Preferred Name

temozolomide

Synonyms

TMZ

MB 39831

8-carbamoyl-3-methylimidazo(5,1-d)-1,2,3,5-tetrazin-4(3H)-one

3,4-dihydro-3-methyl-4-oxoimidazo(5,1-d)-1,2,3,5-tetrazine-8-carboxamide

CCRG-81045

temozolomide

NSC 362856

M&B 39831

CCRIS 8996

Temodar

3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide

Sch 52365

3-methyl-4-oxo-3,4-dihydroimidazo(5,1-d)(1,2,3,5)tetrazine-8-carboxamide

M & B 39831

Temodal

methazolastone

3,4-dihydro-3-methyl-4-oxoimidazo(5,1-d)-as-tetrazine-8-carboxamide

temozolomida

CCRG 81045

BRN 5547136

temozolomidum

Definitions

An imidazotetrazine that is 3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine which is substituted at positions 3, 4, and 8 by methyl, oxo, and carboxamide groups, respectively. A prodrug for MTIC (5-(3-methyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide, formed by spontaneous hydrolysis of temozolomide in the body), it is used as an oral alkylating agent for the treatment of newly diagnosed malignant glioblastoma multiforme (concomitantly with radiotherapy) and malignant melanoma.

ID

http://purl.obolibrary.org/obo/CHEBI_72564

charge

0

database_cross_reference

KEGG:D06067

PMID:23389760

PMID:23377829

PMID:23335050

PMID:23254891

PMID:23246370

Reaxys:5547136

Wikipedia:Temozolomide

Drug_Central:2589

PMID:22680781

DrugBank:DB00853

PMID:23293540

LINCS:LSM-4590

CAS:85622-93-1

PMID:22818211

HMDB:HMDB0014991

PMID:23362460

Patent:DE3231255

PMID:23385995

definition

An imidazotetrazine that is 3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine which is substituted at positions 3, 4, and 8 by methyl, oxo, and carboxamide groups, respectively. A prodrug for MTIC (5-(3-methyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide, formed by spontaneous hydrolysis of temozolomide in the body), it is used as an oral alkylating agent for the treatment of newly diagnosed malignant glioblastoma multiforme (concomitantly with radiotherapy) and malignant melanoma.

formula

C6H6N6O2

has role

http://purl.obolibrary.org/obo/CHEBI_50266

http://purl.obolibrary.org/obo/CHEBI_35610

http://purl.obolibrary.org/obo/CHEBI_22333

has_exact_synonym

3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide

has_obo_namespace

chebi_ontology

has_related_synonym

TMZ

MB 39831

8-carbamoyl-3-methylimidazo(5,1-d)-1,2,3,5-tetrazin-4(3H)-one

3,4-dihydro-3-methyl-4-oxoimidazo(5,1-d)-1,2,3,5-tetrazine-8-carboxamide

CCRG-81045

temozolomide

NSC 362856

M&B 39831

CCRIS 8996

Temodar

Sch 52365

3-methyl-4-oxo-3,4-dihydroimidazo(5,1-d)(1,2,3,5)tetrazine-8-carboxamide

M & B 39831

Temodal

methazolastone

3,4-dihydro-3-methyl-4-oxoimidazo(5,1-d)-as-tetrazine-8-carboxamide

temozolomida

CCRG 81045

BRN 5547136

temozolomidum

id

CHEBI:72564

in_subset

http://purl.obolibrary.org/obo/chebi#3_STAR

inchi

InChI=1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13)

inchikey

BPEGJWRSRHCHSN-UHFFFAOYSA-N

label

temozolomide

mass

194.15080

monoisotopicmass

194.05522

notation

CHEBI:72564

prefLabel

temozolomide

smiles

Cn1nnc2c(ncn2c1=O)C(N)=O

treeView

http://purl.obolibrary.org/obo/CHEBI_72573

http://purl.obolibrary.org/obo/CHEBI_29347

http://purl.obolibrary.org/obo/CHEBI_72565

subClassOf

http://purl.obolibrary.org/obo/CHEBI_72573

http://purl.obolibrary.org/obo/CHEBI_29347

http://purl.obolibrary.org/obo/CHEBI_72565

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http://purl.bioontology.org/ontology/UATC/L01AX03 ATC LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000041671 PDQ LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#14908 OCHV LOOM
http://purl.bioontology.org/ontology/MESH/D000077204 MESH LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1244 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1244 NCIT LOOM
http://purl.obolibrary.org/obo/CHEBI_72564 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_72564 GO-PLUS SAME_URI
http://purl.obolibrary.org/obo/CHEBI_72564 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_72564 DINTO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_72564 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_72564 GO-PLUS SAME_URI
http://purl.bioontology.org/ontology/NDDF/007794 NDDF LOOM
http://purl.jp/bio/4/id/200906010256487782 IOBC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148622 NDFRT LOOM
http://purl.obolibrary.org/obo/DRON_00017608 DRON LOOM
http://purl.obolibrary.org/obo/DRON_00017608 DRON LOOM
http://www.ifomis.org/acgt/1.0#Temozolomide ACGT-MO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387009002 SNOMEDCT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0076080 OCHV LOOM
http://purl.bioontology.org/ontology/CSP/4008-0098 CRISP LOOM
http://purl.bioontology.org/ontology/RXNORM/37776 RXNORM LOOM
http://www.co-ode.org/ontologies/galen#Temozolomide GALEN LOOM
http://stirdf.jst.go.jp/id/200907074216809916 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C047246 RH-MESH LOOM
http://purl.bioontology.org/ontology/VANDF/4021173 VANDF LOOM