loading...| Preferred Name |
ceftaroline fosamil |
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| Synonyms |
ceftarolina fosamilo 4-(2-{[(6R,7R)-2-carboxylato-7-[(2E)-2-(ethoxyimino)-2-[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]sulfanyl}-1,3-thiazol-4-yl)-1-methylpyridin-1-ium ceftaroline fosamil (6R,7R)-7-({(2Z)-2-(ethoxyimino)-2-[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]acetyl}amino)-3-{[4-(1-methylpyridinium-4-yl)-1,3-thiazol-2-yl]sulfanyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate C22H21N8O8PS4 ceftarolinum fosamilum |
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| ID |
http://purl.obolibrary.org/obo/CHEBI_70718 |
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| ATCCode |
J01DI02 |
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| DBBrand |
teflaro zinforo |
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| DBSynonym |
(6r,7r)-7-[(2z)-2-ethoxyimino-2-[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]acetyl]amino]-3-[4-(1-methylpyridin-1-ium-4-yl)-1,3-thiazol-2-yl]sulfanyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate ceftaroline tak-599 teflaro ppi 0903 |
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| Definition |
A cephalosporin that is the N-phospho prodrug of ceftaroline. A broad-spectrum antibiotic, it is active against methicillin-resistant Staphylococcus aureus (MRSA). It is used for the treatment of adults with acute bacterial skin and skin structure infections. Ceftaroline fosamil is a cephalosporin antibacterial indicated for the treatment of the following infections caused by designated susceptible bacteria: Acute bacterial skin and skin structure infections. Community-acquired bacterial pneumonia. |
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| has role |
http://purl.obolibrary.org/obo/CHEBI_22582 |
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| InChI |
InChI=1S/C22H21N8O8PS4/c1-3-38-26-13(16-25-21(43-28-16)27-39(35,36)37)17(31)24-14-18(32)30-15(20(33)34)12(9-40-19(14)30)42-22-23-11(8-41-22)10-4-6-29(2)7-5-10/h4-8,14,19H,3,9H2,1-2H3,(H4-,24,25,27,28,31,33,34,35,36,37)/b26-13+/t14-,19-/m1/s1 InChI=1S/C22H21N8O8PS4/c1-3-38-26-13(16-25-21(43-28-16)27-39(35,36)37)17(31)24-14-18(32)30-15(20(33)34)12(9-40-19(14)30)42-22-23-11(8-41-22)10-4-6-29(2)7-5-10/h4-8,14,19H,3,9H2,1-2H3,(H4-,24,25,27,28,31,33,34,35,36,37)/b26-13-/t14-,19-/m1/s1 |
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| InChIKey |
InChIKey=ZCCUWMICIWSJIX-XHNDKCDBSA-N InChIKey=ZCCUWMICIWSJIX-NQJJCJBVSA-N |
|
| label |
ceftaroline fosamil |
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| prefixIRI |
obo2:CHEBI_70718 |
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| prefLabel |
ceftaroline fosamil |
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| SMILES |
[H][C@]12SCC(Sc3nc(cs3)-c3cc[n+](C)cc3)=C(N1C(=O)[C@H]2NC(=O)C(=N/OCC)\\c1nsc(NP(O)(O)=O)n1)C([O-])=O [H][C@]12SCC(SC3=NC(=CS3)C3=CC=[N+](C)C=C3)=C(N1C(=O)[C@H]2NC(=O)C(=N\OCC)\C1=NSC(NP(O)(O)=O)=N1)C([O-])=O |
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| Synonym |
ceftarolina fosamilo 4-(2-{[(6R,7R)-2-carboxylato-7-[(2E)-2-(ethoxyimino)-2-[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]sulfanyl}-1,3-thiazol-4-yl)-1-methylpyridin-1-ium ceftaroline fosamil (6R,7R)-7-({(2Z)-2-(ethoxyimino)-2-[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]acetyl}amino)-3-{[4-(1-methylpyridinium-4-yl)-1,3-thiazol-2-yl]sulfanyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate C22H21N8O8PS4 ceftarolinum fosamilum |
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| xref |
CiteXplore:22314524 CiteXplore:21252841 CiteXplore:21897727 CiteXplore:21076711 CiteXplore:22985880 CiteXplore:22594846 CiteXplore:21482565 National Drug Code Directory:0456-0600-01 Patent:MX2012003411 ChEMBL:597230 CiteXplore:22354289 CiteXplore:22058102 CiteXplore:22355258 ChEBI:70718 Reaxys:9535806 Wikipedia:http://en.wikipedia.org/wiki/Ceftaroline_fosamil Wikipedia:Ceftaroline_fosamil CiteXplore:21162631 CiteXplore:21115453 CiteXplore:21393213 CiteXplore:21115454 CiteXplore:21482570 CiteXplore:21548186 Drugs.com:http://www.drugs.com/teflaro.html CiteXplore:22779432 CiteXplore:21482566 CiteXplore:21482568 PDRhealth:http://www.pdr.net/MedMerck-full-prescribing-information/teflaro?druglabeli CiteXplore:22330908 CASRN:229016-73-3 RxList:http://www.rxlist.com/teflaro-drug.htm CiteXplore:22903949 CiteXplore:21115456 CiteXplore:21115455 |
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| subClassOf |