loading...| Preferred Name |
microtubule-associated protein tau |
|
| Synonyms |
phf-tau paired helical filament-tau neurofibrillary tangle protein |
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| ID |
http://purl.obolibrary.org/obo/dinto_1696 |
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| binds | ||
| Definition |
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization |
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| definition source |
DrugBank Database |
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| Gene |
mapt |
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| is binded by | ||
| is pharmacological target of | ||
| label |
microtubule-associated protein tau |
|
| OrganismClass |
human |
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| prefixIRI |
obo2:dinto_1696 |
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| prefLabel |
microtubule-associated protein tau |
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| related with | ||
| Synonym |
phf-tau paired helical filament-tau neurofibrillary tangle protein |
|
| xref |
DrugBank:5923 UniProt ID:P10636 |
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| subClassOf |