The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	trastuzumab
Synonyms
ID	http://purl.obolibrary.org/obo/dinto_DB00072
ATCCode	L01XC03
CASRN	180288-69-1
DBBrand	herceptin
DBSynonym	ig gamma-1 chain c region anti her2
Definition	A recombinant IgG1 kappa, humanized monoclonal antibody that selectively binds with high affinity in a cell-based assay (Kd = 5 nM) to the extracellular domain of the human epidermal growth factor receptor protein. Produced in CHO cell culture.*
has pharmacological target	http://purl.obolibrary.org/obo/dinto_0259
inhibits	http://purl.obolibrary.org/obo/dinto_3102
label	trastuzumab
may interact with	http://purl.obolibrary.org/obo/dinto_DB00276 http://purl.obolibrary.org/obo/CHEBI_31348 http://purl.obolibrary.org/obo/CHEBI_5864 http://purl.obolibrary.org/obo/CHEBI_41879 http://purl.obolibrary.org/obo/CHEBI_71417 http://purl.obolibrary.org/obo/CHEBI_2948 http://purl.obolibrary.org/obo/dinto_DB00385 http://purl.obolibrary.org/obo/CHEBI_45863 http://purl.obolibrary.org/obo/CHEBI_49668 http://purl.obolibrary.org/obo/dinto_DB00541 http://purl.obolibrary.org/obo/CHEBI_4672 http://purl.obolibrary.org/obo/CHEBI_28901 http://purl.obolibrary.org/obo/CHEBI_4305 http://purl.obolibrary.org/obo/dinto_DB00108 http://purl.obolibrary.org/obo/dinto_DB00552 http://purl.obolibrary.org/obo/CHEBI_44185 http://purl.obolibrary.org/obo/dinto_DB00928 http://purl.obolibrary.org/obo/CHEBI_681569 http://purl.obolibrary.org/obo/CHEBI_4027 http://purl.obolibrary.org/obo/dinto_DB00970 http://purl.obolibrary.org/obo/dinto_DB00005 http://purl.obolibrary.org/obo/CHEBI_4911 http://purl.obolibrary.org/obo/dinto_DB01206 http://purl.obolibrary.org/obo/dinto_DB00997 http://purl.obolibrary.org/obo/dinto_DB00054 http://purl.obolibrary.org/obo/CHEBI_4031 http://purl.obolibrary.org/obo/CHEBI_63612 http://purl.obolibrary.org/obo/CHEBI_61049 http://purl.obolibrary.org/obo/dinto_DB01380 http://purl.obolibrary.org/obo/dinto_DB00291 http://purl.obolibrary.org/obo/CHEBI_9513 http://purl.obolibrary.org/obo/CHEBI_3077 http://purl.obolibrary.org/obo/dinto_DB06287 http://purl.obolibrary.org/obo/CHEBI_63632 http://purl.obolibrary.org/obo/dinto_DB00081 http://purl.obolibrary.org/obo/CHEBI_8382 http://purl.obolibrary.org/obo/CHEBI_44423 http://purl.obolibrary.org/obo/CHEBI_17650 http://purl.obolibrary.org/obo/CHEBI_28680 http://purl.obolibrary.org/obo/dinto_DB01285 http://purl.obolibrary.org/obo/dinto_DB00570 http://purl.obolibrary.org/obo/CHEBI_31941 http://purl.obolibrary.org/obo/dinto_DB04572 http://purl.obolibrary.org/obo/CHEBI_63599 http://purl.obolibrary.org/obo/dinto_DB00290 http://purl.obolibrary.org/obo/CHEBI_9288 http://purl.obolibrary.org/obo/CHEBI_8764 http://purl.obolibrary.org/obo/dinto_DB01177 http://purl.obolibrary.org/obo/CHEBI_15367 http://purl.obolibrary.org/obo/dinto_DB00078 http://purl.obolibrary.org/obo/CHEBI_567361 http://purl.obolibrary.org/obo/CHEBI_75988 http://purl.obolibrary.org/obo/CHEBI_52172 http://purl.obolibrary.org/obo/dinto_DB00095 http://purl.obolibrary.org/obo/CHEBI_60761 http://purl.obolibrary.org/obo/dinto_DB00888 http://purl.obolibrary.org/obo/CHEBI_175901 http://purl.obolibrary.org/obo/dinto_DB00065 http://purl.obolibrary.org/obo/CHEBI_3423 http://purl.obolibrary.org/obo/dinto_DB00051 http://purl.obolibrary.org/obo/dinto_DB00004 http://purl.obolibrary.org/obo/CHEBI_50885 http://purl.obolibrary.org/obo/dinto_DB06372 http://purl.obolibrary.org/obo/CHEBI_480999 http://purl.obolibrary.org/obo/CHEBI_50924 http://purl.obolibrary.org/obo/CHEBI_6888 http://purl.obolibrary.org/obo/CHEBI_50729 http://purl.obolibrary.org/obo/dinto_DB00111 http://purl.obolibrary.org/obo/CHEBI_63791 http://purl.obolibrary.org/obo/dinto_DB00073 http://purl.obolibrary.org/obo/dinto_DB00026 http://purl.obolibrary.org/obo/CHEBI_47898 http://purl.obolibrary.org/obo/CHEBI_72564 http://purl.obolibrary.org/obo/CHEBI_9168 http://purl.obolibrary.org/obo/dinto_DB00023 http://purl.obolibrary.org/obo/dinto_DB00762 http://purl.obolibrary.org/obo/dinto_DB00488 http://purl.obolibrary.org/obo/dinto_DB00694 http://purl.obolibrary.org/obo/dinto_DB01281 http://purl.obolibrary.org/obo/CHEBI_50667 http://purl.obolibrary.org/obo/CHEBI_4868 http://purl.obolibrary.org/obo/CHEBI_8378 http://purl.obolibrary.org/obo/CHEBI_27899 http://purl.obolibrary.org/obo/dinto_DB00059 http://purl.obolibrary.org/obo/CHEBI_28876 http://purl.obolibrary.org/obo/dinto_DB00305 http://purl.obolibrary.org/obo/CHEBI_71418 http://purl.obolibrary.org/obo/CHEBI_114785 http://purl.obolibrary.org/obo/CHEBI_9555 http://purl.obolibrary.org/obo/CHEBI_46345 http://purl.obolibrary.org/obo/CHEBI_31355 http://purl.obolibrary.org/obo/dinto_DB00075 http://purl.obolibrary.org/obo/dinto_DB00074 http://purl.obolibrary.org/obo/CHEBI_38940 http://purl.obolibrary.org/obo/CHEBI_45783 http://purl.obolibrary.org/obo/CHEBI_168396 http://purl.obolibrary.org/obo/dinto_DB00087
prefixIRI	obo2:dinto_DB00072
prefLabel	trastuzumab
related with	http://purl.obolibrary.org/obo/dinto_3109 http://purl.obolibrary.org/obo/dinto_3105 http://purl.obolibrary.org/obo/dinto_3106 http://purl.obolibrary.org/obo/dinto_3107 http://purl.obolibrary.org/obo/dinto_3078 http://purl.obolibrary.org/obo/dinto_3084 http://purl.obolibrary.org/obo/dinto_2792 http://purl.obolibrary.org/obo/dinto_3112 http://purl.obolibrary.org/obo/dinto_3111 http://purl.obolibrary.org/obo/dinto_0259 http://purl.obolibrary.org/obo/dinto_3709 http://purl.obolibrary.org/obo/dinto_3461 http://purl.obolibrary.org/obo/dinto_3466
xref	GenBank:J00228 RxList:http://www.rxlist.com/cgi/generic/trastuz.htm National Drug Code Directory:50242-134-68 Drugs Product Database (DPD):2240692 PharmGKB:PA451743 Wikipedia:http://en.wikipedia.org/wiki/Trastuzumab UniProtKB:P01857 Drugs.com:http://www.drugs.com/cdi/trastuzumab.html
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.bioontology.org/ontology/NDFRT/N0000148593	NDFRT	LOOM
http://www.drugbank.ca/drugs/DB00072	FTC	LOOM
http://bmi.utah.edu/ontologies/hfontology/C0728747	HFO	LOOM
http://purl.bioontology.org/ontology/ATC/L01FD01	ATC	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#46592	OCHV	LOOM
http://purl.obolibrary.org/obo/NCIT_C1647	BERO	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148593	ODAE	LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000042265	PDQ	LOOM
http://purl.jp/bio/4/id/200906019489166096	IOBC	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C112748	RH-MESH	LOOM
http://purl.obolibrary.org/obo/OMIT_0001343	OMIT	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387003001	SNOMEDCT	LOOM
http://purl.bioontology.org/ontology/VANDF/4021140	VANDF	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1647	NCIT	LOOM
http://purl.bioontology.org/ontology/MESH/D000068878	MESH	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00022039	PMAPP-PMO	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0728747	OCHV	LOOM
http://purl.obolibrary.org/obo/MESH_D000068878	BERO	LOOM
http://purl.obolibrary.org/obo/DRON_00013025	PDRO	LOOM
http://purl.obolibrary.org/obo/DRON_00013025	DRON	LOOM
http://purl.obolibrary.org/obo/DRON_00013025	ODNAE	LOOM
https://go.drugbank.com/drugs/DB00072	MDM	LOOM
http://purl.bioontology.org/ontology/RXNORM/224905	RXNORM	LOOM