000913

http://purl.obolibrary.org/obo/OAE_0000489

http://purl.obolibrary.org/obo/OAE_0000789

http://purl.obolibrary.org/obo/OAE_0000418

http://purl.obolibrary.org/obo/OAE_0001234

http://purl.obolibrary.org/obo/OAE_0000894

http://purl.obolibrary.org/obo/OAE_0000501

http://purl.obolibrary.org/obo/OAE_0000780

http://purl.obolibrary.org/obo/OAE_0000306

http://purl.obolibrary.org/obo/OAE_0001468

http://purl.obolibrary.org/obo/OAE_0000374

http://purl.obolibrary.org/obo/OAE_0000630

http://purl.obolibrary.org/obo/OAE_0000250

http://purl.obolibrary.org/obo/OAE_0001744

http://purl.obolibrary.org/obo/OAE_0002206

http://purl.obolibrary.org/obo/OAE_0001515

http://purl.obolibrary.org/obo/OAE_0000469

http://purl.obolibrary.org/obo/OAE_0000785

http://purl.obolibrary.org/obo/OAE_0001276

http://purl.obolibrary.org/obo/OAE_0000195

http://purl.obolibrary.org/obo/OAE_0000403

http://purl.obolibrary.org/obo/OAE_0000565

http://purl.obolibrary.org/obo/OAE_0000460

http://purl.obolibrary.org/obo/OAE_0000034

http://purl.obolibrary.org/obo/OAE_0001360

http://purl.obolibrary.org/obo/OAE_0000243

http://purl.obolibrary.org/obo/OAE_0000454

http://purl.obolibrary.org/obo/OAE_0000038

http://purl.obolibrary.org/obo/OAE_0001397

http://purl.obolibrary.org/obo/OAE_0001073

http://purl.obolibrary.org/obo/OAE_0001398

http://purl.obolibrary.org/obo/OAE_0000660

http://purl.obolibrary.org/obo/OAE_0000525

http://purl.obolibrary.org/obo/OAE_0000779

http://purl.obolibrary.org/obo/OAE_0001529

has pharmacological target

http://purl.obolibrary.org/obo/dinto_0764

http://purl.obolibrary.org/obo/dinto_2874

has role

http://purl.obolibrary.org/obo/CHEBI_50857

http://purl.obolibrary.org/obo/CHEBI_49167

http://purl.obolibrary.org/obo/CHEBI_35472

InChI

InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1

InChIKey

InChIKey=JYGXADMDTFJGBT-VWUMJDOOSA-N

induces

http://purl.obolibrary.org/obo/dinto_1221

inhibits

http://purl.obolibrary.org/obo/dinto_0901

http://purl.obolibrary.org/obo/dinto_0883

http://purl.obolibrary.org/obo/dinto_1987

http://purl.obolibrary.org/obo/dinto_1440

is metabolised by

http://purl.obolibrary.org/obo/dinto_1956

http://purl.obolibrary.org/obo/dinto_2990

http://purl.obolibrary.org/obo/dinto_0901

http://purl.obolibrary.org/obo/dinto_2667

http://purl.obolibrary.org/obo/dinto_0278

is transported by

http://purl.obolibrary.org/obo/dinto_1440

label

cortisol

may interact with

http://purl.obolibrary.org/obo/dinto_DB01294

http://purl.obolibrary.org/obo/CHEBI_9073

http://purl.obolibrary.org/obo/dinto_DB01346

http://purl.obolibrary.org/obo/dinto_DB01397

http://purl.obolibrary.org/obo/dinto_DB00237

http://purl.obolibrary.org/obo/CHEBI_10033

http://purl.obolibrary.org/obo/dinto_DB01399

http://purl.obolibrary.org/obo/dinto_DB01320

http://purl.obolibrary.org/obo/dinto_DB01398

http://purl.obolibrary.org/obo/dinto_DB01432

http://purl.obolibrary.org/obo/dinto_DB00312

http://purl.obolibrary.org/obo/CHEBI_4513

http://purl.obolibrary.org/obo/CHEBI_28077

http://purl.obolibrary.org/obo/CHEBI_251408

http://purl.obolibrary.org/obo/dinto_DB01341

http://purl.obolibrary.org/obo/dinto_DB00794

http://purl.obolibrary.org/obo/CHEBI_6758

http://purl.obolibrary.org/obo/dinto_DB00382

http://purl.obolibrary.org/obo/dinto_DB01122

http://purl.obolibrary.org/obo/dinto_DB01353

http://purl.obolibrary.org/obo/CHEBI_7514

http://purl.obolibrary.org/obo/dinto_DB01355

http://purl.obolibrary.org/obo/dinto_DB01352

http://purl.obolibrary.org/obo/CHEBI_133809

http://purl.obolibrary.org/obo/CHEBI_102524

http://purl.obolibrary.org/obo/dinto_DB01401

http://purl.obolibrary.org/obo/dinto_DB01354

http://purl.obolibrary.org/obo/dinto_DB00306

http://purl.obolibrary.org/obo/CHEBI_15365

http://purl.obolibrary.org/obo/dinto_DB00072

http://purl.obolibrary.org/obo/dinto_DB00545

http://purl.obolibrary.org/obo/dinto_DB00532

http://purl.obolibrary.org/obo/dinto_DB01351

http://purl.obolibrary.org/obo/CHEBI_53766

http://purl.obolibrary.org/obo/CHEBI_68575

http://purl.obolibrary.org/obo/CHEBI_8069

http://purl.obolibrary.org/obo/CHEBI_102216

http://purl.obolibrary.org/obo/CHEBI_59602

http://purl.obolibrary.org/obo/CHEBI_68610

http://purl.obolibrary.org/obo/CHEBI_8107

http://purl.obolibrary.org/obo/CHEBI_9939

http://purl.obolibrary.org/obo/CHEBI_4888

http://purl.obolibrary.org/obo/CHEBI_6933

prefixIRI

obo2:CHEBI_17650

prefLabel

cortisol

related with

http://purl.obolibrary.org/obo/dinto_3535

SMILES

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]1(C)[C@@]2([H])CC[C@]1(O)C(=O)CO

[H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C

Synonym

11beta,17,21-trihydroxypregn-4-ene-3,20-dione

(1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one

hydrocortisone

Reichstein's substance M

C21H30O5

11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione

hidrocortisona

11beta,17alpha,21-trihydroxy-4-pregnene-3,20-dione

Cortisol

17-hydroxycorticosterone

Hydrocortisone

(11beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione

cortisol

Kendall's compound F

hydrocortisonum

4-pregnen-11beta,17alpha,21-triol-3,20-dione

11beta-hydrocortisone

xref

BindingDB:22476

PubChem Substance:46505089

DrugBank:DB00741

CASRN:50-23-7

Wikipedia:Hydrocortisone

LIPID MAPS:LMST02030001

PubChem Compound:5754

Patent:US2602769

KEGG DRUG:D00088

PharmGKB:PA449905

Drugs.com:http://www.drugs.com/cdi/hydrocortisone.html

CiteXplore:10438974

RxList:http://www.rxlist.com/cgi/generic/hydrocortisone.htm

ChemSpider:5551

Wikipedia:http://en.wikipedia.org/wiki/Hydrocortisone

ChEMBL:474052

PDB:PDN

National Drug Code Directory:0009-0142-01

PDRhealth:http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/hyd1199.shtml

KEGG COMPOUND:C00735

ChEBI:17650

Guide To Pharmacology:2868

Beilstein:1354819

IUPHAR:2868

NIST Chemistry WebBook:50-23-7

Drugs Product Database (DPD):2242930

subClassOf

http://purl.obolibrary.org/obo/dinto_000055

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http://purl.obolibrary.org/obo/CHEBI_24633 NIFSTD LOOM
http://purl.bioontology.org/ontology/CPT/1011359 CPT LOOM
http://localhost/plosthes.2017-1#3025 PLOSTHES LOOM
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http://sbmi.uth.tmc.edu/ontology/ochv#C0020268 OCHV LOOM
http://purl.bioontology.org/ontology/SNMI/F-B2860 SNMI LOOM
http://www.co-ode.org/ontologies/galen#Cortisol GALEN LOOM
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http://purl.obolibrary.org/obo/CHEBI_17650 CHEBI LOOM
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http://purl.obolibrary.org/obo/CHEBI_17650 DRON SAME_URI
http://purl.obolibrary.org/obo/CHEBI_17650 MCO LOOM
http://purl.obolibrary.org/obo/CHEBI_17650 MCO SAME_URI
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http://purl.obolibrary.org/obo/CHEBI_17650 UPHENO LOOM
http://purl.obolibrary.org/obo/CHEBI_17650 UPHENO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_17650 ZP LOOM
http://purl.obolibrary.org/obo/CHEBI_17650 ZP SAME_URI
http://purl.obolibrary.org/obo/CHEBI_17650 HINO LOOM
http://purl.obolibrary.org/obo/CHEBI_17650 HINO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_17650 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_17650 NIFSTD SAME_URI
http://purl.obolibrary.org/obo/CHEBI_17650 OBA LOOM
http://purl.obolibrary.org/obo/CHEBI_17650 OBA SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3893 NIFSTD LOOM
http://purl.bioontology.org/ontology/CSP/0059-6967 CRISP LOOM
http://www.bioontology.org/pma.owl#PMA_197 PMA LOOM
http://stirdf.jst.go.jp/id/200907056359403483 IOBC LOOM
http://purl.bioontology.org/ontology/LNC/LP70288-3 LOINC LOOM
http://purl.bioontology.org/ontology/MEDDRA/10011195 MEDDRA LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2290 NCIT LOOM
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http://purl.obolibrary.org/obo/CHEBI_14023 NIFSTD LOOM