Preferred Name | ruxolitinib | |
Synonyms |
ruxolitinib INCB018424 (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile |
|
Definitions |
A pyrazole substituted at position 1 by a 2-cyano-1-cyclopentylethyl group and at position 3 by a pyrrolo[2,3-d]pyrimidin-4-yl group. Used as the phosphate salt for the treatment of patients with intermediate or high-risk myelofibrosis, including primary myelofibrosis, post-polycythemia vera myelofibrosis and post-essential thrombocythemia myelofibrosis. |
|
ID |
http://purl.obolibrary.org/obo/CHEBI_66919 |
|
alternative term |
ruxolitinib INCB018424 (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile |
|
charge |
0 |
|
chemical has protein target | ||
chemical inhibits protein | ||
database_cross_reference |
Patent:US2010190981 PMID:22399854 PMID:22227528 Drug_Central:4190 PMID:21919691 PMID:22422826 PMID:21926964 PMID:22279053 LINCS:LSM-1139 CAS:941678-49-5 PMID:22375970 PMID:22375971 PMID:22718840 PMID:22474318 Wikipedia:Ruxolitinib PMID:22034658 PMID:21602517 Reaxys:18703668 KEGG:D09959 PMID:22281165 PMID:22544377 Patent:US2008312258 PMID:22830345 |
|
definition source |
Reference: PMID: 22037378 |
|
formula |
C17H18N6 |
|
has exact synonym |
(3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile |
|
has role | ||
has_obo_namespace |
chebi_ontology |
|
has_related_synonym |
ruxolitinib INCB018424 |
|
has_role | ||
id |
CHEBI:66919 |
|
imported from | ||
in subset | ||
inchi |
InChI=1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m1/s1 |
|
inchikey |
HFNKQEVNSGCOJV-OAHLLOKOSA-N |
|
label |
ruxolitinib |
|
mass |
306.36500 |
|
monoisotopicmass |
306.15929 |
|
notation |
CHEBI:66919 |
|
prefLabel |
ruxolitinib |
|
smiles |
N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12 |
|
textual definition |
A pyrazole substituted at position 1 by a 2-cyano-1-cyclopentylethyl group and at position 3 by a pyrrolo[2,3-d]pyrimidin-4-yl group. Used as the phosphate salt for the treatment of patients with intermediate or high-risk myelofibrosis, including primary myelofibrosis, post-polycythemia vera myelofibrosis and post-essential thrombocythemia myelofibrosis. |
|
subClassOf |
http://purl.obolibrary.org/obo/CHEBI_18379 |
This ontology integrates with OntoloBridge, allowing community users to suggest additions to the public ontology. Complete the template below to submit a term request directly to the ontology maintainer.
Term Label (required)
Suggested term name. If a term can be described with multiple synonyms, only list the preferred name here.
Term description (required)
A brief definition, description, or usage of your suggested term. Additional term synonyms may be listed in this section.
Superclass (required)
The parent term of the suggested term. The parent term should be an existing entry of the current ontology. The superclass can be selected directly from Bioportal's Classes tree viewer.
References (optional)
Provide evidence for the existence of the requested term such as Pubmed IDs of papers or links to other resources that describe the term.
Justification (optional)
Provide any additional information about the requested term here.