loading...| Preferred Name |
fludrocortisone acetate |
|
| Synonyms |
9-fluoro-11beta,17-dihydroxy-3,20-dioxopregn-4-en-21-yl acetate Cortineff 9alpha-fluorohydrocortisone acetate fluohydrocortisone acetate 9alpha-fluorohydrocortisone 21-acetate Alflorone F-Cortef Cortef-F (11beta)-9-fluoro-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl acetate Florinef acetate fludrocortisone 21-acetate U 4845 Florinef fluorocortisone acetate F-Cortef acetate Alflorone acetate Scherofluron |
|
| Definitions |
An acetate ester resulting from the formal condensation of the primary hydroxy group of fludrocortisone with acetic acid. A synthetic corticosteroid, it has glucocorticoid actions about 10 times as potent as hydrocortisone, while its mineralocorticoid actions are over 100 times as potent. It is used in partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison's disease and for the treatment of salt-losing adrenal hyperplasia. |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_5102 |
|
| charge |
0 |
|
| database_cross_reference |
PMID:24316163 PMID:13271122 KEGG:C08186 Patent:US2957013 Drug_Central:1191 KEGG:D00986 PMID:3197346 PMID:18193551 PMID:8248344 PMID:438959 CAS:514-36-3 PMID:8164382 PMID:13361498 Reaxys:3019450 |
|
| definition |
An acetate ester resulting from the formal condensation of the primary hydroxy group of fludrocortisone with acetic acid. A synthetic corticosteroid, it has glucocorticoid actions about 10 times as potent as hydrocortisone, while its mineralocorticoid actions are over 100 times as potent. It is used in partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison's disease and for the treatment of salt-losing adrenal hyperplasia. |
|
| formula |
C23H31FO6 |
|
| has functional parent | ||
| has_exact_synonym |
9-fluoro-11beta,17-dihydroxy-3,20-dioxopregn-4-en-21-yl acetate |
|
| has_obo_namespace |
chebi_ontology |
|
| has_related_synonym |
Cortineff 9alpha-fluorohydrocortisone acetate fluohydrocortisone acetate 9alpha-fluorohydrocortisone 21-acetate Alflorone F-Cortef Cortef-F (11beta)-9-fluoro-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl acetate Florinef acetate fludrocortisone 21-acetate U 4845 Florinef fluorocortisone acetate F-Cortef acetate Alflorone acetate Scherofluron |
|
| id |
CHEBI:5102 |
|
| in_subset | ||
| inchi |
InChI=1S/C23H31FO6/c1-13(25)30-12-19(28)22(29)9-7-16-17-5-4-14-10-15(26)6-8-20(14,2)23(17,24)18(27)11-21(16,22)3/h10,16-18,27,29H,4-9,11-12H2,1-3H3/t16-,17-,18-,20-,21-,22-,23-/m0/s1 |
|
| inchikey |
SYWHXTATXSMDSB-GSLJADNHSA-N |
|
| label |
fludrocortisone acetate |
|
| mass |
422.48700 |
|
| monoisotopicmass |
422.21047 |
|
| notation |
CHEBI:5102 |
|
| prefLabel |
fludrocortisone acetate |
|
| smiles |
CC(=O)OCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C |
|
| treeView |
http://purl.obolibrary.org/obo/CHEBI_47622 http://purl.obolibrary.org/obo/CHEBI_139592 http://purl.obolibrary.org/obo/CHEBI_36885 http://purl.obolibrary.org/obo/CHEBI_25354 http://purl.obolibrary.org/obo/CHEBI_50830 http://purl.obolibrary.org/obo/CHEBI_35342 |
|
| subClassOf |
http://purl.obolibrary.org/obo/CHEBI_47622 http://purl.obolibrary.org/obo/CHEBI_139592 http://purl.obolibrary.org/obo/CHEBI_36885 http://purl.obolibrary.org/obo/CHEBI_25354 http://purl.obolibrary.org/obo/CHEBI_50830 http://purl.obolibrary.org/obo/CHEBI_35342 |