COVID-19 Ontology

Last uploaded: February 25, 2021
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Preferred Name

tocilizumab
Synonyms
ID

http://purl.obolibrary.org/obo/DRON_00019607
fromPubMed

true
has_RxCUI

612865
imported from

http://purl.obolibrary.org/obo/dron.owl
label

tocilizumab
oboInOwl:hasDbXRef

https://www.ncbi.nlm.nih.gov/pubmed/32290839
oboInOwl:hasDefinition

A recombinant, humanized IgG1 monoclonal antibody directed against the interleukin-6 receptor (IL-6R) with immunosuppressant activity. Tocilizumab targets and binds to both the soluble form of IL-6R (sIL-6R) and the membrane-bound form (mIL-6R), thereby blocking the binding of IL-6 to its receptor. This prevents IL-6-mediated signaling. Il-6, a pro-inflammatory cytokine that plays an important role in the regulation of the immune response, is overproduced in autoimmune disorders, certain types of cancers and possibly various other inflammatory conditions.
prefixIRI

DRON:00019607
prefLabel

tocilizumab
subClassOf

http://purl.obolibrary.org/obo/CHEBI_23888
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http://purl.obolibrary.org/obo/DRON_00019607 PDRO SAME_URI
http://purl.obolibrary.org/obo/DRON_00019607 INBANCIDO SAME_URI
http://purl.obolibrary.org/obo/DRON_00019607 HOIP SAME_URI
http://purl.obolibrary.org/obo/DRON_00019607 DRON SAME_URI
http://purl.obolibrary.org/obo/DRON_00019607 CIDO SAME_URI
http://purl.obolibrary.org/obo/DRON_00019607 ODNAE SAME_URI
http://purl.obolibrary.org/obo/DRON_00019607 PDRO LOOM
http://purl.obolibrary.org/obo/DRON_00019607 INBANCIDO LOOM
http://purl.obolibrary.org/obo/DRON_00019607 HOIP LOOM
http://purl.obolibrary.org/obo/DRON_00019607 DRON LOOM
http://purl.obolibrary.org/obo/DRON_00019607 CIDO LOOM
http://purl.obolibrary.org/obo/DRON_00019607 ODNAE LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000180629 NDFRT LOOM
http://purl.bioontology.org/ontology/NDDF/013198 NDDF LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000713832 PDQ LOOM
https://github.com/sap218/ocimido/blob/master/ontology/ocimido.owl#OCIMIDO_00294 OCIMIDO LOOM
http://purl.bioontology.org/ontology/RXNORM/612865 RXNORM LOOM
http://purl.obolibrary.org/obo/CHEBI_64360 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_64360 BERO LOOM
http://purl.bioontology.org/ontology/ATC/L04AC07 ATC LOOM
http://www.phoc.org.cn/pmo/class/PMO_00026122 PMAPP-PMO LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000180629 INBANCIDO LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000180629 ODAE LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000180629 CIDO LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C84217 NCIT LOOM
https://github.com/sap218/coid/blob/master/coid.owl#COID_00481 COID LOOM
http://purl.bioontology.org/ontology/MESH/C502936 MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/444648007 SNOMEDCT LOOM
http://www.drugbank.ca/drugs/DB06273 FTC LOOM
https://go.drugbank.com/drugs/DB06273 MDM LOOM
http://purl.bioontology.org/ontology/LNC/MTHU065080 LOINC LOOM
http://purl.bioontology.org/ontology/VANDF/4029705 VANDF LOOM
http://purl.obolibrary.org/obo/dinto_DB06273 DINTO LOOM
http://bmi.utah.edu/ontologies/peontology/C1609165 RAO LOOM
http://purl.bioontology.org/ontology/LNC/LP420287-7 LOINC LOOM
http://purl.jp/bio/4/id/200906055820639940 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C502936 RH-MESH LOOM
http://purl.obolibrary.org/obo/NCIT_C84217 BERO LOOM