loading...| Preferred Name |
leuprolide acetate |
|
| Synonyms |
Enantone Lupron Pyr-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt.HOAc 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tryosyl-D-leucyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide monoacetate Lutrate Leuprorelin acetate 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide--acetic acid (1/1) |
|
| Definitions |
An acetate salt obtained by combining the nonapeptide leuprolide with acetic acid. A long lasting GnRH analog, LH-Rh agonist. It is a synthetic nonapeptide analogue of gonadotropin-releasing hormone, and is used as a subcutaneous hydrogel implant for the treatment of prostate cancer and for the suppression of gonadal sex hormone production in children with central precocious puberty. |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_63597 |
|
| charge |
0 |
|
| database_cross_reference |
PMID:22025196 PMID:21847353 DrugBank:DB00007 Wikipedia:Leuprorelin PMID:21790701 PMID:21239017 CAS:74381-53-6 PMID:21564386 PMID:22136615 Reaxys:5570787 PMID:21864378 PMID:22133574 PMID:21276459 PMID:22050405 PMID:21860633 PMID:21801354 KEGG:D00989 PMID:21324455 |
|
| definition |
An acetate salt obtained by combining the nonapeptide leuprolide with acetic acid. A long lasting GnRH analog, LH-Rh agonist. It is a synthetic nonapeptide analogue of gonadotropin-releasing hormone, and is used as a subcutaneous hydrogel implant for the treatment of prostate cancer and for the suppression of gonadal sex hormone production in children with central precocious puberty. |
|
| formula |
C61H88N16O14 |
|
| has part | ||
| has role | ||
| has_alternative_id |
CHEBI:6428 |
|
| has_exact_synonym |
5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-leucyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide--acetic acid (1/1) |
|
| has_obo_namespace |
chebi_ontology |
|
| has_related_synonym |
Enantone Lupron Pyr-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt.HOAc 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tryosyl-D-leucyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide monoacetate Lutrate Leuprorelin acetate |
|
| id |
CHEBI:63597 |
|
| in_subset | ||
| inchi |
InChI=1S/C59H84N16O12.C2H4O2/c1-6-63-57(86)48-14-10-22-75(48)58(87)41(13-9-21-64-59(60)61)68-51(80)42(23-32(2)3)69-52(81)43(24-33(4)5)70-53(82)44(25-34-15-17-37(77)18-16-34)71-56(85)47(30-76)74-54(83)45(26-35-28-65-39-12-8-7-11-38(35)39)72-55(84)46(27-36-29-62-31-66-36)73-50(79)40-19-20-49(78)67-40;1-2(3)4/h7-8,11-12,15-18,28-29,31-33,40-48,65,76-77H,6,9-10,13-14,19-27,30H2,1-5H3,(H,62,66)(H,63,86)(H,67,78)(H,68,80)(H,69,81)(H,70,82)(H,71,85)(H,72,84)(H,73,79)(H,74,83)(H4,60,61,64);1H3,(H,3,4)/t40-,41-,42-,43+,44-,45-,46-,47-,48-;/m0./s1 |
|
| inchikey |
RGLRXNKKBLIBQS-XNHQSDQCSA-N |
|
| label |
leuprolide acetate |
|
| mass |
1269.45020 |
|
| monoisotopicmass |
1268.66659 |
|
| notation |
CHEBI:63597 |
|
| prefLabel |
leuprolide acetate |
|
| smiles |
CC(O)=O.CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCC(=O)N1 |
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| treeView | ||
| subClassOf |