Preferred Name |
pasireotide |
|
Synonyms |
pasireotida pasireotide SOM 230 cyclo((4R)-4-(2-aminoethylcarbamoyloxy)-L-prolyl-L-phenylglycyl-D-tryptophyl-L-lysyl-4-O-benzyl-L-tyrosyl-L- phenylalanyl-) SOM230 C58H66N10O9 cyclo[(2S)-2-phenylglycyl-D-tryptophyl-L-lysyl-O-benzyl-L-tyrosyl-L-phenylalanyl-(4R)-4-{[(2-aminoethyl)carbamoyl]oxy}-L-prolyl] SOM-230 pasireotidum |
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ID |
http://purl.obolibrary.org/obo/CHEBI_72312 |
|
ATCCode |
H01CB05 |
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binds |
http://purl.obolibrary.org/obo/dinto_3391 http://purl.obolibrary.org/obo/dinto_0287 |
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CASRN |
396091-73-9 |
|
DBBrand |
signifor? |
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DBSalt |
pasireotide diaspartate |
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DBSynonym |
som230 |
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Definition |
A six-membered homodetic cyclic peptide composed from L-phenylglycyl, D-tryptophyl, L-lysyl, O-benzyl-L-tyrosyl, L-phenylalanyl and modified L-hydroxyproline residues joined in sequence. A somatostatin analogue with pharmacologic properties mimicking those of the natural hormone somatostatin; used (as its diaspartate salt) for treatment of Cushing's disease. Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor?, which is used in the treatment of Cushing s disease. |
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has role | ||
InChI |
InChI=1S/C58H66N10O9/c59-27-13-12-22-46-52(69)64-47(30-38-23-25-42(26-24-38)76-36-39-16-6-2-7-17-39)53(70)66-49(31-37-14-4-1-5-15-37)57(74)68-35-43(77-58(75)61-29-28-60)33-50(68)55(72)67-51(40-18-8-3-9-19-40)56(73)65-48(54(71)63-46)32-41-34-62-45-21-11-10-20-44(41)45/h1-11,14-21,23-26,34,43,46-51,62H,12-13,22,27-33,35-36,59-60H2,(H,61,75)(H,63,71)(H,64,69)(H,65,73)(H,66,70)(H,67,72)/t43-,46+,47+,48-,49+,50+,51+/m1/s1 |
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InChIKey |
InChIKey=VMZMNAABQBOLAK-DBILLSOUSA-N |
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label |
pasireotide |
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may interact with | ||
prefixIRI |
obo2:CHEBI_72312 |
|
prefLabel |
pasireotide |
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related with |
http://purl.obolibrary.org/obo/dinto_3391 http://purl.obolibrary.org/obo/dinto_0287 |
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SMILES |
NCCCC[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](NC(=O)[C@@H]2C[C@H](CN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(OCc3ccccc3)cc2)NC1=O)OC(=O)NCCN)c1ccccc1 |
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Synonym |
pasireotida pasireotide SOM 230 cyclo((4R)-4-(2-aminoethylcarbamoyloxy)-L-prolyl-L-phenylglycyl-D-tryptophyl-L-lysyl-4-O-benzyl-L-tyrosyl-L- phenylalanyl-) SOM230 C58H66N10O9 cyclo[(2S)-2-phenylglycyl-D-tryptophyl-L-lysyl-O-benzyl-L-tyrosyl-L-phenylalanyl-(4R)-4-{[(2-aminoethyl)carbamoyl]oxy}-L-prolyl] SOM-230 pasireotidum |
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xref |
KEGG DRUG:D10147 CiteXplore:22383336 CiteXplore:21493671 Wikipedia:http://en.wikipedia.org/wiki/Pasireotide CiteXplore:22634958 CiteXplore:21732759 CiteXplore:23137853 RxList:http://www.rxlist.com/signifor-drug.htm CiteXplore:22736724 CiteXplore:22807497 Wikipedia:Pasireotide CiteXplore:20643121 CiteXplore:22745760 CiteXplore:20970474 CiteXplore:22713526 CiteXplore:22965070 CiteXplore:21506098 CiteXplore:21330405 CiteXplore:21532334 CiteXplore:23345100 CiteXplore:21525729 CiteXplore:23102680 Reaxys:9469122 CiteXplore:21673137 CiteXplore:22282526 Drugs.com:http://www.drugs.com/signifor.html ChEBI:72312 CiteXplore:22170729 CiteXplore:22960304 CiteXplore:22573933 CiteXplore:21264796 CASRN:396091-73-9 |
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subClassOf |