loading...| Preferred Name |
artemether |
|
| Synonyms |
(3R,5aS,6R,8aS,9R,10S,12R,12aR)-10-methoxy-3,6,9-trimethyldecahydro-3,12-epoxypyrano[4,3-j][1,2]benzodioxepine beta-artemether (1R,4S,5R,8S,9R,10S,12R,13R)-10-methoxy-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.0^{4,13}.0^{8,13}]hexadecane artemisininelactol methyl ether artemether artemetero artemetherum 10-methoxy-1,5,9-trimethyl-(1R,4S,5R,8S,9R,10S,12R,13R)-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecane beta-dihydroartemisinin methyl ether dihydroartemisinin methyl ether methyl-dihydroartemisinine |
|
| Definitions |
An artemisinin derivative that is artemisinin in which the lactone has been converted to the corresponding lactol methyl ether. It is used in combination with lumefantrine as an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria. |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_195280 |
|
| charge |
0 |
|
| database_cross_reference |
PMID:3279208 CAS:71963-77-4 PMID:17404003 KEGG:D02483 PMID:18243702 Beilstein:6569878 PMID:12781185 LINCS:LSM-5519 PMID:11141088 PMID:17242150 DrugBank:DB06697 PMID:16033274 Wikipedia:Artemether Drug_Central:245 |
|
| definition |
An artemisinin derivative that is artemisinin in which the lactone has been converted to the corresponding lactol methyl ether. It is used in combination with lumefantrine as an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria. |
|
| formula |
C16H26O5 |
|
| has role | ||
| has_exact_synonym |
(3R,5aS,6R,8aS,9R,10S,12R,12aR)-10-methoxy-3,6,9-trimethyldecahydro-3,12-epoxypyrano[4,3-j][1,2]benzodioxepine |
|
| has_obo_namespace |
chebi_ontology |
|
| has_related_synonym |
beta-artemether (1R,4S,5R,8S,9R,10S,12R,13R)-10-methoxy-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.0^{4,13}.0^{8,13}]hexadecane artemisininelactol methyl ether artemether artemetero artemetherum 10-methoxy-1,5,9-trimethyl-(1R,4S,5R,8S,9R,10S,12R,13R)-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecane beta-dihydroartemisinin methyl ether dihydroartemisinin methyl ether methyl-dihydroartemisinine |
|
| id |
CHEBI:195280 |
|
| in_subset | ||
| inchi |
InChI=1S/C16H26O5/c1-9-5-6-12-10(2)13(17-4)18-14-16(12)11(9)7-8-15(3,19-14)20-21-16/h9-14H,5-8H2,1-4H3/t9-,10-,11+,12+,13+,14-,15-,16-/m1/s1 |
|
| inchikey |
SXYIRMFQILZOAM-HVNFFKDJSA-N |
|
| label |
artemether |
|
| mass |
298.37460 |
|
| monoisotopicmass |
298.17802 |
|
| notation |
CHEBI:195280 |
|
| prefLabel |
artemether |
|
| smiles |
[H][C@@]12CC[C@@]3(C)OO[C@@]11[C@@]([H])(CC[C@H]2C)[C@@H](C)[C@@H](OC)O[C@]1([H])O3 |
|
| treeView |
http://purl.obolibrary.org/obo/CHEBI_25702 http://purl.obolibrary.org/obo/CHEBI_59770 http://purl.obolibrary.org/obo/CHEBI_72588 |
|
| subClassOf |
http://purl.obolibrary.org/obo/CHEBI_25702 http://purl.obolibrary.org/obo/CHEBI_59770 http://purl.obolibrary.org/obo/CHEBI_72588 |