loading...| Preferred Name |
edrophonium |
|
| Synonyms |
Edrophonium N-ethyl-3-hydroxy-N,N-dimethylanilinium edrophonium EDROPHONIUM N-ethyl-3-hydroxy-N,N-dimethylbenzenaminium Ethyl-(3-hydroxy-phenyl)-dimethyl-ammonium EDROPHONIUM ION (3-hydroxyphenyl)dimethylethylammonium 3-hydroxy-N,N-dimethyl-N-ethylanilinium |
|
| Definitions |
A quaternary ammonium ion that is N-ethyl-N,N-dimethylanilinium in which one of the meta positions is substituted by a hydroxy group. It is a reversible inhibitor of cholinesterase, with a rapid onset (30-60 seconds after injection) but a short duration of action (5-15 minutes). The chloride salt is used in myasthenia gravis both diagnostically and to distinguish between under- or over-treatment with other anticholinesterases. It has also been used for the reversal of neuromuscular blockade in anaesthesia, and for the management of poisoning due to tetrodotoxin, a neuromuscular blocking toxin found in puffer fish and other marine animals. |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_251408 |
|
| charge |
+1 |
|
| database_cross_reference |
LINCS:LSM-5867 CAS:312-48-1 PMID:7488499 PDBeChem:EDR Drug_Central:988 Beilstein:3905622 DrugBank:DB01010 KEGG:C06976 |
|
| definition |
A quaternary ammonium ion that is N-ethyl-N,N-dimethylanilinium in which one of the meta positions is substituted by a hydroxy group. It is a reversible inhibitor of cholinesterase, with a rapid onset (30-60 seconds after injection) but a short duration of action (5-15 minutes). The chloride salt is used in myasthenia gravis both diagnostically and to distinguish between under- or over-treatment with other anticholinesterases. It has also been used for the reversal of neuromuscular blockade in anaesthesia, and for the management of poisoning due to tetrodotoxin, a neuromuscular blocking toxin found in puffer fish and other marine animals. |
|
| formula |
C10H16NO |
|
| has role |
http://purl.obolibrary.org/obo/CHEBI_50247 |
|
| has_alternative_id |
CHEBI:42376 CHEBI:4758 |
|
| has_exact_synonym |
Edrophonium N-ethyl-3-hydroxy-N,N-dimethylanilinium edrophonium EDROPHONIUM |
|
| has_obo_namespace |
chebi_ontology |
|
| has_related_synonym |
N-ethyl-3-hydroxy-N,N-dimethylbenzenaminium Ethyl-(3-hydroxy-phenyl)-dimethyl-ammonium EDROPHONIUM ION (3-hydroxyphenyl)dimethylethylammonium 3-hydroxy-N,N-dimethyl-N-ethylanilinium |
|
| id |
CHEBI:251408 |
|
| in_subset | ||
| inchi |
InChI=1S/C10H15NO/c1-4-11(2,3)9-6-5-7-10(12)8-9/h5-8H,4H2,1-3H3/p+1 |
|
| inchikey |
VWLHWLSRQJQWRG-UHFFFAOYSA-O |
|
| label |
edrophonium |
|
| mass |
166.24010 |
|
| monoisotopicmass |
166.12264 |
|
| notation |
CHEBI:251408 |
|
| prefLabel |
edrophonium |
|
| smiles |
CC[N+](C)(C)c1cccc(O)c1 |
|
| treeView | ||
| subClassOf |