Preferred Name |
polymyxin b sulfate |
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Synonyms |
C56H98N16O13 N-[3-amino-1-({1-[(3-amino-1-{[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl)carbamoyl]-2-hydroxypropyl}carbamoyl)propyl]-6-methyloctanamide |
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ID |
http://purl.obolibrary.org/obo/dinto_DB00781 |
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ATCCode |
S01AA18 S02AA11 A07AA05 J01XB02 S03AA03 |
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binds | ||
CASRN |
1405-20-5 |
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DBBrand |
aerosporin |
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DBSynonym |
polymyxin b sulphate polymixin b sulfate polymyxin b sulfate salt |
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Definition |
Polymyxin B sulfate is a mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic. All gram-positive bacteria, fungi, and the gram-negative cocci, N. gonorrhea and N. menigitidis, are resistant. It is appropriate for treatment of infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of Pseudomonas aeruginosa. |
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has pharmacological target | ||
InChI |
InChI=1S/C56H98N16O13/c1-7-32(4)13-11-12-16-44(75)63-36(17-23-57)51(80)72-46(34(6)74)56(85)68-39(20-26-60)48(77)67-41-22-28-62-55(84)45(33(5)73)71-52(81)40(21-27-61)65-47(76)37(18-24-58)66-53(82)42(29-31(2)3)69-54(83)43(30-35-14-9-8-10-15-35)70-49(78)38(19-25-59)64-50(41)79/h8-10,14-15,31-34,36-43,45-46,73-74H,7,11-13,16-30,57-61H2,1-6H3,(H,62,84)(H,63,75)(H,64,79)(H,65,76)(H,66,82)(H,67,77)(H,68,85)(H,69,83)(H,70,78)(H,71,81)(H,72,80) |
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InChIKey |
InChIKey=WQVJHHACXVLGBL-UHFFFAOYSA-N |
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label |
polymyxin b sulfate |
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may interact with | ||
prefixIRI |
obo2:dinto_DB00781 |
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prefLabel |
polymyxin b sulfate |
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related with | ||
SMILES |
CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CCN)NC1=O)C(C)O |
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Synonym |
C56H98N16O13 N-[3-amino-1-({1-[(3-amino-1-{[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl)carbamoyl]-2-hydroxypropyl}carbamoyl)propyl]-6-methyloctanamide |
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xref |
Drugs Product Database (DPD):2242485 RxList:http://www.rxlist.com/cgi/generic3/polymyxin.htm PubChem Compound:4868 PubChem Substance:46507302 Drugs.com:http://www.drugs.com/mtm/polymyxin-b-ophthalmic.html PharmGKB:PA451027 National Drug Code Directory:55390-139-10 Wikipedia:http://en.wikipedia.org/wiki/Polymyxin_B |
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subClassOf |