loading...| Preferred Name |
perampanel |
|
| Synonyms |
Fycompa ER-155055-90 C23H15N3O perampanelum 3-(2-Cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one perampanel E 2007 2-(6'-oxo-1'-phenyl-1',6'-dihydro-2,3'-bipyridin-5'-yl)benzonitrile E2007 |
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| ID |
http://purl.obolibrary.org/obo/CHEBI_71013 |
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| ATCCode |
N03AX22 |
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| blocks | ||
| CASRN |
380917-97-5 |
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| DBBrand |
fycompa |
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| DBSynonym |
er-155055-90 e-2007 |
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| Definition |
A member of the class of bipyridines that is 2,3'-bipyridin-6'-one substituted at positions 1' and 5' by phenyl and 2-cyanophenyl groups respectively. Used as an adjunctive therapy for the treatment of partial-onset seizures in patients with epilepsy. Perampanel is a noncompetitive AMPA glutamate receptor antagonist. It is marketed under the name Fycompa? and is indicated as an adjunct in patients over 12 years old for the treatment of partial-onset seizures that may or may not occur with generalized seizures. The FDA label includes an important black-boxed warning of serious or life-threatening behavioral and psychiatric reactions in patients taking Fycompa?. |
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| has pharmacological target | ||
| has role | ||
| InChI |
InChI=1S/C23H15N3O/c24-15-17-8-4-5-11-20(17)21-14-18(22-12-6-7-13-25-22)16-26(23(21)27)19-9-2-1-3-10-19/h1-14,16H |
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| InChIKey |
InChIKey=PRMWGUBFXWROHD-UHFFFAOYSA-N |
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| induces | ||
| is metabolised by | ||
| label |
perampanel |
|
| may interact with |
http://purl.obolibrary.org/obo/dinto_DB01551 http://purl.obolibrary.org/obo/CHEBI_8107 http://purl.obolibrary.org/obo/CHEBI_2950 http://purl.obolibrary.org/obo/CHEBI_66910 |
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| prefixIRI |
obo2:CHEBI_71013 |
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| prefLabel |
perampanel |
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| SMILES |
O=c1c(cc(cn1-c1ccccc1)-c1ccccn1)-c1ccccc1C#N |
|
| Synonym |
Fycompa ER-155055-90 C23H15N3O perampanelum 3-(2-Cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one perampanel E 2007 2-(6'-oxo-1'-phenyl-1',6'-dihydro-2,3'-bipyridin-5'-yl)benzonitrile E2007 |
|
| xref |
CiteXplore:22222634 CASRN:380917-97-5 CiteXplore:22905878 Wikipedia:Perampanel CiteXplore:22776828 CiteXplore:22433907 CiteXplore:21686307 KEGG DRUG:D08964 CiteXplore:22650169 CiteXplore:21883097 CiteXplore:21635236 National Drug Code Directory:62856-282-30 Patent:US2009088574 RxList:http://www.rxlist.com/fycompa-drug.htm Patent:EP1875912 Wikipedia:http://en.wikipedia.org/wiki/Perampanel ChEBI:71013 CiteXplore:22913800 Patent:WO2006107859 CiteXplore:22788917 CiteXplore:22517103 Reaxys:11343244 Patent:US2008108603 CiteXplore:22161845 CiteXplore:22905857 ChEMBL:785974 CiteXplore:23093905 CiteXplore:23114872 Patent:WO2008111590 Drugs.com:http://www.drugs.com/mtm/perampanel.html CiteXplore:22843280 |
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| subClassOf |