Preferred Name |
romiplostim |
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Synonyms |
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ID |
http://purl.obolibrary.org/obo/dinto_DB05332 |
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activates | ||
ATCCode |
B02BX04 |
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CASRN |
267639-76-9 |
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DBBrand |
nplate |
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DBSynonym |
amg 531 |
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Definition |
Romiplostim is a thrombopoiesis stimulating dimer Fc-peptide fusion protein (peptibody) to increase platelet production through activation of the thrombopoietin receptor. The peptibody molecule has two identical single-chain subunits, each one is made up of 269 amino acid residues. Each subunit consists of an IgG1 Fc carrier domain that is covalently attached to a polypeptide sequence that contains two binding domains to interact with thrombopoietin receptor c-Mpl. Each domain consists of 14 amino acids. Interestingly, romiplostim s amino acid sequence is not similar to that of endogenous thrombopoietin. Romiplostim is produced by recombinant DNA technology in Escherichia coli. FDA approved on August 22, 2008. |
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has pharmacological target | ||
label |
romiplostim |
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prefixIRI |
obo2:dinto_DB05332 |
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prefLabel |
romiplostim |
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xref |
Wikipedia:http://en.wikipedia.org/wiki/Romiplostim National Drug Code Directory:55513-221-01 |
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subClassOf |