The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Preferred Name

polymyxin b sulfate

Synonyms

C56H98N16O13

N-[3-amino-1-({1-[(3-amino-1-{[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl)carbamoyl]-2-hydroxypropyl}carbamoyl)propyl]-6-methyloctanamide

ID

http://purl.obolibrary.org/obo/dinto_DB00781

ATCCode

S01AA18

S02AA11

A07AA05

J01XB02

S03AA03

binds

http://purl.obolibrary.org/obo/dinto_1651

CASRN

1405-20-5

DBBrand

aerosporin

DBSynonym

polymyxin b sulphate

polymixin b sulfate

polymyxin b sulfate salt

Definition

Polymyxin B sulfate is a mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic. All gram-positive bacteria, fungi, and the gram-negative cocci, N. gonorrhea and N. menigitidis, are resistant. It is appropriate for treatment of infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of Pseudomonas aeruginosa.

has pharmacological target

http://purl.obolibrary.org/obo/dinto_1651

InChI

InChI=1S/C56H98N16O13/c1-7-32(4)13-11-12-16-44(75)63-36(17-23-57)51(80)72-46(34(6)74)56(85)68-39(20-26-60)48(77)67-41-22-28-62-55(84)45(33(5)73)71-52(81)40(21-27-61)65-47(76)37(18-24-58)66-53(82)42(29-31(2)3)69-54(83)43(30-35-14-9-8-10-15-35)70-49(78)38(19-25-59)64-50(41)79/h8-10,14-15,31-34,36-43,45-46,73-74H,7,11-13,16-30,57-61H2,1-6H3,(H,62,84)(H,63,75)(H,64,79)(H,65,76)(H,66,82)(H,67,77)(H,68,85)(H,69,83)(H,70,78)(H,71,81)(H,72,80)

InChIKey

InChIKey=WQVJHHACXVLGBL-UHFFFAOYSA-N

label

polymyxin b sulfate

may interact with

http://purl.obolibrary.org/obo/CHEBI_9939

prefixIRI

obo2:dinto_DB00781

prefLabel

polymyxin b sulfate

related with

http://purl.obolibrary.org/obo/dinto_1651

SMILES

CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CCN)NC1=O)C(C)O

Synonym

C56H98N16O13

N-[3-amino-1-({1-[(3-amino-1-{[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl)carbamoyl]-2-hydroxypropyl}carbamoyl)propyl]-6-methyloctanamide

xref

Drugs Product Database (DPD):2242485

RxList:http://www.rxlist.com/cgi/generic3/polymyxin.htm

PubChem Compound:4868

PubChem Substance:46507302

Drugs.com:http://www.drugs.com/mtm/polymyxin-b-ophthalmic.html

PharmGKB:PA451027

National Drug Code Directory:55390-139-10

Wikipedia:http://en.wikipedia.org/wiki/Polymyxin_B

subClassOf

http://purl.obolibrary.org/obo/dinto_000055

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