The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

Details
Visualization
Notes ( 0 )
Class Mappings ( )

Preferred Name	memantine hydrochloride
Synonyms	3,5-dimethyltricyclo(3.3.1.1(3,7))decan-1-amine hydrochloride Memantine HCl memantine.HCl 3,5-dimethyladamantan-1-aminium chloride 3,5-dimethyladamantan-1-amine 1-Amino-3,5-dimethyladamantane hydrochloride 3,5-Dimethyl-1-adamantanamine hydrochloride C12H22ClN Namenda C12H21N 3,5-dimethyladamantan-1-amine hydrochloride
ID	http://purl.obolibrary.org/obo/CHEBI_64323
AHFScode	28:92.00
ATCCode	N06DX01
blocks	http://purl.obolibrary.org/obo/dinto_2810 http://purl.obolibrary.org/obo/dinto_2150 http://purl.obolibrary.org/obo/dinto_0750 http://purl.obolibrary.org/obo/dinto_3364 http://purl.obolibrary.org/obo/dinto_1123
CASRN	19982-08-2
DBBrand	ebixa namenda
DBname	memantine
DBSynonym	memantine [inn] memantine hcl memantinum [inn-latin] memantina [inn-spanish] memantine hydrochloride
Definition	A hydrochloride obtained by reaction of memantine with one equivalent of hydrochloric acid. A low to moderate affinity uncompetitive (open-channel); NMDA receptor antagonist which binds preferentially to the NMDA receptor-operated cation channels.
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0001297 http://purl.obolibrary.org/obo/OAE_0000496 http://purl.obolibrary.org/obo/OAE_0000395 http://purl.obolibrary.org/obo/OAE_0001373 http://purl.obolibrary.org/obo/OAE_0000597 http://purl.obolibrary.org/obo/OAE_0000604 http://purl.obolibrary.org/obo/OAE_0001505 http://purl.obolibrary.org/obo/OAE_0000838 http://purl.obolibrary.org/obo/OAE_0000905 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0001437 http://purl.obolibrary.org/obo/OAE_0001510 http://purl.obolibrary.org/obo/OAE_0000902 http://purl.obolibrary.org/obo/OAE_0001273 http://purl.obolibrary.org/obo/OAE_0000391 http://purl.obolibrary.org/obo/OAE_0000839 http://purl.obolibrary.org/obo/OAE_0000218 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000659 http://purl.obolibrary.org/obo/OAE_0000492 http://purl.obolibrary.org/obo/OAE_0001744 http://purl.obolibrary.org/obo/OAE_0000267 http://purl.obolibrary.org/obo/OAE_0000406 http://purl.obolibrary.org/obo/OAE_0000561 http://purl.obolibrary.org/obo/OAE_0000825 http://purl.obolibrary.org/obo/OAE_0001509 http://purl.obolibrary.org/obo/OAE_0000411 http://purl.obolibrary.org/obo/OAE_0000921 http://purl.obolibrary.org/obo/OAE_0001431 http://purl.obolibrary.org/obo/OAE_0000512 http://purl.obolibrary.org/obo/OAE_0001489 http://purl.obolibrary.org/obo/OAE_0000611 http://purl.obolibrary.org/obo/OAE_0001449 http://purl.obolibrary.org/obo/OAE_0000801 http://purl.obolibrary.org/obo/OAE_0000415 http://purl.obolibrary.org/obo/OAE_0000195 http://purl.obolibrary.org/obo/OAE_0000545 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000418 http://purl.obolibrary.org/obo/OAE_0001013 http://purl.obolibrary.org/obo/OAE_0000210 http://purl.obolibrary.org/obo/OAE_0000319 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0000317 http://purl.obolibrary.org/obo/OAE_0000482 http://purl.obolibrary.org/obo/OAE_0000197 http://purl.obolibrary.org/obo/OAE_0000382 http://purl.obolibrary.org/obo/OAE_0000250 http://purl.obolibrary.org/obo/OAE_0000365 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0000527 http://purl.obolibrary.org/obo/OAE_0001365 http://purl.obolibrary.org/obo/OAE_0000403 http://purl.obolibrary.org/obo/OAE_0000861 http://purl.obolibrary.org/obo/OAE_0000340 http://purl.obolibrary.org/obo/OAE_0001026 http://purl.obolibrary.org/obo/OAE_0000632 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0001463 http://purl.obolibrary.org/obo/OAE_0001433 http://purl.obolibrary.org/obo/OAE_0000300 http://purl.obolibrary.org/obo/OAE_0001340 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0000691 http://purl.obolibrary.org/obo/OAE_0001275 http://purl.obolibrary.org/obo/OAE_0000455 http://purl.obolibrary.org/obo/OAE_0001105 http://purl.obolibrary.org/obo/OAE_0000498 http://purl.obolibrary.org/obo/OAE_0000084 http://purl.obolibrary.org/obo/OAE_0000995 http://purl.obolibrary.org/obo/OAE_0001014 http://purl.obolibrary.org/obo/OAE_0001057 http://purl.obolibrary.org/obo/OAE_0000911 http://purl.obolibrary.org/obo/OAE_0000526 http://purl.obolibrary.org/obo/OAE_0001068 http://purl.obolibrary.org/obo/OAE_0001425 http://purl.obolibrary.org/obo/OAE_0000309 http://purl.obolibrary.org/obo/OAE_0001374 http://purl.obolibrary.org/obo/OAE_0000268 http://purl.obolibrary.org/obo/OAE_0000400 http://purl.obolibrary.org/obo/OAE_0000086 http://purl.obolibrary.org/obo/OAE_0000494 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0000842 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0000666 http://purl.obolibrary.org/obo/OAE_0000433 http://purl.obolibrary.org/obo/OAE_0000542 http://purl.obolibrary.org/obo/OAE_0000864 http://purl.obolibrary.org/obo/OAE_0000414 http://purl.obolibrary.org/obo/OAE_0000607 http://purl.obolibrary.org/obo/OAE_0001155 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000789 http://purl.obolibrary.org/obo/OAE_0000038 http://purl.obolibrary.org/obo/OAE_0001164 http://purl.obolibrary.org/obo/OAE_0000968 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0000166 http://purl.obolibrary.org/obo/OAE_0002122 http://purl.obolibrary.org/obo/OAE_0000460 http://purl.obolibrary.org/obo/OAE_0001403 http://purl.obolibrary.org/obo/OAE_0000647 http://purl.obolibrary.org/obo/OAE_0000306 http://purl.obolibrary.org/obo/OAE_0001336 http://purl.obolibrary.org/obo/OAE_0001356 http://purl.obolibrary.org/obo/OAE_0000022 http://purl.obolibrary.org/obo/OAE_0000385 http://purl.obolibrary.org/obo/OAE_0000185 http://purl.obolibrary.org/obo/OAE_0000491 http://purl.obolibrary.org/obo/OAE_0001305 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0000487 http://purl.obolibrary.org/obo/OAE_0000336 http://purl.obolibrary.org/obo/OAE_0000421 http://purl.obolibrary.org/obo/OAE_0001147 http://purl.obolibrary.org/obo/OAE_0000779 http://purl.obolibrary.org/obo/OAE_0001217 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000390 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000470 http://purl.obolibrary.org/obo/OAE_0000514 http://purl.obolibrary.org/obo/OAE_0001345 http://purl.obolibrary.org/obo/OAE_0000501 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0001166 http://purl.obolibrary.org/obo/OAE_0000881 http://purl.obolibrary.org/obo/OAE_0000211 http://purl.obolibrary.org/obo/OAE_0000462 http://purl.obolibrary.org/obo/OAE_0000358 http://purl.obolibrary.org/obo/OAE_0000716 http://purl.obolibrary.org/obo/OAE_0000618 http://purl.obolibrary.org/obo/OAE_0000534 http://purl.obolibrary.org/obo/OAE_0000885 http://purl.obolibrary.org/obo/OAE_0000480 http://purl.obolibrary.org/obo/OAE_0001364 http://purl.obolibrary.org/obo/OAE_0000402 http://purl.obolibrary.org/obo/OAE_0000304
has pharmacological target	http://purl.obolibrary.org/obo/dinto_2810 http://purl.obolibrary.org/obo/dinto_0750 http://purl.obolibrary.org/obo/dinto_3364
has role	http://purl.obolibrary.org/obo/CHEBI_48560 http://purl.obolibrary.org/obo/CHEBI_60797 http://purl.obolibrary.org/obo/CHEBI_63726 http://purl.obolibrary.org/obo/CHEBI_35469 http://purl.obolibrary.org/obo/CHEBI_48407
InChI	InChI=1S/C12H21N/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10/h9H,3-8,13H2,1-2H3 InChI=1S/C12H21N.ClH/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10;/h9H,3-8,13H2,1-2H3;1H
InChIKey	InChIKey=LDDHMLJTFXJGPI-UHFFFAOYSA-N InChIKey=BUGYDGFZZOZRHP-UHFFFAOYSA-N
inhibits	http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_2496 http://purl.obolibrary.org/obo/dinto_0465
is transported by	http://purl.obolibrary.org/obo/dinto_1979
label	memantine hydrochloride
prefixIRI	obo2:CHEBI_64323
prefLabel	memantine hydrochloride
SMILES	Cl.CC12CC3CC(C)(C1)CC(N)(C3)C2 CC12CC3CC(C)(C1)CC(N)(C3)C2
Synonym	3,5-dimethyltricyclo(3.3.1.1(3,7))decan-1-amine hydrochloride Memantine HCl memantine.HCl 3,5-dimethyladamantan-1-aminium chloride 3,5-dimethyladamantan-1-amine 1-Amino-3,5-dimethyladamantane hydrochloride 3,5-Dimethyl-1-adamantanamine hydrochloride C12H22ClN Namenda C12H21N 3,5-dimethyladamantan-1-amine hydrochloride
xref	CiteXplore:21792308 CiteXplore:20926740 CiteXplore:21220675 RxList:http://www.rxlist.com/cgi/generic3/namenda.htm Wikipedia:http://en.wikipedia.org/wiki/Memantine PDRhealth:http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/cx1682.shtml ChemSpider:3914 CiteXplore:21268245 KEGG DRUG:D04905 Patent:US2011282100 National Drug Code Directory:0456-3205-60 Patent:WO2011125062 Drugs.com:http://www.drugs.com/cdi/memantine.html CiteXplore:19196860 Reaxys:6573843 BindingDB:50062599 CASRN:41100-52-1 CiteXplore:20013176 CiteXplore:21213317 ChEMBL:645974 CiteXplore:21875407 PubChem Substance:46506702 Drugs Product Database (DPD):2260638 CiteXplore:21893967 PubChem Compound:4054 PharmGKB:PA10364 DrugBank:DB01043 CiteXplore:20703320 CiteXplore:22214393
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

Add comment

Add proposal

Subscribe to notes emails

Delete	Subject	Author	Type	Created
No notes to display

Create mapping

Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_64323	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_64323	BERO	SAME_URI
http://sbmi.uth.tmc.edu/ontology/ochv#C0771988	OCHV	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/426610008	SNOMEDCT	LOOM
http://purl.bioontology.org/ontology/RXNORM/236685	RXNORM	LOOM
http://purl.obolibrary.org/obo/NCIT_C47601	BERO	LOOM
http://doe-generated-ontology.com/OntoAD#C0771988	ONTOAD	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47601	NCIT	LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000579596	PDQ	LOOM
http://purl.obolibrary.org/obo/CHEBI_64323	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_64323	BERO	LOOM