Preferred Name |
tenecteplase |
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Synonyms |
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|
ID |
http://purl.obolibrary.org/obo/dinto_DB00031 |
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AHFScode |
20:12.20 |
|
ATCCode |
B01AD11 |
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CASRN |
191588-94-0 |
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DBBrand |
tnkase (genentech inc) |
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DBSynonym |
t-plasminogen activator tissue-type plasminogen activator precursor t- pa tpa |
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Definition |
Tissue plasminogen activator (tPA). Tenecteplase is a 527 amino acid glycoprotein developed by introducing the following modifications to the complementary DNA (cDNA) for natural human tPA: a substitution of threonine 103 with asparagine, and a substitution of asparagine 117 with glutamine, both within the kringle 1 domain, and a tetra-alanine substitution at amino acids 296-299 in the protease domain. |
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has pharmacological target | ||
label |
tenecteplase |
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may interact with |
http://purl.obolibrary.org/obo/dinto_DB00055 http://purl.obolibrary.org/obo/dinto_DB01404 http://purl.obolibrary.org/obo/CHEBI_9588 |
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prefixIRI |
obo2:dinto_DB00031 |
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prefLabel |
tenecteplase |
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related with |
http://purl.obolibrary.org/obo/dinto_3086 http://purl.obolibrary.org/obo/dinto_3087 http://purl.obolibrary.org/obo/dinto_3059 http://purl.obolibrary.org/obo/dinto_3057 http://purl.obolibrary.org/obo/dinto_2603 http://purl.obolibrary.org/obo/dinto_1845 http://purl.obolibrary.org/obo/dinto_2148 http://purl.obolibrary.org/obo/dinto_0172 http://purl.obolibrary.org/obo/dinto_0504 |
|
xref |
Drugs.com:http://www.drugs.com/mtm/tenecteplase.html PharmGKB:PA164776757 National Drug Code Directory:50242-038-61 GenBank:L00153 Wikipedia:http://en.wikipedia.org/wiki/Tenecteplase RxList:http://www.rxlist.com/cgi/generic2/tenecteplase.htm Drugs Product Database (DPD):2244826 UniProtKB:P00750 |
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subClassOf |