loading...| Preferred Name |
glucokinase |
|
| Synonyms |
hk iv |
|
| ID |
http://purl.obolibrary.org/obo/dinto_1419 |
|
| Definition |
Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage |
|
| definition source |
DrugBank Database |
|
| Gene |
gck |
|
| label |
glucokinase |
|
| OrganismClass |
human |
|
| prefixIRI |
obo2:dinto_1419 |
|
| prefLabel |
glucokinase |
|
| related with |
http://purl.obolibrary.org/obo/dinto_DB07359 http://purl.obolibrary.org/obo/dinto_DB08210 http://purl.obolibrary.org/obo/dinto_DB08118 |
|
| Synonym |
hk iv hexokinase-d ec 2.7.1.2 hk4 hexokinase type iv hexokinase-4 |
|
| xref |
DrugBank:1675 UniProt ID:P35557 |
|
| subClassOf |