Preferred Name |
esmolol |
|
Synonyms |
rac-methyl 3-{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}propanoate ESMOLOL Esmolol methyl p-(2-hydroxy-3-(isopropylamino)propoxy)hydrocinnamate Methyl 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)benzenepropanoate esmololum esmolol (+-)-esmolol 3-[4-(2-Hydroxy-3-isopropylamino-propoxy)-phenyl]-propionic acid methyl ester (+-)-methyl p-(2-hydroxy-3-(isopropylamino)propoxy)hydrocinnamate |
|
Definitions |
A racemate comprising equimolar amounts of (R)- and (S)-esmolol. A cardioselective and short-acting beta1 receptor blocker with rapid onset but lacking intrinsic sympathomimetic and membrane-stabilising properties, it is used as the hydrochloride salt in the management of supraventricular arrhythmias, and for the control of hypertension and tachycardia during surgery. While the S enantiomer possesses all of the heart rate control, both enantiomers contribute to lowering blood pressure. |
|
ID |
http://purl.obolibrary.org/obo/CHEBI_4856 |
|
charge |
0 |
|
database_cross_reference |
PMID:25575405 PMID:25105423 PMID:26316443 Wikipedia:Esmolol PMID:16118074 Beilstein:5287174 CAS:103598-03-4 Patent:US4593119 PMID:26137757 HMDB:HMDB0014333 PMID:26073350 Patent:EP41491 PMID:24500140 CAS:81147-92-4 Patent:EP53435 DrugBank:DB00187 KEGG:D07916 KEGG:C06980 Reaxys:5287174 |
|
definition |
A racemate comprising equimolar amounts of (R)- and (S)-esmolol. A cardioselective and short-acting beta1 receptor blocker with rapid onset but lacking intrinsic sympathomimetic and membrane-stabilising properties, it is used as the hydrochloride salt in the management of supraventricular arrhythmias, and for the control of hypertension and tachycardia during surgery. While the S enantiomer possesses all of the heart rate control, both enantiomers contribute to lowering blood pressure. |
|
formula |
C16H25NO4 |
|
has functional parent | ||
has part | ||
has role | ||
has_alternative_id |
CHEBI:143354 |
|
has_exact_synonym |
rac-methyl 3-{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}propanoate ESMOLOL Esmolol |
|
has_obo_namespace |
chebi_ontology |
|
has_related_synonym |
methyl p-(2-hydroxy-3-(isopropylamino)propoxy)hydrocinnamate Methyl 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)benzenepropanoate esmololum esmolol (+-)-esmolol 3-[4-(2-Hydroxy-3-isopropylamino-propoxy)-phenyl]-propionic acid methyl ester (+-)-methyl p-(2-hydroxy-3-(isopropylamino)propoxy)hydrocinnamate |
|
id |
CHEBI:4856 |
|
in_subset | ||
label |
esmolol |
|
mass |
295.375 |
|
monoisotopicmass |
295.17836 |
|
notation |
CHEBI:4856 |
|
prefLabel |
esmolol |
|
treeView | ||
subClassOf |